Learn More About EpiCypher’s Custom Nucleosome Assembly Services!
Chromatin is one of the most rapidly growing fields of biomedical research, with potential applications in diagnostics, prognostics, and therapeutics. […]
Finding the Best Substrate for Studying Histone Modifications
Chromatin and its regulation are indicated in a wide variety of human diseases, including cancer, and together comprise a rapidly
Choosing the Right ChIP Antibody for Your Experiment
There are multiple components to designing and executing a successful chromatin immunoprecipitation (ChIP) or ChIP-seq experiment: – What target should
CUT&RUN
EpiCypher’s Optimized CUTANA™ CUT&RUN Protocol for Transcription Factors, Histone PTMs, and More!
Immunotethering approaches, such as those used in CUT&RUN (Cleavage Under Targets & Release Using Nuclease) assays, are one of the most exciting
Antibodies, ChIP-seq, Nucleosome
Histone Peptides vs. Nucleosomes : Which is better for ChIP antibody validation?
Highly specific antibodies are a crucial component of epigenetics research, and form the foundation of multiple chromatin profiling assays. For
Chromatin Remodeling Assays, Nucleosome
EpiDyne®: Exploring Chromatin Remodeling Substrates with Nucleosomes
Nucleosomes are the fundamental repeating units of chromatin, comprised of a histone octamer wrapped by ~147bp DNA. A common focus
Nucleosome, Target Discovery & Screening Assays
Peptide or Nucleosome? dCypher™ Reveals the Optimal Substrate for Histone PTM Analyses
Histone ‘reader’ proteins contain evolutionarily conserved domains that bind to specific histone post-translational modifications (PTMs)1. These proteins have been shown to regulate