CUTANA™ CUT&Tag Kit
{"url":"https://www.epicypher.com/products/epigenetics-kits-and-reagents/cutana-cut-and-tag-kit","add_this":[{"service":"facebook","annotation":""},{"service":"email","annotation":""},{"service":"print","annotation":""},{"service":"twitter","annotation":""},{"service":"linkedin","annotation":""}],"gtin":null,"id":986,"bulk_discount_rates":[],"can_purchase":true,"meta_description":"CUTANA™ CUT&Tag Kit includes all needed reagents to go from cells to purified sequence-ready DNA. ","category":["Antibodies/CUTANA™ CUT&Tag Antibodies","Epigenetics Kits and Reagents/CUTANA™ CUT&Tag Assays"],"AddThisServiceButtonMeta":"","main_image":{"data":"https://cdn11.bigcommerce.com/s-y9o92/images/stencil/{:size}/products/986/1213/CTK20__46720.1713641110.png?c=2","alt":"CUTANA™ CUT&Tag Kit"},"add_to_wishlist_url":"/wishlist.php?action=add&product_id=986","shipping":{"calculated":true},"num_reviews":0,"weight":"0.01 LBS","custom_fields":[{"id":"1219","name":"Pack Size","value":"48 Reactions"}],"sku":"14-1102","description":"<div class=\"product-general-info\">\n <ul style=\"padding: 0\" class=\"product-general-info__list-right\">\n <li class=\"product-general-info__list-item\">\n <a href=\"#bioz\">\n <div id=\"w-s-3835-14-1102\" style=\"\n width: 240px;\n height: 58px;\n position: relative;\n overflow-y: hidden;\n \"></div>\n <!-- <div id=\"bioz-w-pb-14-1102-div\" style=\"width: 240px\">\n <a\n id=\"bioz-w-pb-14-1102\"\n style=\"font-size: 12px; color: transparent\"\n href=\"https://www.bioz.com/\"\n target=\"_blank\"\n >\n <img\n src=\"https://cdn.bioz.com/assets/favicon.png\"\n style=\"\n width: 11px;\n height: 11px;\n vertical-align: baseline;\n padding-bottom: 0px;\n margin-left: 0px;\n margin-bottom: 0px;\n float: none;\n display: none;\n \"\n />\n Powered by Bioz\n </a>\n </div> -->\n </a>\n </li>\n </ul>\n</div>\n<div class=\"service_accordion product-droppdown\">\n <div class=\"container\">\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel current\">\n <h3 class=\"sub-title1\">Description</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description-specific\">\n <p>\n The CUTANA™ CUT&Tag Kit offers a comprehensive solution for\n ultra-sensitive mapping of histone post-translational\n modifications (PTMs) [<a href=\"https://pubmed.ncbi.nlm.nih.gov/31036827/\">Kaya-Okur et al., 2019</a>]. This\n 48 reaction kit uses an exclusive Direct-to-PCR\n strategy to go from cells to PCR amplified sequencing\n libraries in one tube, bypassing traditional library prep and\n minimizing sample loss [<a href=\"https://pubmed.ncbi.nlm.nih.gov/32913232/\">Kaya-Okur et al., 2020</a>]. The\n protocol is also designed for compatibility with\n multi-channel pipetting for increased throughput and\n reproducibility. Positive (H3K27me3 and H3K4me3) and negative (IgG)\n control antibodies are paired with the SNAP-CUTANA™ K-MetStat\n Panel of nucleosome spike-in controls (<strong>Figure 2</strong>) to continuously monitor workflows and\n guide\n troubleshooting.\n </p>\n <p>\n The recommended input for CUT&Tag is 100,000 native nuclei per\n reaction. Comparable data can be generated down to 10,000\n nuclei, and the protocol is also validated for whole cells,\n cryopreserved samples, and lightly cross-linked nuclei or\n cells. CUT&Tag provides robust profiling for histone PTMs. For\n chromatin-associated proteins (e.g. transcription factors),\n CUTANA™ CUT&RUN is recommended (EpiCypher\n <a href=\"/products/epigenetics-reagents-and-assays/cutana-chic-cut-and-run-kit\">14-1048</a>, EpiCypher\n <a\n href=\"/products/epigenetics-reagents-and-assays/cutana-cut-and-run-library-prep-kit\">14-1001/14-1002</a>).\n </p>\n </div>\n </div>\n </div>\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel current\">\n <h3 class=\"sub-title1\">Validation Data</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description-specific\">\n <section class=\"image-picker\">\n <div class=\"image-picker__left\">\n <div class=\"image-picker__main-content_active image-picker__main-content\">\n <div class=\"image-picker__header-content\">\n <button class=\"image-picker__left-arrow\">\n <svg class=\"image-picker__svg-left\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M16.67 0l2.83 2.829-9.339 9.175 9.339 9.167-2.83 2.829-12.17-11.996z\" />\n </svg>\n </button>\n <a href=\"/content/images/products/kits/14-1102-distribution-analysis.jpeg\" target=\"_new\"\n class=\"image-picker__main-image-link\"><img alt=\"14-1102-distribution-analysis\"\n src=\"/content/images/products/kits/14-1102-distribution-analysis.jpeg\"\n class=\"image-picker__main-image\" />\n <span class=\"image-picker__main-image-caption\">(Click to enlarge)</span></a>\n <button class=\"image-picker__right-arrow\">\n <svg class=\"image-picker__svg-right\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M7.33 24l-2.83-2.829 9.339-9.175-9.339-9.167 2.83-2.829 12.17 11.996z\" />\n </svg>\n </button>\n </div>\n <p>\n <span class=\"image-picker__span-content\"><strong>Figure 1: CUT&Tag DNA fragment size distribution\n analysis</strong><br />\n CUT&Tag was performed as described in\n <strong>Figure 5</strong>. Library DNA was analyzed by\n Agilent TapeStation<sup>®</sup>, which confirmed that\n mononucleosomes were predominantly enriched in CUT&Tag\n (peak between 300-400 bp). Peak between 500-700 bp\n represents dinucleosomes.\n </span>\n </p>\n </div>\n <div class=\"image-picker__main-content\">\n <div class=\"image-picker__header-content\">\n <button class=\"image-picker__left-arrow\">\n <svg class=\"image-picker__svg-left\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M16.67 0l2.83 2.829-9.339 9.175 9.339 9.167-2.83 2.829-12.17-11.996z\" />\n </svg>\n </button>\n <a href=\"/content/images/products/kits/14-1102-spike-in-controls.jpeg\" target=\"_new\"\n class=\"image-picker__main-image-link\"><img alt=\"14-1102-spike-in-controls\"\n src=\"/content/images/products/kits/14-1102-spike-in-controls.jpeg\"\n class=\"image-picker__main-image\" />\n <span class=\"image-picker__main-image-caption\">(Click to enlarge)</span></a>\n <button class=\"image-picker__right-arrow\">\n <svg class=\"image-picker__svg-right\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M7.33 24l-2.83-2.829 9.339-9.175-9.339-9.167 2.83-2.829 12.17 11.996z\" />\n </svg>\n </button>\n </div>\n <p>\n <span class=\"image-picker__span-content\"><strong>Figure 2: SNAP-CUTANA™ K-MetStat Spike-in\n controls</strong><br />\n DNA-barcoded designer nucleosomes (dNucs) representing 16 different K-methyl PTM states: mono-, di-,\n and tri-methylation at H3K4, H3K9, H3K27, H3K36, and H4K20, as well as unmodified control, were\n spiked into CUT&Tag samples prior to the addition of the control antibodies provided with the kit\n (IgG, H3K27me3, H3K4me3). After sequencing, instances of each spike-in barcode recovered in the\n CUT&Tag reactions were counted and normalized from raw fastq files using the shell script and\n analysis Excel sheet available on the spike-in product page (EpiCypher <a\n href=\"/products/nucleosomes/snap-cutana-k-metstat-panel\" target=\"_blank\">19-1002</a>). Barcodes\n for IgG\n (top; normalized to the sum of total reads), H3K27me3 (middle; normalized to on-target), and H3K4me3\n (bottom; normalized to on-target) antibodies provided with this kit are shown. The spike-ins\n confirmed optimal experimental conditions (H3K27me3 and H3K4me3 antibodies specifically recovered\n the target dNuc, while IgG showed no preferential enrichment).