Histone modifications and mutations play a central role in regulating nucleosome structure, chromatin accessibility, and gene expression, and are part of key pathways in development and disease. Histones with specific amino acid mutations have been identified as causal to many types of cancers. EpiCypher’s broad portfolio of highly pure, biochemically defined nucleosomes empowers researchers to dissect epigenetic regulation in applications such as drug development, target validation, and biomarker discovery.

Offerings include:

• Designer Nucleosomes (dNucs™) with site-specific histone post-translational modifications (PTMs), including lysine methylation and acetylation, phosphorylation, and ubiquitination
• EpiDyne^™ Chromatin Remodeling Substrates, designed for monitoring nucleosome remodeling enzyme activity
• Variant Nucleosomes (vNucs) assembled with histone variants
• Oncogenic Nucleosomes (oncoNucs) bearing cancer-associated histone mutations
• Acidic Patch Mutant Nucleosomes with defined mutations in the H2A/H2B acidic patch
• SNAP Spike-in Controls, designed specifically for CUT&RUN, CUT&Tag, and ChIP-seq experiments

Why do nucleosomes outperform histone peptides in functional assays? Read this blog post.

For questions, pricing, or custom nucleosome development inquiries, Contact Us or Request a Quote.