Methyl DNA Designer Nucleosomes

DNA methylation is one of the most well-studied epigenetic modifications, and has known roles in regulating gene expression and genomic stability. EpiCypher methyl DNA designer nucleosomes (MeDNA dNucs) are unmodified nucleosomes wrapped with unmethylated or hemi-methylated DNA, and are the optimal substrates for interrogating the function of DNA methylation on the binding activity of chromatin-associated proteins or inhibitors.

Shop MeDNA dNucs

Three ways to use MeDNA dNucs to explore chromatin function

Study impact of MeDNA dNucs on chromatin modifying enzymes
Use MeDNA dNucs as substrates to identify methylation-sensitive inhibitors
Apply to high-throughput screening

Learn more:

Recombinant Nucleosomes Brochure
Interested in using dNucs to study chromatin remodeling? Learn about EpiDyne® here!
How can dNucs be used to study chromatin reader interactions? See our dCypher™ Tech Note
How do we quantify our nucleosomes? See our Nucleosome Quantification Method

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