<div class="snap-chik-content"> <p> Chromatin remodeling has been implicated in diverse diseases, including most types of cancer. The study of chromatin remodeling requires highly defined nucleosomal substrates, which are challenging to produce and adapt to various assays. The EpiDyne® platform addresses this unmet need, leveraging EpiCypher dNucs™ as substrates for a variety of nucleosome remodeling assays. </p> <div class="custom-btns-block"> <a href="https://www.epicypher.com/epidyne-chromatin-remodeling-substrates/#epidynenucs" class="button snap-chip-custom-btn">Shop EpiDyne Substrates</a> </div> <p></p> <h5> EpiDyne substrates are available for three assay readouts</h5> <ul> <li>FRET <a href="/content/documents/technotes/EpiDyne_FRET.pdf/">(read Tech Note here)</a> – HTS compatible</li> <li>Radiometric DAM methyltransferase assays – HTS compatible</li> <li>Restriction enzyme accessibility <a href="/content/documents/technotes/EpiDyne_REA.pdf/">(read Tech Note here)</a></li> </ul> <h5>Learn more:</h5> <ul> <li><a href="/content/documents/brochures/EpiDyne.pdf/"> EpiDyne Brochure</a></li> <li>Getting started with EpiDyne? <a href="/content/documents/technotes/EpiDyne_FRET.pdf/">Read our Tech Note!</a></li> <li>Learn about EpiDyne applications on <a href=" /blog/epidyne-exploring-chromatin-remodeling-substrates-with-nucleosomes/">our Blog</a></li> </ul> <h5> Shop related products and services:</h5> <ul class="category-nav-list"> <li><a href="/epidyne-chromatin-remodeling-enzymes/">EpiDyne Remodeling Enzymes</a></li> <li><a href="/epidyne-chromatin-remodeling-hts-assays/">EpiDyne HTS Services</a></li> </ul> <a name="epidynenucs"></a>

EpiDyne-FRET Nucleosome Remodeling Assay Substrate
SKU: 16-4201
EpiDyne-FRET Nucleosome Remodeling Assay Substrate Description: Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A-Cy5, H2B, H3.2 and H4; accession numbers: H2A-P04908; H2B-O60814;...
$575.00
EpiDyne Nucleosome Remodeling Assay Substrate ST601-GATC1
SKU: 16-4101
EpiDyne Nucleosome Remodeling Assay Substrate ST601-GATC1 Description: Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4. Accession numbers: H2A-P04908;...
$525.00
EpiDyne Remodeling Assay Substrate DNA ST601-GATC0
SKU: 18-4100
EpiDyne Remodeling Assay Substrate DNA ST601-GATC0 Description: EpiDyne Remodeling Assay Substrate DNA ST601-GATC0 is a 217 base-pair double-stranded DNA fragment. This sequence includes the Lowary 601 nucleosome positioning sequence (see...
$105.00
EpiDyne Remodeling Assay Substrate DNA ST601-GATC1
SKU: 18-4101
EpiDyne Remodeling Assay Substrate DNA ST601-GATC1 Description: EpiDyne Remodeling Assay Substrate DNA ST601-GATC1 is a 217 base-pair double-stranded DNA fragment. This sequence includes the Lowary 601 nucleosome positioning sequence (see...
$105.00