\n </span>\n </p>\n </div>\n <div class=\"image-picker__main-content\">\n <div class=\"image-picker__header-content\">\n <button class=\"image-picker__left-arrow\">\n <svg class=\"image-picker__svg-left\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M16.67 0l2.83 2.829-9.339 9.175 9.339 9.167-2.83 2.829-12.17-11.996z\" />\n </svg>\n </button>\n <a href=\"/content/images/products/kits/14-1102-genome-wide-heatmaps.jpeg\" target=\"_new\"\n class=\"image-picker__main-image-link\">\n <img alt=\"14-1102-genome-wide-heatmaps\"\n src=\"/content/images/products/kits/14-1102-genome-wide-heatmaps.jpeg\"\n class=\"image-picker__main-image\" />\n <span class=\"image-picker__main-image-caption\">(Click to enlarge)</span>\n </a>\n <button class=\"image-picker__right-arrow\">\n <svg class=\"image-picker__svg-right\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M7.33 24l-2.83-2.829 9.339-9.175-9.339-9.167 2.83-2.829 12.17 11.996z\" />\n </svg>\n </button>\n </div>\n <p>\n <span class=\"image-picker__span-content\">\n <strong>Figure 3: CUT&Tag genome-wide heatmaps</strong><br />\n CUT&Tag was performed as described in <strong>Figure 5</strong>. Heatmaps show two replicates\n (“Rep”) of IgG and\n H3K4me3 antibodies in aligned rows ranked by intensity (top to bottom) relative to the H3K4me3 Rep 1\n reaction. High, medium, and low intensity are shown in red, yellow, and blue, respectively.\n Antibodies to histone PTMs showed expected enrichment patterns and high reproducibility. H3K4me3, a\n marker of active transcription localized to transcription start sites (TSSs), shows enrichment\n consistent at TSSs, as expected. IgG shows low background enrichment.\n </span>\n </p>\n </div>\n <div class=\"image-picker__main-content\">\n <div class=\"image-picker__header-content\">\n <button class=\"image-picker__left-arrow\">\n <svg class=\"image-picker__svg-left\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M16.67 0l2.83 2.829-9.339 9.175 9.339 9.167-2.83 2.829-12.17-11.996z\" />\n </svg>\n </button>\n <a href=\"/content/images/products/kits/14-1102-gene-browser-tracks.jpeg\" target=\"_new\"\n class=\"image-picker__main-image-link\">\n <img alt=\"14-1102-gene-browser-tracks\"\n src=\"/content/images/products/kits/14-1102-gene-browser-tracks.jpeg\"\n class=\"image-picker__main-image\" />\n <span class=\"image-picker__main-image-caption\">(Click to enlarge)</span>\n </a>\n <button class=\"image-picker__right-arrow\">\n <svg class=\"image-picker__svg-right\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M7.33 24l-2.83-2.829 9.339-9.175-9.339-9.167 2.83-2.829 12.17 11.996z\" />\n </svg>\n </button>\n </div>\n <p>\n <span class=\"image-picker__span-content\">\n <strong>Figure 4: Representative gene browser\n tracks</strong><br />\n CUT&Tag was performed as described in <strong>Figure 5</strong>. A representative 186 kb window at\n the LAMC3 gene is\n shown for two replicates (“Rep”) of IgG, H3K27me3, and H3K4me3 kit control antibodies.\n Representative tracks are also shown for two replicates of H3K4me1 antibody. The CUT&Tag kit\n produced the expected genomic distribution for each target. Images were generated using the\n Integrative Genomics Viewer (IGV, Broad Institute).\n </span>\n </p>\n </div>\n <div class=\"image-picker__main-content\">\n <div class=\"image-picker__header-content\">\n <button class=\"image-picker__left-arrow\">\n <svg class=\"image-picker__svg-left\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M16.67 0l2.83 2.829-9.339 9.175 9.339 9.167-2.83 2.829-12.17-11.996z\" />\n </svg>\n </button>\n <a href=\"/content/images/products/methods/cut-and-tag-methods.png\" target=\"_new\"\n class=\"image-picker__main-image-link\">\n <img alt=\"cut-and-tag-methods\" src=\"/content/images/products/methods/cut-and-tag-methods.png\"\n class=\"image-picker__main-image\" />\n <span class=\"image-picker__main-image-caption\">(Click to enlarge)</span>\n </a>\n <button class=\"image-picker__right-arrow\">\n <svg class=\"image-picker__svg-right\" width=\"24\" height=\"24\" viewBox=\"0 0 24 24\">\n <path d=\"M7.33 24l-2.83-2.829 9.339-9.175-9.339-9.167 2.83-2.829 12.17 11.996z\" />\n </svg>\n </button>\n </div>\n <p>\n <span class=\"image-picker__span-content\">\n <strong>Figure 5: CUT&Tag methods </strong><br />\n CUT&Tag was performed using the CUTANA™ CUT&Tag Kit starting with 100k K562 cells and 0.5 µg of\n either IgG (EpiCypher <a\n href=\"/products/nucleosomes/snap-cutana-spike-in-controls/cutana-igg-negative-control-antibody-for-cut-run-and-cut-tag\"\n target=\"_blank\">13-0042</a>t), H3K27me3 (EpiCypher <a\n href=\"/products/antibodies/h3k27me3-antibody-snap-certified-for-cut-run-and-cut-and-tag\"\n target=\"_blank\">13-0055</a>t), H3K4me3 (EpiCypher <a\n href=\"/products/antibodies/h3k4me3-antibody-snap-certified-for-cut-run-and-cut-tag\"\n target=\"_blank\">13-0060</a>t), or\n H3K4me1 (EpiCypher <a\n href=\"/products/antibodies/cut-and-run-antibodies/cut-and-run-antibodies-histone-ptms/h3k4me1-antibody-snap-certified-for-cut-and-run-and-cut-and-tag\"\n target=\"_blank\">13-0057</a>) antibodies. Libraries were run on an Illumina NextSeq2000 with\n paired-end sequencing (2x50 bp). Sample sequencing depth was 5.3/4.1 million reads (IgG Rep 1/Rep\n 2), 11.2/9.0 million reads (H3K27me3 Rep 1/Rep 2), 8.6/5.0 million reads (H3K4me3 Rep 1/Rep 2), and\n 4.1/10.3 million reads (H3K4me1 Rep 1/Rep 2). Data were aligned to the hg19 genome using Bowtie2.\n Data were filtered to remove duplicates, multi-aligned reads, and ENCODE DAC Exclusion List regions.