CUTANA™ ATAC-seq Services
Your partner for reliable chromatin accessibility profiling
ATAC-seq (Assay for Transposase-Accessible Chromatin using sequencing) marks open chromatin, the regions where gene regulatory proteins bind, by using the Tn5 transposase to simultaneously cut accessible DNA and insert sequencing adapters in a single step. Closed, nucleosome-wrapped chromatin stays untagmented, so the resulting signal maps enhancers, promoters, and transcription factor footprints genome-wide.
As the team that built CUTANA™ CUT&RUN, CUT&Tag, and Fiber-seq, EpiCypher applies that same chromatin expertise to ATAC-seq. Our CUTANA™ ATAC-seq Services give pharma, biotech, and academic researchers full-service access to a validated, competitor-benchmarked workflow, from sample to sequence data reports, without having to build accessibility profiling capability in-house.
Send us your samples and receive analysis-ready chromatin accessibility data. We can handle everything from sample QC through downstream analysis, with expanded analysis options available, built on the same validated chemistry as our CUTANA™ ATAC-seq Kit.
Ready to Get Started?
Tell us briefly about your project, and a member of our Services team will get back to you shortly!
As Our Partner, You Can Expect:
Confidence Before You Commit
Talk through your experimental design with our chromatin mapping experts before you send a single sample.
Broad Sample Compatibility
We accept cryopreserved cells, isolated nuclei, and intact flash-frozen tissue.
Your Project, Fully Managed
Sample QC, nuclei isolation, ATAC-seq library prep, sequencing, and bioinformatics are all handled by our team.
Validated Chemistry and Workflow
Built on the same chemistry and protocol used in our CUTANA™ ATAC-seq Kit, compatible with low sample inputs.
Personalized Data Review
Every project concludes with a one-on-one review of your full QC results, delivered as a conversation with our experts.
Multiomics Under One Roof
Add CUT&RUN and/or Fiber-seq to the same project and leave with a complete multiomic profile of your samples.
Robust ATAC-seq Results From as Few as 1,000 Nuclei
CUTANA™ ATAC-seq generates reproducible chromatin accessibility profiles down to 1,000 K562 cells. (A) Representative IGV tracks show 3 loci spanning a range of RNA expression levels. (B) Transcription start site (TSS) enrichment plots for 50k, 10k, and 1k nuclei inputs. Heatmap rows are sorted by signal intensity in the 50k nuclei sample and held constant across panels for direct comparison.
FAQs About Our ATAC-seq Services
How does a project work?
Four steps: (1) a design consult with our chromatin experts; (2) sample QC on receipt; (3) nuclei extraction, library prep, and sequencing in-house; (4) a one-on-one personalized data delivery to review your results
What sample types can I submit for ATAC-seq Services?
We accept cryopreserved cells, isolated nuclei, and flash-frozen tissue across a wide range of cell and tissue types. We review your specific sample type during the design consult and confirm the right handling before you ship. If your material needs upstream dissociation or nuclei extraction, our team can take that on. Not sure whether your samples will work? Ask us by filling out the form below.
Does EpiCypher accept tissue samples for ATAC-seq Services?
Yes! We accept flash-frozen tissue samples for ATAC-seq Services. Our team can dissociate tissue and extract nuclei for your ATAC-seq Services project.
How much material do I need for ATAC-seq Services?
Minimum material needed depends on your sample type. For cryopreserved cells or nuclei, target 200,000 per sample. For flash-frozen tissue, 5-10 mg per sample should be sufficient for tissues with high cellularity. If you have any questions on whether your amount of material is sufficient for ATAC-Seq Services, contact us to discuss your project with our experts. ATAC-seq is compatible with low inputs, and we can often adjust the standard workflow to accommodate limited or precious samples.
What data do I receive?
Every project returns a complete, analysis-ready data package:
- Raw sequencing reads (FASTQ)
- Aligned reads (BAM + index)
- Peak calls (narrowPeak and bigWig)
- An assay QC report (HTML/PDF) covering TSS enrichment, FRiP, fragment-size distribution, duplication rate, and mitochondrial read percentage
Every project also ends with a one-on-one review of your results with the scientists who ran your samples.
Need more than primary analysis? Ask about our advanced bioinformatics: differential enrichment, motif analysis, GO-term enrichment, TSS and peak heatmaps, consensus peaks, and more.
Does EpiCypher offer any genomics services other than ATAC-seq?
What other insights does Fiber-seq provide?
Fiber-seq resolves accessibility, transcription-factor footprints, and DNA methylation on single DNA molecules, revealing heterogeneity that population methods average out. If your ATAC-seq results raise questions a single-molecule view could answer, we can run Fiber-seq on the same samples. See CUTANA™ Fiber-seq Services.
