$115.00
Methyl DNA Designer Nucleosomes
DNA methylation is one of the most well-studied epigenetic modifications, and has known roles in regulating gene expression and genomic stability. EpiCypher methyl DNA designer nucleosomes (MeDNA dNucs) are unmodified nucleosomes wrapped with unmethylated or hemi-methylated DNA, and are the optimal substrates for interrogating the function of DNA methylation on the binding activity of chromatin-associated proteins or inhibitors.
Three ways to use MeDNA dNucs to explore chromatin function
- Study impact of MeDNA dNucs on chromatin modifying enzymes
- Use MeDNA dNucs as substrates to identify methylation-sensitive inhibitors
- Apply to high-throughput screening
Learn more:
- Recombinant Nucleosomes Brochure
- Interested in using dNucs to study chromatin remodeling? Learn about EpiDyne® here!
- How can dNucs be used to study chromatin reader interactions? See our dCypher™ Tech Note
- How do we quantify our nucleosomes? See our Nucleosome Quantification Method
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