dCypher is a new epigenetics discovery service that combines the diversity of histone peptide array technology with the high sensitivity of AlphaScreen® to identify novel chromatin interactions.

With your choice of either nucleosome or peptide substrates, you have the option of hundreds of interrogating post-translational modifications or combinations of modifications.

dCypher binding assays identify hits that would be missed by peptide arrays

Applications
  • Reader binding domain interaction discovery
  • Drug target identification and validation
  • Binding domain inhibitor screening
dCypher advantages over current technologies
  • Unmatched sensitivity vs. peptide pulldown
  • Requires substantially less material than peptide arrays for reader domain interrogation
  • Over 80 unique modified nucleosome substrates
  • Nearly 300 modified histone peptides (single and combinatorial PTMs)
  • Liquid phase reaction results in optimized binding and detection

WHAT DOES YOUR DOMAIN BIND TO?
Let dCypher tell you!

dCypher BROCHURE LINK
Complete list of dCypher peptides LINK
Complete list of recombinant nucleosomes LINK

SCIENTIFIC POSTER

dCypher: A High-Throughput Service for Chromatin Interaction Discovery LINK