ATP-dependent chromatin remodeling enzymes are frequently mutated in cancer and represent emerging targets for therapeutic development. The EpiDyne™ platform enables precise, quantitative interrogation of nucleosome remodeling activity using EpiCypher’s highly pure recombinant nucleosomes as defined substrates.

To support diverse assay needs, EpiCypher offers recombinant chromatin remodeling enzymes—including SMARCA2 and SMARCA4 (the ATPase subunits of the SWI/SNF complex) and the ACF complex (ISWI-type), paired with multiple assay formats:

• EpiDyne-FRET: Fluorescence-based, high-throughput screening (HTS) compatible
• EpiDyne-PicoGreen: Low-cost, scalable alternative with high-throughput potential
• EpiDyne-REA: Restriction enzyme accessibility assays for mechanistic studies

See full enzyme descriptions and applications in the User Guide.

EpiDyne Chromatin Remodeling Assay Services are available! Contact Us or Request a Quote for more information.