DNA methylation is one of the most well-studied epigenetic modifications, and has known roles in regulating gene expression and genomic stability. EpiCypher methyl DNA designer nucleosomes (MeDNA dNucs) are unmodified nucleosomes wrapped with unmethylated or hemi-methylated DNA, and are the optimal substrates for interrogating the function of DNA methylation on the binding activity of chromatin-associated proteins or inhibitors.
<div class="snap-chik-content"> <p>DNA methylation is one of the most well-studied epigenetic modifications, and has known roles in regulating gene expression and genomic stability. EpiCypher methyl DNA designer nucleosomes (MeDNA dNucs) are unmodified nucleosomes wrapped with unmethylated or hemi-methylated DNA, and are the optimal substrates for interrogating the function of DNA methylation on the binding activity of chromatin-associated proteins or inhibitors.</p> <div class="custom-btns-block"> <a href="https://www.epicypher.com/methyl-dna-designer-nucleosomes/#mednucsprods" class="button snap-chip-custom-btn">Shop MeDNA dNucs</a> </div> <p></p> <h5>Three ways to use MeDNA dNucs to explore chromatin function</h5> <ul> <li>Study impact of MeDNA dNucs on chromatin modifying enzymes</li> <li>Use MeDNA dNucs as substrates to identify methylation-sensitive inhibitors </li> <li>Apply to high-throughput screening</li> </ul> <h5>Learn more:</h5> <ul> <li><a href="/content/documents/brochures/rnucs.pdf/">Recombinant Nucleosomes Brochure</a></li> <li>Interested in using dNucs to study chromatin remodeling? <a href="/blog/epidyne-exploring-chromatin-remodeling-substrates-with-nucleosomes/">Learn about EpiDyne® here!</a></li> <li>How can dNucs be used to study chromatin reader interactions?<a href="/content/documents/technotes/dCypher_TechNote.pdf/"> See our dCypher® Tech Note</a></li> <h5>Shop related products and services:</h5> <ul class="category-nav-list"> <li><a href="/recombinant-nucleosomes/"> All Nucleosomes</a></li> <li><a href="/epidyne-chromatin-remodeling-substrates/">EpiDyne® Chromatin Remodeling Substrates</a></li> </ul> <a name="mednucsprods"></a>
