Webinar recap: Nucleosomes define the histone code
At the center of chromatin regulatory mechanisms is the nucleosome – a histone octamer wound by DNA. The tails of […]
Nucleosome
Deciphering the Histone Code with the dCypherâ„¢ Platform
Many nuclear processes are coordinated by the activity of chromatin associated proteins (CAPs) which add, remove, and recognize specific histone
The Nucleosome Acidic Patch: A Master Landing Dock for Chromatin Regulators
The nucleosome is the repeating unit of chromatin and serves as the physiological substrate for diverse chromatin interacting proteins, including
Defined Spike-in Controls and a Validated Workflow for our New CUT&RUN Kits
CUT&RUN is quickly becoming a leading assay for chromatin profiling, and it’s easy to see why. The targeted cleavage of
Histone Citrullination, NETs and NETosis : Linking Chromatin to Inflammatory Responses and Disease
Citrullination of histone tails (histones H3, H4 and H2A) is a widely studied nucleosome post-translational modification (PTM) in immunology research,
Learn More About EpiCypher’s Custom Nucleosome Assembly Services!
Chromatin is one of the most rapidly growing fields of biomedical research, with potential applications in diagnostics, prognostics, and therapeutics.
Finding the Best Substrate for Studying Histone Modifications
Chromatin and its regulation are indicated in a wide variety of human diseases, including cancer, and together comprise a rapidly
Antibodies, ChIP-seq, Nucleosome
Histone Peptides vs. Nucleosomes : Which is better for ChIP antibody validation?
Highly specific antibodies are a crucial component of epigenetics research, and form the foundation of multiple chromatin profiling assays. For
Chromatin Remodeling Assays, Nucleosome
EpiDyne®: Exploring Chromatin Remodeling Substrates with Nucleosomes
Nucleosomes are the fundamental repeating units of chromatin, comprised of a histone octamer wrapped by ~147bp DNA. A common focus
Nucleosome, Target Discovery & Screening Assays
Peptide or Nucleosome? dCypherâ„¢ Reveals the Optimal Substrate for Histone PTM Analyses
Histone ‘reader’ proteins contain evolutionarily conserved domains that bind to specific histone post-translational modifications (PTMs)1. These proteins have been shown to regulate