\n </span>\n </p>\n </div>\n </div>\n <aside class=\"image-picker__right\">\n <div class=\"image-picker__gallery\">\n <img alt=\"14-1102-distribution-analysis\"\n src=\"/content/images/products/kits/14-1102-distribution-analysis.jpeg\" width=\"200\"\n class=\"image-picker__side-image image-picker__side-image_active\" role=\"button\" />\n <img alt=\"14-1102-spike-in-controls\" src=\"/content/images/products/kits/14-1102-spike-in-controls.jpeg\"\n class=\"image-picker__side-image\" role=\"button\" />\n <img alt=\"14-1102-genome-wide-heatmaps\"\n src=\"/content/images/products/kits/14-1102-genome-wide-heatmaps.jpeg\" class=\"image-picker__side-image\"\n role=\"button\" />\n <img alt=\"14-1102-gene-browser-tracks\"\n src=\"/content/images/products/kits/14-1102-gene-browser-tracks.jpeg\" class=\"image-picker__side-image\"\n role=\"button\" />\n <img alt=\"cut-and-tag-methods\" src=\"/content/images/products/methods/cut-and-tag-methods.png\"\n class=\"image-picker__side-image\" role=\"button\" />\n </div>\n </aside>\n </section>\n </div>\n </div>\n </div>\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel\">\n <h3 class=\"sub-title1\">Kit Contents</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description\">\n <table class=\"epicypher-table\">\n <tr>\n <th>Item</th>\n <th>Cat. No.</th>\n </tr>\n\n <tr>\n <td>CUTANA™ pAG-Tn5 for CUT&Tag</td>\n <td>\n <a href=\"/products/epigenetics-kits-and-reagents/cutana-pag-tn5-for-cut-and-tag\">15-1017</a>t\n </td>\n </tr>\n\n <tr>\n <td>\n H3K27me3 Antibody, SNAP-Certified™ for CUT&RUN and CUT&Tag\n </td>\n <td>\n <a href=\"/products/antibodies/h3k27me3-antibody-snap-certified-for-cut-run-and-cut-and-tag\">13-0055</a>t\n </td>\n </tr>\n\n <tr>\n <td>\n H3K4me3 Antibody, SNAP-Certified™ for CUT&RUN and CUT&Tag\n </td>\n <td>\n <a href=\"/products/antibodies/h3k4me3-antibody-snap-certified-for-cut-run-and-cut-tag\">13-0060</a>t\n </td>\n </tr>\n\n <tr>\n <td>\n CUTANA™ Rabbit IgG CUT&RUN Negative Control Antibody\n </td>\n <td>\n <a\n href=\"/products/nucleosomes/snap-cutana-spike-in-controls/cutana-rabbit-igg-cut-run-negative-control-antibody\">13-0042</a>t\n </td>\n </tr>\n\n <tr>\n <td>\n Anti-Rabbit Secondary Antibody for CUTANA™ CUT&Tag\n Workflows\n </td>\n <td>\n <a\n href=\"/products/antibodies/cutana-cut-tag-antibodies/anti-rabbit-secondary-antibody-for-cutana-cut-tag-workflows\">13-0047</a>t\n </td>\n </tr>\n\n <tr>\n <td>SNAP-CUTANA™ K-MetStat Panel</td>\n <td>\n <a href=\"/products/nucleosomes/snap-cutana-k-metstat-panel\">19-1002</a>t\n </td>\n </tr>\n\n <tr>\n <td>\n CUTANA™ Concanavalin A Conjugated Paramagnetic Beads\n </td>\n <td>\n <a\n href=\"/products/epigenetics-kits-and-reagents/cutana-chic-cut-run-assays/cutana-concanavalin-a-conjugated-paramagnetic-beads\">21-1401</a>t\n </td>\n </tr>\n\n <tr>\n <td>CUTANA™ Non-Hot Start 2X PCR Master Mix for CUT&Tag</td>\n <td>\n <a\n href=\"/products/epigenetics-kits-and-reagents/cutana-cut-tag-assays/cutana-non-hot-start-2x-pcr-master-mix-for-cut-tag\">15-1018</a>t\n </td>\n </tr>\n\n <tr>\n <td>CUTANA™ CUT&RUN 8-strip 0.2 mL Tubes</td>\n <td>\n <a\n href=\"/products/epigenetics-kits-and-reagents/cutana-chic-cut-run-assays/cutana-cut-run-8-strip-0-2-ml-tubes\">10-0009</a>t\n </td>\n </tr>\n\n <tr>\n <td>4.5 M NaCl</td>\n <td>21-1013t</td>\n </tr>\n\n <tr>\n <td>0.5 M EDTA</td>\n <td>21-1006t</td>\n </tr>\n\n <tr>\n <td>1 M MgCl<sub>2</sub></td>\n <td>21-1015t</td>\n </tr>\n\n <tr>\n <td>SDS Release Buffer</td>\n <td>21-1017t</td>\n </tr>\n\n <tr>\n <td>SDS Quench Buffer</td>\n <td>21-1018t</td>\n </tr>\n\n <tr>\n <td>0.1X TE Buffer</td>\n <td>21-1025t</td>\n </tr>\n\n <tr>\n <td>Pre-Wash Buffer</td>\n <td>21-1002t</td>\n </tr>\n\n <tr>\n <td>Pre-Nuclear Extraction Buffer</td>\n <td>21-1021t</td>\n </tr>\n\n <tr>\n <td>Bead Activation Buffer</td>\n <td>21-1001t</td>\n </tr>\n\n <tr>\n <td>5% Digitonin</td>\n <td>21-1004t</td>\n </tr>\n\n <tr>\n <td>1 M Spermidine</td>\n <td>21-1005t</td>\n </tr>\n\n <tr>\n <td>\n SPRIselect reagent manufactured by Beckman Coulter, Inc\n </td>\n <td>21-1405t</td>\n </tr>\n\n <tr>\n <td style=\"vertical-align: top\">Multiplexing Primers</td>\n <td>\n 14-1102 and 14-1103 each contain combinatorial dual\n indices for multiplexed sequencing of up to 48 reactions.\n Combine the kits to multiplex up to 96 reactions.\n </td>\n </tr>\n </table>\n </div>\n </div>\n </div>\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel\">\n <h3 class=\"sub-title1\">Recommended Accessory Products</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description\">\n <table class=\"epicypher-table\">\n <tr>\n <th>Item</th>\n <th>Cat. No.</th>\n </tr>\n\n <tr>\n <td id=\"specific-row\">\n Anti-Mouse Secondary Antibody for CUTANA™ CUT&Tag\n Workflows\n </td>\n <td>\n <a\n href=\"/products/epigenetics-reagents-and-assays/cutanac-cut-tag-assays/anti-mouse-secondary-antibody-for-cutana-cut-tag-workflows\">13-0048</a>\n </td>\n </tr>\n\n <tr>\n <td>SNAP-CUTANA™ K-MetStat Panel</td>\n <td>\n <a href=\"/products/nucleosomes/snap-cutana-k-metstat-panel\">19-1002</a>\n </td>\n </tr>\n\n <tr>\n <td id=\"specific-row\">CUT&Tag Antibodies</td>\n <td>\n <a href=\"/products/antibodies/cutana-cut-and-tag-antibodies\">See the list</a>\n </td>\n </tr>\n\n <tr>\n <td id=\"specific-row\">\n Magnetic Separation Rack, 0.2 mL Tubes\n </td>\n <td>\n <a\n href=\"/products/epigenetics-reagents-and-assays/cutana-chic-cut-run-assays/magnetic-separation-rack-0-2-ml-tubes\">10-0008</a>\n </td>\n </tr>\n\n <tr>\n <td id=\"specific-row\">\n Magnetic Separation Rack, 1.5 mL Tubes\n </td>\n <td>\n <a href=\"/products/epigenetics-reagents-and-assays/magnetic-separation-rack-1-5-ml-tubes\">10-0012</a>\n </td>\n </tr>\n </table>\n </div>\n </div>\n </div>\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel\">\n <h3 class=\"sub-title1\">Technical Information</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description\">\n <div class=\"product-tech-info\">\n <div class=\"product-tech-info__line-item\">\n <div class=\"product-tech-info__line-item-left\">\n <b>Storage</b>\n </div>\n <div class=\"product-tech-info__line-item-right\">\n OPEN KIT IMMEDIATELY and store components at room\n temperature, 4°C, and -20°C as indicated (see Kit Manual).\n Stable for 6 months upon date of receipt.\n </div>\n </div>\n <div class=\"product-tech-info__line-item\">\n <div class=\"product-tech-info__line-item-left\">\n <b>Instructions for Use</b>\n </div>\n <div class=\"product-tech-info__line-item-right\">\n See Kit Manual\n </div>\n </div>\n </div>\n </div>\n </div>\n </div>\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel\">\n <h3 class=\"sub-title1\">Additional Information</h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description\">\n <p>\n Beckman Coulter, the stylized logo, and SPRIselect are\n trademarks or registered trademarks of Beckman Coulter, Inc.\n in the United States and other countries.\n </p>\n </div>\n </div>\n </div>\n\n <h3 style=\"color: #4698cb; font-size: 24px; border-bottom: none;\" class=\"custom-title-description\">\n Documents & Resources\n </h3>\n\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel\">\n <!