Histone post-translational modifications (PTMs) play crucial roles in chromatin regulation, interacting with a wide array of enzymes, reader proteins, and multi-subunit complexes to coordinate downstream processes. Historically, modified histone peptides have been the favored substrate for in vitro chromatin studies, under the assumption that PTMs are unaffected by higher order nucleosome structure. However, recent work from EpiCypher points to an integral role for nucleosome conformation in dictating histone PTM interactions and chromatin function (Marunde et al. 2022; Morgan et al. 2021).
The use of nucleosome substrates is essential to generate accurate, physiological data, and are highly recommended compared to histone peptides. EpiCypher offers a diverse array of recombinant nucleosomes carrying various histone PTMs, histone variants, oncogenic mutations, and more. We also offer custom nucleosome development services for the study of exotic PTMs or specialized research projects.
However, if you still require histone peptides to complete an ongoing course of research, you can access our peptides by referring to the list below and requesting a quote at firstname.lastname@example.org, referencing the Catalog Number.
All peptides are $145 for a 50 µg pack size.