Chromatin Mapping Basics: ChIP-seq
Even if you are new to epigenetics, you have probably heard of ChIP-seq,
CUT&RUN, and CUT&Tag – but how do these assays work? And
why do scientists use them? E…
About Us
EpiCypher® works with leaders in the field to deliver innovative solutions that meet scientists’ most challenging research needs. We have pioneered the development of modified designer nucleosomes (dNucs) and are applying these physiological substrates to develop next-generation biochemical and epigenomics technologies. As your research partner, we will provide cutting-edge tools and services for epigenetics and chromatin biology research. How can we help you Bring Epigenetics to Life?
Request Info
CUTANA™ ChIC / CUT&Tag Assays
Ultra-sensitive genomic profiling assays with lower input and sequencing read depth requirements than ChIP
Learn More
SNAP-ChIP® spike-ins
Accurate ChIP-seq antibody validation and data normalization using DNA-barcoded nucleosome spike-ins
Learn More
CUTANA™ ChIC / CUT&RUN Assays
Robust, high-resolution chromatin profiling, at a fraction of the time and cost of ChIP-seq
Learn More
Featured Products
-
SNAP-ChIP® spike-ins
DNA-barcoded recombinant nucleosome spike-ins provide unprecedented control over ChIP-seq experimentsView -
Modified Designer Nucleosomes (dNucs™)
Rigorously validated nucleosomes containing distinct histone PTMs for high-quality chromatin researchView -
dCypher™ Nucleosome Panels
Unrivaled nucleosome diversity in a convenient 96-well plate format, ideal for high-throughput screeningView -
EpiDyne® Chromatin Remodeling Substrates
Direct quantification of nucleosome remodeling activity, compatible with diverse assay readoutsView -
Recombinant Nucleosomes (rNucs)
Highly pure, unmodified nucleosomes are the preferred substrate for many chromatin-interacting proteinsView -
Purified Nucleosomes (HeLa, Avian)
Excellent controls for western blotting, testing enzymatic activity, and much moreView -
Nucleosome Components and Subunits
Highly pure and validated reagents for building your own customized nucleosomesView -
Variant Nucleosomes (vNucs)
Validated nucleosome substrates containing defined histone variantsView -
Oncogenic Nucleosomes (oncoNucs)
Recombinant nucleosomes containing histones with defined oncogenic mutations for cancer researchView -
Methyl DNA Designer Nucleosomes
Purified nucleosomes wrapped with hemi-methylated or unmethylated DNAView
Services
SNAP-ChIP® Antibody Validation
SNAP-ChIP® antibody validation services identify high-performance ChIP antibodies with superior specificity and enrichment, all within the context of a ChIP experiment.
Learn MoreEpiDyne® Chromatin Remodeling HTS Assays
EpiDyne® enables direct detection of chromatin remodeling activity, and is ideal for HTS and inhibitor profiling. EpiDyne services accelerate assay development and generate robust results.
Learn MoredCypher™ Assay Services for Novel Chromatin Interactions
dCypher™ assay services rapidly interrogate chromatin reader binding against a collection of modified histone peptides or nucleosomes, revealing novel mechanisms in chromatin biology.
Learn MoreCustom Nucleosome Development
Nucleosomes are the preferred target of chromatin interacting proteins, and are optimal substrates for epigenetics research. To address this need, EpiCypher provides custom nucleosome development.
Learn More
Our Thoughts
Check in for the latest in EpiCypher technology, chromatin research, and conference news!
Deciphering the Histone Code with the dCypher™ Platform
Many nuclear processes are coordinated by the activity of chromatin associated
proteins (CAPs) which add, remove, and recognize specific histone
post-translati…
CUT&RUN Just Got Easier
EpiCypher is leading the development of user-friendly solutions for emerging
epigenomic mapping technologies. Our recently launched
CUTANA™ CUT&RUN Library Pre…
A pioneer in the field of epigenetics and chromatin biology, EpiCypher is a biotechnology company developing transformative technologies to advance chromatin science and improve human health.
EpiCypher manufactures and sells a series of products and assay platforms that use recombinant “designer” nucleosomes (dNucs), including SNAP-ChIP® for quantitative ChIP applications,
EpiDyne® for nucleosome remodeling assays, dCypher™ to interrogate epigenetic regulators, recombinant histone binding proteins and enzymes, peptides and antibodies; and a broad range of custom substrate / assay development services.
Have questions? Feel free to give us a call!
+1-855-374-2461