-- <h3 style=\"color: #4698cb; margin-bottom: 0\">Current Lot</h3> -->\n <h3 style=\"padding-bottom: 5px; margin-top: 1rem; padding-top: 0\" class=\"sub-title1\">\n Kit Version 3\n </h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description\">\n <div class=\"product-documents\">\n <a href=\"/content/documents/tds/14-1102.pdf\" target=\"_new\" class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0002 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n d=\"M191.92,68.77l-47.69-47.69c-1.33-1.33-3.12-2.08-5.01-2.08H45.09C41.17,19,38,22.17,38,26.09v184.36\n c0,3.92,3.17,7.09,7.09,7.09h141.82c3.92,0,7.09-3.17,7.09-7.09V73.8C194,71.92,193.25,70.1,191.92,68.77z M177.65,77.06h-41.7\n v-41.7L177.65,77.06z M178.05,201.59H53.95V34.95h66.92v47.86c0,5.14,4.17,9.31,9.31,9.31h47.86V201.59z\" />\n </g>\n <rect x=\"20\" y=\"112\" class=\"product-documents__svg-background\" width=\"146\" height=\"76\" />\n <g>\n <path class=\"product-documents__svg-pdf\" d=\"M23.83,125.68h22.36c5.29,0,9.41,1.33,12.35,4c2.94,2.67,4.42,6.39,4.42,11.18c0,4.78-1.47,8.51-4.42,11.18\n c-2.94,2.67-7.06,4-12.35,4H34.59v18.29H23.83V125.68z M44.81,147.9c5.38,0,8.07-2.32,8.07-6.97c0-2.39-0.67-4.16-2-5.31\n c-1.33-1.15-3.36-1.73-6.07-1.73H34.59v14.01H44.81z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M69.92,125.68h18.91c5.29,0,9.84,0.97,13.66,2.9c3.82,1.93,6.74,4.72,8.76,8.35\n c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">Technical Datasheet (14-1102)</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/tds/14-1103.pdf\" target=\"_new\" class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0002 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n d=\"M191.92,68.77l-47.69-47.69c-1.33-1.33-3.12-2.08-5.01-2.08H45.09C41.17,19,38,22.17,38,26.09v184.36\n c0,3.92,3.17,7.09,7.09,7.09h141.82c3.92,0,7.09-3.17,7.09-7.09V73.8C194,71.92,193.25,70.1,191.92,68.77z M177.65,77.06h-41.7\n v-41.7L177.65,77.06z M178.05,201.59H53.95V34.95h66.92v47.86c0,5.14,4.17,9.31,9.31,9.31h47.86V201.59z\" />\n </g>\n <rect x=\"20\" y=\"112\" class=\"product-documents__svg-background\" width=\"146\" height=\"76\" />\n <g>\n <path class=\"product-documents__svg-pdf\" d=\"M23.83,125.68h22.36c5.29,0,9.41,1.33,12.35,4c2.94,2.67,4.42,6.39,4.42,11.18c0,4.78-1.47,8.51-4.42,11.18\n c-2.94,2.67-7.06,4-12.35,4H34.59v18.29H23.83V125.68z M44.81,147.9c5.38,0,8.07-2.32,8.07-6.97c0-2.39-0.67-4.16-2-5.31\n c-1.33-1.15-3.36-1.73-6.07-1.73H34.59v14.01H44.81z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M69.92,125.68h18.91c5.29,0,9.84,0.97,13.66,2.9c3.82,1.93,6.74,4.72,8.76,8.35\n c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">Technical Datasheet (14-1103)</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/manuals/cut-and-tag-kit.pdf\" target=\"_new\" class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0002 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n d=\"M191.92,68.77l-47.69-47.69c-1.33-1.33-3.12-2.08-5.01-2.08H45.09C41.17,19,38,22.17,38,26.09v184.36\n c0,3.92,3.17,7.09,7.09,7.09h141.82c3.92,0,7.09-3.17,7.09-7.09V73.8C194,71.92,193.25,70.1,191.92,68.77z M177.65,77.06h-41.7\n v-41.7L177.65,77.06z M178.05,201.59H53.95V34.95h66.92v47.86c0,5.14,4.17,9.31,9.31,9.31h47.86V201.59z\" />\n </g>\n <rect x=\"20\" y=\"112\" class=\"product-documents__svg-background\" width=\"146\" height=\"76\" />\n <g>\n <path class=\"product-documents__svg-pdf\" d=\"M23.83,125.68h22.36c5.29,0,9.41,1.33,12.35,4c2.94,2.67,4.42,6.39,4.42,11.18c0,4.78-1.47,8.51-4.42,11.18\n c-2.94,2.67-7.06,4-12.35,4H34.59v18.29H23.83V125.68z M44.81,147.9c5.38,0,8.07-2.32,8.07-6.97c0-2.39-0.67-4.16-2-5.31\n c-1.33-1.15-3.36-1.73-6.07-1.73H34.59v14.01H44.81z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M69.92,125.68h18.91c5.29,0,9.84,0.97,13.66,2.9c3.82,1.93,6.74,4.72,8.76,8.35\n c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">CUT&Tag Kit Manual</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/manuals/cut-and-tag-kit-quick-card.pdf\" target=\"_blank\"\n class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0002 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n d=\"M191.92,68.77l-47.69-47.69c-1.33-1.33-3.12-2.08-5.01-2.08H45.09C41.17,19,38,22.17,38,26.09v184.36\n c0,3.92,3.17,7.09,7.09,7.09h141.82c3.92,0,7.09-3.17,7.09-7.09V73.8C194,71.92,193.25,70.1,191.92,68.77z M177.65,77.06h-41.7\n v-41.7L177.65,77.06z M178.05,201.59H53.95V34.95h66.92v47.86c0,5.14,4.17,9.31,9.31,9.31h47.86V201.59z\" />\n </g>\n <rect x=\"20\" y=\"112\" class=\"product-documents__svg-background\" width=\"146\" height=\"76\" />\n <g>\n <path class=\"product-documents__svg-pdf\" d=\"M23.83,125.68h22.36c5.29,0,9.41,1.33,12.35,4c2.94,2.67,4.42,6.39,4.42,11.18c0,4.78-1.47,8.51-4.42,11.18\n c-2.94,2.67-7.06,4-12.35,4H34.59v18.29H23.83V125.68z M44.81,147.9c5.38,0,8.07-2.32,8.07-6.97c0-2.39-0.67-4.16-2-5.31\n c-1.33-1.15-3.36-1.73-6.07-1.73H34.59v14.01H44.81z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M69.92,125.68h18.91c5.29,0,9.84,0.97,13.66,2.9c3.82,1.93,6.74,4.72,8.76,8.35\n c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">\n CUT&Tag Kit Quick Card</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/SNAP-CUTANA_K-MetStat_Panel_ShellScript.sh\" target=\"_blank\"\n class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\">\n <g>\n <path class=\"product-documents__svg-txt\" d=\"M199.12,66.39l-51.16-51.16c-1.43-1.43-3.35-2.23-5.37-2.23H41.61c-4.2,0-7.61,3.41-7.61,7.61v197.79\n c0,4.2,3.41,7.61,7.61,7.61h152.14c4.2,0,7.61-3.41,7.61-7.61V71.79C201.36,69.77,200.55,67.82,199.12,66.39L199.12,66.39z\n M183.81,75.28h-44.74V30.54L183.81,75.28z M184.24,208.88H51.12V30.12h71.79v51.35c0,5.51,4.47,9.98,9.98,9.98h51.35V208.88z\n M115.78,144.7H72.04c-1.05,0-1.9,0.86-1.9,1.9v11.41c0,1.05,0.86,1.9,1.9,1.9h43.74c1.05,0,1.9-0.86,1.9-1.9V146.6\n C117.68,145.55,116.82,144.7,115.78,144.7z M70.13,114.27v11.41c0,1.05,0.86,1.9,1.9,1.9h91.29c1.05,0,1.9-0.86,1.9-1.9v-11.41\n c0-1.05-0.86-1.9-1.9-1.9H72.04C70.99,112.37,70.13,113.22,70.13,114.27z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">\n SNAP-CUTANA™ K-MetStat Panel Shell Script</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/SNAP-CUTANA_K-MetStat_Panel_Analysis.xlsx\" target=\"_blank\"\n class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\">\n <g>\n <path class=\"product-documents__svg-excel\"\n d=\"M193.17,69.88l-46.83-46.83c-1.31-1.31-3.07-2.05-4.92-2.05H48.96C45.11,21,42,24.11,42,27.96v181.07\n c0,3.85,3.11,6.96,6.96,6.96h139.29c3.85,0,6.96-3.11,6.96-6.96V74.82C195.21,72.97,194.47,71.19,193.17,69.88L193.17,69.88z\n M179.15,78.02h-40.96V37.06L179.15,78.02z M179.54,200.33H57.67V36.67h65.73v47.01c0,5.05,4.09,9.14,9.14,9.14h47.01V200.33z\n M119.06,133.32l-13.45-22.29c-0.48-0.78-2.24-1.24-2.24-1.24h-8.33c-0.5,0-0.98,0.13-1.39,0.41c-1.21,0.76-1.58,2.36-0.8,3.6\n l17.85,28.28l-18.08,28.8c-0.76,1.22-0.39,2.83,0.84,3.6c0.41,0.26,0.89,0.39,1.37,0.39h7.48c0,0,1.74-0.26,2.22-1.02l13.65-22.09\n