Chromatin remodeling regulates DNA access on chromatin and thus impacts gene expression and genome repair. Many ATP-dependent chromatin remodeling enzymes are associated with human disease but are challenging targets to study biochemically due to the requirement for nucleosome-based substrates. EpiCypher has addressed this need by developing EpiDyne, a family of recombinant nucleosome substrates to monitor chromatin remodeling activity in vitro.

Opening the door for the study of disease-relevant ATP-dependent chromatin remodeling complexes

Services capabilities
  • Assay development / optimization
  • Inhibitor profiling / specificity testing
  • HTS assay optimization / miniaturization
Multiple assay formats are available
  • FRET
  • Restriction Enzyme Accessibility
  • DAM methyltransferase

EpiDyne-FRET Nucleosome Remodeling Substrate application technical note LINK
EpiDyne Restriction Enzyme Assay Nucleosome Remodeling Substrate application technical note LINK Download the EpiDyne Nucleosome Remodeling Substrate brochure LINK

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