The best histone PTM antibodies. Period.

EpiCypher takes a unique approach to validating histone post-translational modification (PTM) antibodies. Our exclusive SNAP Spike-in technology is the only method that uses physiological nucleosome controls to directly quantify antibody performance in genomic mapping workflows. The resulting SNAP-Certified™ Antibodies have multiple advantages over competitors:

  • Superior target specificity and affinity
  • Robust performance in epigenomic assays
  • Improved PTM profiling from low cell numbers
  • Increased reliability through lot-specific testing

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If you can’t trust your antibody, you can’t trust your data

Work by EpiCypher and others show that over 70% of antibodies to histone PTMs have unacceptable rates of cross-reactivity and poor target affinity. These results challenge our understanding of PTM biology and demand new tools for improved chromatin mapping.

SNAP Spike-in Certification is the only method that directly quantifies histone PTM antibody specificity and binding efficiency in genomic mapping assays (see Figure).

Don’t question your results – EpiCypher offers the best PTM antibodies.

Robust validation metrics for exceptional antibodies

The only fit-for-purpose antibodies for epigenomics

Specificity is Crucial

Valid biological interpretations from chromatin mapping data require specific antibodies.

Standard validation methods cannot distinguish specific vs. nonspecific PTM antibodies. Even highly cited antibodies fail to meet minimal expectations for on-target profiling (see Figure).

SNAP-Certified Antibodies exhibit less than 20% cross-reactivity, ensuring reliable data with exquisite accuracy.

Efficiency Matters

Highly efficient antibodies increase assay signal, enabling reliable mapping from reduced cell numbers.

However, the historical focus on PTM specificity means that most antibodies lack the efficiency required for low- or single-cell mapping.

SNAP-Certified Antibodies are validated for high efficiency and generate reproducible profiles in cell titrations (see Figure).

Interested in SNAP-ChIP Certified Antibodies?

SNAP-CUTANA™ Spike-in Controls

Defined controls for reliable CUT&RUN and CUT&Tag assays. Panel available for histone lysine methylation PTMs.

SNAP-Certified CUT&RUN Antibodies

Highly specific and efficient PTM antibodies validated in CUT&RUN workflows using SNAP-CUTANA Spike-in Controls.

SNAP-ChIP® Certified Antibodies

ChIP antibodies validated using SNAP-ChIP Spike-ins. Display best-in-class specificity and target enrichment.