l13.56,22.07c0.48,0.78,2.22,1.26,2.22,1.26h8.18c0.5,0,0.98-0.15,1.42-0.42c1.22-0.79,1.57-2.4,0.79-3.63l-18.35-28.48\n l18.63-28.94c0.78-1.23,0.42-2.85-0.81-3.63c-0.42-0.27-0.9-0.41-1.4-0.41h-7.79c0,0-1.76,0.7-2.24,1.48L119.06,133.32z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">SNAP-CUTANA™ K-MetStat Panel Analysis</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/manuals/CUT-and-Tag-multiplexing-primers.xlsx\" target=\"_blank\"\n class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\">\n <g>\n <path class=\"product-documents__svg-excel\"\n d=\"M193.17,69.88l-46.83-46.83c-1.31-1.31-3.07-2.05-4.92-2.05H48.96C45.11,21,42,24.11,42,27.96v181.07\n c0,3.85,3.11,6.96,6.96,6.96h139.29c3.85,0,6.96-3.11,6.96-6.96V74.82C195.21,72.97,194.47,71.19,193.17,69.88L193.17,69.88z\n M179.15,78.02h-40.96V37.06L179.15,78.02z M179.54,200.33H57.67V36.67h65.73v47.01c0,5.05,4.09,9.14,9.14,9.14h47.01V200.33z\n M119.06,133.32l-13.45-22.29c-0.48-0.78-2.24-1.24-2.24-1.24h-8.33c-0.5,0-0.98,0.13-1.39,0.41c-1.21,0.76-1.58,2.36-0.8,3.6\n l17.85,28.28l-18.08,28.8c-0.76,1.22-0.39,2.83,0.84,3.6c0.41,0.26,0.89,0.39,1.37,0.39h7.48c0,0,1.74-0.26,2.22-1.02l13.65-22.09\n l13.56,22.07c0.48,0.78,2.22,1.26,2.22,1.26h8.18c0.5,0,0.98-0.15,1.42-0.42c1.22-0.79,1.57-2.4,0.79-3.63l-18.35-28.48\n l18.63-28.94c0.78-1.23,0.42-2.85-0.81-3.63c-0.42-0.27-0.9-0.41-1.4-0.41h-7.79c0,0-1.76,0.7-2.24,1.48L119.06,133.32z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">CUT&Tag Multiplexing Primers</span>\n </a>\n </div>\n </div>\n </div>\n </div>\n\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel\">\n <!-- <h3 style=\"color: #4698cb; margin-bottom: 0\">Current Lot</h3> -->\n <h3 style=\"padding-bottom: 5px; margin-top: 1rem; padding-top: 0\" class=\"sub-title1\">\n Kit Version 2\n </h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description\">\n <div class=\"product-documents\">\n <a href=\"/content/documents/tds/14-1102-2.pdf\" target=\"_new\" class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0002 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n d=\"M191.92,68.77l-47.69-47.69c-1.33-1.33-3.12-2.08-5.01-2.08H45.09C41.17,19,38,22.17,38,26.09v184.36\n c0,3.92,3.17,7.09,7.09,7.09h141.82c3.92,0,7.09-3.17,7.09-7.09V73.8C194,71.92,193.25,70.1,191.92,68.77z M177.65,77.06h-41.7\n v-41.7L177.65,77.06z M178.05,201.59H53.95V34.95h66.92v47.86c0,5.14,4.17,9.31,9.31,9.31h47.86V201.59z\" />\n </g>\n <rect x=\"20\" y=\"112\" class=\"product-documents__svg-background\" width=\"146\" height=\"76\" />\n <g>\n <path class=\"product-documents__svg-pdf\" d=\"M23.83,125.68h22.36c5.29,0,9.41,1.33,12.35,4c2.94,2.67,4.42,6.39,4.42,11.18c0,4.78-1.47,8.51-4.42,11.18\n c-2.94,2.67-7.06,4-12.35,4H34.59v18.29H23.83V125.68z M44.81,147.9c5.38,0,8.07-2.32,8.07-6.97c0-2.39-0.67-4.16-2-5.31\n c-1.33-1.15-3.36-1.73-6.07-1.73H34.59v14.01H44.81z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M69.92,125.68h18.91c5.29,0,9.84,0.97,13.66,2.9c3.82,1.93,6.74,4.72,8.76,8.35\n c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">Technical Datasheet (14-1102)</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/tds/14-1103-2.pdf\" target=\"_new\" class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0002 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n d=\"M191.92,68.77l-47.69-47.69c-1.33-1.33-3.12-2.08-5.01-2.08H45.09C41.17,19,38,22.17,38,26.09v184.36\n c0,3.92,3.17,7.09,7.09,7.09h141.82c3.92,0,7.09-3.17,7.09-7.09V73.8C194,71.92,193.25,70.1,191.92,68.77z M177.65,77.06h-41.7\n v-41.7L177.65,77.06z M178.05,201.59H53.95V34.95h66.92v47.86c0,5.14,4.17,9.31,9.31,9.31h47.86V201.59z\" />\n </g>\n <rect x=\"20\" y=\"112\" class=\"product-documents__svg-background\" width=\"146\" height=\"76\" />\n <g>\n <path class=\"product-documents__svg-pdf\" d=\"M23.83,125.68h22.36c5.29,0,9.41,1.33,12.35,4c2.94,2.67,4.42,6.39,4.42,11.18c0,4.78-1.47,8.51-4.42,11.18\n c-2.94,2.67-7.06,4-12.35,4H34.59v18.29H23.83V125.68z M44.81,147.9c5.38,0,8.07-2.32,8.07-6.97c0-2.39-0.67-4.16-2-5.31\n c-1.33-1.15-3.36-1.73-6.07-1.73H34.59v14.01H44.81z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M69.92,125.68h18.91c5.29,0,9.84,0.97,13.66,2.9c3.82,1.93,6.74,4.72,8.76,8.35\n c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">Technical Datasheet (14-1103)</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/manuals/cut-and-tag-kit_2.0.pdf\" target=\"_new\" class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0002 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n d=\"M191.92,68.77l-47.69-47.69c-1.33-1.33-3.12-2.08-5.01-2.08H45.09C41.17,19,38,22.17,38,26.09v184.36\n c0,3.92,3.17,7.09,7.09,7.09h141.82c3.92,0,7.09-3.17,7.09-7.09V73.8C194,71.92,193.25,70.1,191.92,68.77z M177.65,77.06h-41.7\n v-41.7L177.65,77.06z M178.05,201.59H53.95V34.95h66.92v47.86c0,5.14,4.17,9.31,9.31,9.31h47.86V201.59z\" />\n </g>\n <rect x=\"20\" y=\"112\" class=\"product-documents__svg-background\" width=\"146\" height=\"76\" />\n <g>\n <path class=\"product-documents__svg-pdf\" d=\"M23.83,125.68h22.36c5.29,0,9.41,1.33,12.35,4c2.94,2.67,4.42,6.39,4.42,11.18c0,4.78-1.47,8.51-4.42,11.18\n c-2.94,2.67-7.06,4-12.35,4H34.59v18.29H23.83V125.68z M44.81,147.9c5.38,0,8.07-2.32,8.07-6.97c0-2.39-0.67-4.16-2-5.31\n c-1.33-1.15-3.36-1.73-6.07-1.73H34.59v14.01H44.81z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M69.92,125.68h18.91c5.29,0,9.84,0.97,13.66,2.9c3.82,1.93,6.74,4.72,8.76,8.35\n c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">CUT&Tag Kit Manual</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/manuals/cut-and-tag-kit-quick-card_2.0.pdf\" target=\"_blank\"\n class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0002 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n d=\"M191.92,68.77l-47.69-47.69c-1.33-1.33-3.12-2.08-5.01-2.08H45.09C41.17,19,38,22.17,38,26.09v184.36\n c0,3.92,3.17,7.09,7.09,7.09h141.82c3.92,0,7.09-3.17,7.09-7.09V73.8C194,71.92,193.25,70.1,191.92,68.77z M177.65,77.06h-41.7\n v-41.7L177.65,77.06z M178.05,201.59H53.95V34.95h66.92v47.86c0,5.14,4.17,9.31,9.31,9.31h47.86V201.59z\" />\n </g>\n <rect x=\"20\" y=\"112\" class=\"product-documents__svg-background\" width=\"146\" height=\"76\" />\n <g>\n <path class=\"product-documents__svg-pdf\" d=\"M23.83,125.68h22.36c5.29,0,9.41,1.33,12.35,4c2.94,2.67,4.42,6.39,4.42,11.18c0,4.78-1.47,8.51-4.42,11.18\n c-2.94,2.67-7.06,4-12.35,4H34.59v18.29H23.83V125.68z M44.81,147.9c5.38,0,8.07-2.32,8.07-6.97c0-2.39-0.67-4.16-2-5.31\n c-1.33-1.15-3.36-1.73-6.07-1.73H34.59v14.01H44.81z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M69.92,125.68h18.91c5.29,0,9.84,0.97,13.66,2.9c3.82,1.93,6.74,4.72,8.76,8.35\n c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">\n CUT&Tag Kit Quick