NCOA3/SRC3 CUTANA™ CUT&RUN Antibody

This antibody meets EpiCypher’s “CUTANA Compatible” criteria for performance in Cleavage Under Targets and Release Using Nuclease (CUT&RUN) and/or Cleavage Under Targets and Tagmentation (CUT&Tag) approaches to genomic mapping. Every lot of a CUTANA Compatible antibody is tested in the indicated CUTANA approach using EpiCypher optimized protocols and determined to yield peaks that show a genomic distribution pattern consistent with reported function(s) of the target protein. Consistent with its role as a nuclear receptor coactivator that facilitates ER-mediated transcription (1), NCOA3 (SRC3) antibody shows CUT&RUN peaks in response to estradiol stimulation (Figure 1) that overlap with known estrogen response element (ERE) binding motifs (Figure 2). SRC3 CUT&RUN peaks also overlap with ER alpha antibodies (N- and C-term; 13-2011 and 13-2012 respectively) (Figure 2).