Card</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/SNAP-CUTANA_K-MetStat_Panel_ShellScript.sh\" target=\"_blank\"\n class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\">\n <g>\n <path class=\"product-documents__svg-txt\" d=\"M199.12,66.39l-51.16-51.16c-1.43-1.43-3.35-2.23-5.37-2.23H41.61c-4.2,0-7.61,3.41-7.61,7.61v197.79\n c0,4.2,3.41,7.61,7.61,7.61h152.14c4.2,0,7.61-3.41,7.61-7.61V71.79C201.36,69.77,200.55,67.82,199.12,66.39L199.12,66.39z\n M183.81,75.28h-44.74V30.54L183.81,75.28z M184.24,208.88H51.12V30.12h71.79v51.35c0,5.51,4.47,9.98,9.98,9.98h51.35V208.88z\n M115.78,144.7H72.04c-1.05,0-1.9,0.86-1.9,1.9v11.41c0,1.05,0.86,1.9,1.9,1.9h43.74c1.05,0,1.9-0.86,1.9-1.9V146.6\n C117.68,145.55,116.82,144.7,115.78,144.7z M70.13,114.27v11.41c0,1.05,0.86,1.9,1.9,1.9h91.29c1.05,0,1.9-0.86,1.9-1.9v-11.41\n c0-1.05-0.86-1.9-1.9-1.9H72.04C70.99,112.37,70.13,113.22,70.13,114.27z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">\n SNAP-CUTANA™ K-MetStat Panel Shell Script</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/SNAP-CUTANA_K-MetStat_Panel_Analysis.xlsx\" target=\"_blank\"\n class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\">\n <g>\n <path class=\"product-documents__svg-excel\"\n d=\"M193.17,69.88l-46.83-46.83c-1.31-1.31-3.07-2.05-4.92-2.05H48.96C45.11,21,42,24.11,42,27.96v181.07\n c0,3.85,3.11,6.96,6.96,6.96h139.29c3.85,0,6.96-3.11,6.96-6.96V74.82C195.21,72.97,194.47,71.19,193.17,69.88L193.17,69.88z\n M179.15,78.02h-40.96V37.06L179.15,78.02z M179.54,200.33H57.67V36.67h65.73v47.01c0,5.05,4.09,9.14,9.14,9.14h47.01V200.33z\n M119.06,133.32l-13.45-22.29c-0.48-0.78-2.24-1.24-2.24-1.24h-8.33c-0.5,0-0.98,0.13-1.39,0.41c-1.21,0.76-1.58,2.36-0.8,3.6\n l17.85,28.28l-18.08,28.8c-0.76,1.22-0.39,2.83,0.84,3.6c0.41,0.26,0.89,0.39,1.37,0.39h7.48c0,0,1.74-0.26,2.22-1.02l13.65-22.09\n l13.56,22.07c0.48,0.78,2.22,1.26,2.22,1.26h8.18c0.5,0,0.98-0.15,1.42-0.42c1.22-0.79,1.57-2.4,0.79-3.63l-18.35-28.48\n l18.63-28.94c0.78-1.23,0.42-2.85-0.81-3.63c-0.42-0.27-0.9-0.41-1.4-0.41h-7.79c0,0-1.76,0.7-2.24,1.48L119.06,133.32z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">SNAP-CUTANA™ K-MetStat Panel Analysis</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/manuals/CUT-and-Tag-multiplexing-primers.xlsx\" target=\"_blank\"\n class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\">\n <g>\n <path class=\"product-documents__svg-excel\"\n d=\"M193.17,69.88l-46.83-46.83c-1.31-1.31-3.07-2.05-4.92-2.05H48.96C45.11,21,42,24.11,42,27.96v181.07\n c0,3.85,3.11,6.96,6.96,6.96h139.29c3.85,0,6.96-3.11,6.96-6.96V74.82C195.21,72.97,194.47,71.19,193.17,69.88L193.17,69.88z\n M179.15,78.02h-40.96V37.06L179.15,78.02z M179.54,200.33H57.67V36.67h65.73v47.01c0,5.05,4.09,9.14,9.14,9.14h47.01V200.33z\n M119.06,133.32l-13.45-22.29c-0.48-0.78-2.24-1.24-2.24-1.24h-8.33c-0.5,0-0.98,0.13-1.39,0.41c-1.21,0.76-1.58,2.36-0.8,3.6\n l17.85,28.28l-18.08,28.8c-0.76,1.22-0.39,2.83,0.84,3.6c0.41,0.26,0.89,0.39,1.37,0.39h7.48c0,0,1.74-0.26,2.22-1.02l13.65-22.09\n l13.56,22.07c0.48,0.78,2.22,1.26,2.22,1.26h8.18c0.5,0,0.98-0.15,1.42-0.42c1.22-0.79,1.57-2.4,0.79-3.63l-18.35-28.48\n l18.63-28.94c0.78-1.23,0.42-2.85-0.81-3.63c-0.42-0.27-0.9-0.41-1.4-0.41h-7.79c0,0-1.76,0.7-2.24,1.48L119.06,133.32z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">CUT&Tag Multiplexing Primers</span>\n </a>\n </div>\n </div>\n </div>\n </div>\n\n <div id=\"prodAccordion\">\n <div id=\"ProductDescription\" class=\"Block Panel\">\n <!-- <h3 style=\"color: #4698cb; margin-bottom: 0\">Current Lot</h3> -->\n <h3 style=\"padding-bottom: 5px; margin-top: 1rem; padding-top: 0\" class=\"sub-title1\">\n Kit Version 1\n </h3>\n <div class=\"ProductDescriptionContainer product-droppdown__section-description\">\n <div class=\"product-documents\">\n <a href=\"/content/documents/tds/14-1102-1.pdf\" target=\"_new\" class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0002 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n d=\"M191.92,68.77l-47.69-47.69c-1.33-1.33-3.12-2.08-5.01-2.08H45.09C41.17,19,38,22.17,38,26.09v184.36\n c0,3.92,3.17,7.09,7.09,7.09h141.82c3.92,0,7.09-3.17,7.09-7.09V73.8C194,71.92,193.25,70.1,191.92,68.77z M177.65,77.06h-41.7\n v-41.7L177.65,77.06z M178.05,201.59H53.95V34.95h66.92v47.86c0,5.14,4.17,9.31,9.31,9.31h47.86V201.59z\" />\n </g>\n <rect x=\"20\" y=\"112\" class=\"product-documents__svg-background\" width=\"146\" height=\"76\" />\n <g>\n <path class=\"product-documents__svg-pdf\" d=\"M23.83,125.68h22.36c5.29,0,9.41,1.33,12.35,4c2.94,2.67,4.42,6.39,4.42,11.18c0,4.78-1.47,8.51-4.42,11.18\n c-2.94,2.67-7.06,4-12.35,4H34.59v18.29H23.83V125.68z M44.81,147.9c5.38,0,8.07-2.32,8.07-6.97c0-2.39-0.67-4.16-2-5.31\n c-1.33-1.15-3.36-1.73-6.07-1.73H34.59v14.01H44.81z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M69.92,125.68h18.91c5.29,0,9.84,0.97,13.66,2.9c3.82,1.93,6.74,4.72,8.76,8.35\n c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">Technical Datasheet (14-1102)</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/tds/14-1103-1.pdf\" target=\"_new\" class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0002 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n d=\"M191.92,68.77l-47.69-47.69c-1.33-1.33-3.12-2.08-5.01-2.08H45.09C41.17,19,38,22.17,38,26.09v184.36\n c0,3.92,3.17,7.09,7.09,7.09h141.82c3.92,0,7.09-3.17,7.09-7.09V73.8C194,71.92,193.25,70.1,191.92,68.77z M177.65,77.06h-41.7\n v-41.7L177.65,77.06z M178.05,201.59H53.95V34.95h66.92v47.86c0,5.14,4.17,9.31,9.31,9.31h47.86V201.59z\" />\n </g>\n <rect x=\"20\" y=\"112\" class=\"product-documents__svg-background\" width=\"146\" height=\"76\" />\n <g>\n <path class=\"product-documents__svg-pdf\" d=\"M23.83,125.68h22.36c5.29,0,9.41,1.33,12.35,4c2.94,2.67,4.42,6.39,4.42,11.18c0,4.78-1.47,8.51-4.42,11.18\n c-2.94,2.67-7.06,4-12.35,4H34.59v18.29H23.83V125.68z M44.81,147.9c5.38,0,8.07-2.32,8.07-6.97c0-2.39-0.67-4.16-2-5.31\n c-1.33-1.15-3.36-1.73-6.07-1.73H34.59v14.01H44.81z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M69.92,125.68h18.91c5.29,0,9.84,0.97,13.66,2.9c3.82,1.93,6.74,4.72,8.76,8.35\n c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">Technical Datasheet (14-1103)</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/manuals/cut-and-tag-kit_1.1.pdf\" target=\"_new\" class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0002 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n d=\"M191.92,68.77l-47.69-47.69c-1.33-1.33-3.12-2.08-5.01-2.08H45.09C41.17,19,38,22.17,38,26.09v184.36\n c0,3.92,3.17,7.09,7.09,7.09h141.82c3.92,0,7.09-3.17,7.09-7.09V73.8C194,71.92,193.25,70.1,191.92,68.77z M177.65,77.06h-41.7\n v-41.7L177.65,77.06z M178.05,201.59H53.95V34.95h66.92v47.86c0,5.14,4.17,9.31,9.31,9.31h47.86V201.59z\" />\n </g>\n <rect x=\"20\" y=\"112\" class=\"product-documents__svg-background\" width=\"146\" height=\"76\" />\n <g>\n <path class=\"product-documents__svg-pdf\" d=\"M23.83,125.68h22.36c5.29,0,9.41,1.33,12.35,4c2.94,2.67,4.42,6.39,4.42,11.18c0,4.78-1.47,8.51-4.42,11.18\n c-2.94,2.67-7.06,4-12.35,4H34.59v18.29H23.83V125.68z M44.81,147.9c5.38,0,8.07-2.32,8.07-6.97c0-2.39-0.67-4.16-2-5.31\n c-1.33-1.15-3.36-1.73-6.07-1.73H34.59v14.01H44.81z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M69.92,125.68h18.91c5.29,0,9.84,0.97,13.66,2.9c3.82,1.93,6.74,4.72,8.76,8.35\n c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">CUT&Tag Kit Manual</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/manuals/cut-and-tag-kit-quick-card_1.1.pdf\" target=\"_blank\"\n class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\"\n alt=\"16-0002 Datasheet\">\n <g>\n <path class=\"product-documents__svg-pdf\"\n d=\"M191.92,68.77l-47.69-47.69c-1.33-1.33-3.12-2.08-5.01-2.08H45.09C41.17,19,38,22.17,38,26.09v184.36\n c0,3.92,3.17,7.09,7.09,7.09h141.82c3.92,0,7.09-3.17,7.09-7.09V73.8C194,71.92,193.25,70.1,191.92,68.77z M177.65,77.06h-41.7\n v-41.7L177.65,77.06z M178.05,201.59H53.95V34.95h66.92v47.86c0,5.14,4.17,9.31,9.31,9.31h47.86V201.59z\" />\n </g>\n <rect x=\"20\" y=\"112\" class=\"product-documents__svg-background\" width=\"146\" height=\"76\" />\n <g>\n <path class=\"product-documents__svg-pdf\" d=\"M23.83,125.68h22.36c5.29,0,9.41,1.33,12.35,4c2.94,2.67,4.42,6.39,4.42,11.18c0,4.78-1.47,8.51-4.42,11.18\n c-2.94,2.67-7.06,4-12.35,4H34.59v18.29H23.83V125.68z M44.81,147.9c5.38,0,8.07-2.32,8.07-6.97c0-2.39-0.67-4.16-2-5.31\n c-1.33-1.15-3.36-1.73-6.07-1.73H34.59v14.01H44.81z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M69.92,125.68h18.91c5.29,0,9.84,0.97,13.66,2.9c3.82,1.93,6.74,4.72,8.76,8.35\n c2.02,3.63,3.04,7.98,3.04,13.04c0,5.06-1,9.42-3,13.08c-2,3.66-4.91,6.45-8.73,8.38c-3.82,1.93-8.4,2.9-13.73,2.9H69.92V125.68z\n M88.07,165.63c10.35,0,15.52-5.22,15.52-15.66c0-10.4-5.17-15.59-15.52-15.59h-7.38v31.26H88.07z\" />\n <path class=\"product-documents__svg-pdf\"\n d=\"M122.57,125.68h32.84v8.49h-22.22v11.18h20.84v8.49h-20.84v20.49h-10.63V125.68z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">\n CUT&Tag Kit Quick Card</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/SNAP-CUTANA_K-MetStat_Panel_ShellScript.sh\" target=\"_blank\"\n class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\">\n <g>\n <path class=\"product-documents__svg-txt\" d=\"M199.12,66.39l-51.16-51.16c-1.43-1.43-3.35-2.23-5.37-2.23H41.61c-4.2,0-7.61,3.41-7.61,7.61v197.79\n c0,4.2,3.41,7.61,7.61,7.61h152.14c4.2,0,7.61-3.41,7.61-7.61V71.79C201.36,69.77,200.55,67.82,199.12,66.39L199.12,66.39z\n M183.81,75.28h-44.74V30.54L183.81,75.28z M184.24,208.88H51.12V30.12h71.79v51.35c0,5.51,4.47,9.98,9.98,9.98h51.35V208.88z\n M115.78,144.7H72.04c-1.05,0-1.9,0.86-1.9,1.9v11.41c0,1.05,0.86,1.9,1.9,1.9h43.74c1.05,0,1.9-0.86,1.9-1.9V146.6\n C117.68,145.55,116.82,144.7,115.78,144.7z M70.13,114.27v11.41c0,1.05,0.86,1.9,1.9,1.9h91.29c1.05,0,1.9-0.86,1.9-1.9v-11.41\n c0-1.05-0.86-1.9-1.9-1.9H72.04C70.99,112.37,70.13,113.22,70.13,114.27z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">\n SNAP-CUTANA™ K-MetStat Panel Shell Script</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/SNAP-CUTANA_K-MetStat_Panel_Analysis.xlsx\" target=\"_blank\"\n class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\">\n <g>\n <path class=\"product-documents__svg-excel\"\n d=\"M193.17,69.88l-46.83-46.83c-1.31-1.31-3.07-2.05-4.92-2.05H48.96C45.11,21,42,24.11,42,27.96v181.07\n c0,3.85,3.11,6.96,6.96,6.96h139.29c3.85,0,6.96-3.11,6.96-6.96V74.82C195.21,72.97,194.47,71.19,193.17,69.88L193.17,69.88z\n M179.15,78.02h-40.96V37.06L179.15,78.02z M179.54,200.33H57.67V36.67h65.73v47.01c0,5.05,4.09,9.14,9.14,9.14h47.01V200.33z\n M119.06,133.32l-13.45-22.29c-0.48-0.78-2.24-1.24-2.24-1.24h-8.33c-0.5,0-0.98,0.13-1.39,0.41c-1.21,0.76-1.58,2.36-0.8,3.6\n l17.85,28.28l-18.08,28.8c-0.76,1.22-0.39,2.83,0.84,3.6c0.41,0.26,0.89,0.39,1.37,0.39h7.48c0,0,1.74-0.26,2.22-1.02l13.65-22.09\n l13.56,22.07c0.48,0.78,2.22,1.26,2.22,1.26h8.18c0.5,0,0.98-0.15,1.42-0.42c1.22-0.79,1.57-2.4,0.79-3.63l-18.35-28.48\n l18.63-28.94c0.78-1.23,0.42-2.85-0.81-3.63c-0.42-0.27-0.9-0.41-1.4-0.41h-7.79c0,0-1.76,0.7-2.24,1.48L119.06,133.32z\" />\n </g>\n </svg>\n <span class=\"product-documents__info\">SNAP-CUTANA™ K-MetStat Panel Analysis</span>\n </a>\n </div>\n <div class=\"product-documents\">\n <a href=\"/content/documents/manuals/CUT-and-Tag-multiplexing-primers.xlsx\" target=\"_blank\"\n class=\"product-documents__link\">\n <svg version=\"1.1\" id=\"Layer_1\" xmlns=\"http://www.w3.org/2000/svg\"\n xmlns:xlink=\"http://www.w3.org/1999/xlink\" x=\"0px\" y=\"0px\" viewBox=\"0 0 228 240\"\n style=\"enable-background: new 0 0 228 240\" xml:space=\"preserve\" class=\"product-documents__icon\">\n <g>\n <path class=\"product-documents__svg-excel\"\n d=\"M193.17,69.88l-46.83-46.83c-1.31-1.31-3.07-2.05-4.92-2.05H48.96C45.11,21,42,24.11,42,27.96v181.07\n 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class=\"sub-title1\">\n Product References\n </h3>\n\n <div class=\"ProductDescriptionContainer product-droppdown__section-description-specific\">\n <object id=\"wobj-3835-14-1102-q\" type=\"text/html\" data=\"https://www.bioz.com/v_widget_6_0/3835/14-1102/\"\n style=\"width: 100%; height: 193px\"></object>\n <div id=\"bioz-w-pb-3835-14-1102-q-div\" style=\"width: 100%\">\n <a id=\"bioz-w-pb-3835-14-1102-q\" style=\"\n font-size: 12px;\n text-decoration: none;\n color: #4698cb;\n \" href=\"https://www.bioz.com/\" target=\"_blank\"><img src=\"https://cdn.bioz.com/assets/favicon.png\" style=\"\n width: 11px;\n height: 11px;\n vertical-align: baseline;\n padding-bottom: 0px;\n margin-left: 0px;\n margin-bottom: 0px;\n float: none;\n \" />\n Powered by Bioz</a>\n <a style=\"\n font-size: 12px;\n text-decoration: none;\n float: right;\n color: transparent;\n \" href=\"https://www.bioz.com/result/14-1102/product/EpiCypher/?cn=14-1102\" target=\"_blank\">\n See more details on Bioz</a>\n 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Description
The CUTANA™ CUT&Tag Kit offers a comprehensive solution for ultra-sensitive mapping of histone post-translational modifications (PTMs) [Kaya-Okur et al., 2019]. This 48 reaction kit uses an exclusive Direct-to-PCR strategy to go from cells to PCR amplified sequencing libraries in one tube, bypassing traditional library prep and minimizing sample loss [Kaya-Okur et al., 2020]. The protocol is also designed for compatibility with multi-channel pipetting for increased throughput and reproducibility. Positive (H3K27me3 and H3K4me3) and negative (IgG) control antibodies are paired with the SNAP-CUTANA™ K-MetStat Panel of nucleosome spike-in controls (Figure 2) to continuously monitor workflows and guide troubleshooting.
The recommended input for CUT&Tag is 100,000 native nuclei per reaction. Comparable data can be generated down to 10,000 nuclei, and the protocol is also validated for whole cells, cryopreserved samples, and lightly cross-linked nuclei or cells. CUT&Tag provides robust profiling for histone PTMs. For chromatin-associated proteins (e.g. transcription factors), CUTANA™ CUT&RUN is recommended (EpiCypher 14-1048, EpiCypher 14-1001/14-1002).
Validation Data
Figure 1: CUT&Tag DNA fragment size distribution
analysis
CUT&Tag was performed as described in
Figure 5. Library DNA was analyzed by
Agilent TapeStation®, which confirmed that
mononucleosomes were predominantly enriched in CUT&Tag
(peak between 300-400 bp). Peak between 500-700 bp
represents dinucleosomes.
Figure 2: SNAP-CUTANA™ K-MetStat Spike-in
controls
DNA-barcoded designer nucleosomes (dNucs) representing 16 different K-methyl PTM states: mono-, di-,
and tri-methylation at H3K4, H3K9, H3K27, H3K36, and H4K20, as well as unmodified control, were
spiked into CUT&Tag samples prior to the addition of the control antibodies provided with the kit
(IgG, H3K27me3, H3K4me3). After sequencing, instances of each spike-in barcode recovered in the
CUT&Tag reactions were counted and normalized from raw fastq files using the shell script and
analysis Excel sheet available on the spike-in product page (EpiCypher 19-1002). Barcodes
for IgG
(top; normalized to the sum of total reads), H3K27me3 (middle; normalized to on-target), and H3K4me3
(bottom; normalized to on-target) antibodies provided with this kit are shown. The spike-ins
confirmed optimal experimental conditions (H3K27me3 and H3K4me3 antibodies specifically recovered
the target dNuc, while IgG showed no preferential enrichment).
Figure 3: CUT&Tag genome-wide heatmaps
CUT&Tag was performed as described in Figure 5. Heatmaps show two replicates
(“Rep”) of IgG and
H3K4me3 antibodies in aligned rows ranked by intensity (top to bottom) relative to the H3K4me3 Rep 1
reaction. High, medium, and low intensity are shown in red, yellow, and blue, respectively.
Antibodies to histone PTMs showed expected enrichment patterns and high reproducibility. H3K4me3, a
marker of active transcription localized to transcription start sites (TSSs), shows enrichment
consistent at TSSs, as expected. IgG shows low background enrichment.
Figure 4: Representative gene browser
tracks
CUT&Tag was performed as described in Figure 5. A representative 186 kb window at
the LAMC3 gene is
shown for two replicates (“Rep”) of IgG, H3K27me3, and H3K4me3 kit control antibodies.
Representative tracks are also shown for two replicates of H3K4me1 antibody. The CUT&Tag kit
produced the expected genomic distribution for each target. Images were generated using the
Integrative Genomics Viewer (IGV, Broad Institute).
Figure 5: CUT&Tag methods
CUT&Tag was performed using the CUTANA™ CUT&Tag Kit starting with 100k K562 cells and 0.5 µg of
either IgG (EpiCypher 13-0042t), H3K27me3 (EpiCypher 13-0055t), H3K4me3 (EpiCypher 13-0060t), or
H3K4me1 (EpiCypher 13-0057) antibodies. Libraries were run on an Illumina NextSeq2000 with
paired-end sequencing (2x50 bp). Sample sequencing depth was 5.3/4.1 million reads (IgG Rep 1/Rep
2), 11.2/9.0 million reads (H3K27me3 Rep 1/Rep 2), 8.6/5.0 million reads (H3K4me3 Rep 1/Rep 2), and
4.1/10.3 million reads (H3K4me1 Rep 1/Rep 2). Data were aligned to the hg19 genome using Bowtie2.
Data were filtered to remove duplicates, multi-aligned reads, and ENCODE DAC Exclusion List regions.
Kit Contents
Item | Cat. No. |
---|---|
CUTANA™ pAG-Tn5 for CUT&Tag | 15-1017t |
H3K27me3 Antibody, SNAP-Certified™ for CUT&RUN and CUT&Tag | 13-0055t |
H3K4me3 Antibody, SNAP-Certified™ for CUT&RUN and CUT&Tag | 13-0060t |
CUTANA™ Rabbit IgG CUT&RUN Negative Control Antibody | 13-0042t |
Anti-Rabbit Secondary Antibody for CUTANA™ CUT&Tag Workflows | 13-0047t |
SNAP-CUTANA™ K-MetStat Panel | 19-1002t |
CUTANA™ Concanavalin A Conjugated Paramagnetic Beads | 21-1401t |
CUTANA™ Non-Hot Start 2X PCR Master Mix for CUT&Tag | 15-1018t |
CUTANA™ CUT&RUN 8-strip 0.2 mL Tubes | 10-0009t |
4.5 M NaCl | 21-1013t |
0.5 M EDTA | 21-1006t |
1 M MgCl2 | 21-1015t |
SDS Release Buffer | 21-1017t |
SDS Quench Buffer | 21-1018t |
0.1X TE Buffer | 21-1025t |
Pre-Wash Buffer | 21-1002t |
Pre-Nuclear Extraction Buffer | 21-1021t |
Bead Activation Buffer | 21-1001t |
5% Digitonin | 21-1004t |
1 M Spermidine | 21-1005t |
SPRIselect reagent manufactured by Beckman Coulter, Inc | 21-1405t |
Multiplexing Primers | 14-1102 and 14-1103 each contain combinatorial dual indices for multiplexed sequencing of up to 48 reactions. Combine the kits to multiplex up to 96 reactions. |
Recommended Accessory Products
Item | Cat. No. |
---|---|
Anti-Mouse Secondary Antibody for CUTANA™ CUT&Tag Workflows | 13-0048 |
SNAP-CUTANA™ K-MetStat Panel | 19-1002 |
CUT&Tag Antibodies | See the list |
Magnetic Separation Rack, 0.2 mL Tubes | 10-0008 |
Magnetic Separation Rack, 1.5 mL Tubes | 10-0012 |
Technical Information
Additional Information
Beckman Coulter, the stylized logo, and SPRIselect are trademarks or registered trademarks of Beckman Coulter, Inc. in the United States and other countries.