EpiCypher Launches SNAP-ChIP Product Family: Now Enabling Normalized Chromatin IP Experiments

Research Triangle Park, NC – 22 September 2017 – EpiCypher, Inc. has released SNAP-ChIP (Sample Normalization and Antibody Profiling for Chromatin Immunoprecipitation), a breakthrough product family that will dramatically improve researchers’ ability to normalize ChIP experiments. SNAP-ChIP utilizes EpiCypher’s proprietary DNA barcoded recombinant designer nucleosomes (dNucs) as next-generation spike-ins for ChIP. With SNAP-ChIP, researchers now have the ability to both normalize samples across experiments (enabling broad collaboration throughout the scientific community, an the generate detailed data pertaining to antibody specificity and cross-reactivity.

The first offering in the SNAP-ChIP family, the SNAP-ChIP K-MetStat panel (lysine-methylation status panel), is comprised of 16 uniquely modified dNucs carrying disease-relevant lysine methylation modifications on histones H3 and H4. Each modification site in this pool (H3K4, H3K9, H3K27, H3K36, H4K20) is represented by all lysine methylation states (i.e. me0, me1, me2, and me3). “For the first time, scientists can both monitor technical variability and measure antibody specificity in the same experiment. This has not been possible with any other spike-in product or approach currently available,” states EpiCypher’s Chief Scientific Officer, Michael Keogh, PhD. Keogh further adds “The beauty of the SNAP-ChIP product line is that it fits seamlessly into existing ChIP workflows, allowing the epigenetics community immediate access to this breakthrough. In fact, we have already contracted with a number of antibody development companies to use our SNAP-ChIP K-MetStat Panel to directly analyze the specificity of antibodies in their portfolios in a ChIP setting.”

Numerous additional modification-specific SNAP-ChIP dNuc panels are currently in development (e.g. arginine methylation, lysine acylation, etc.) and are slated for release in early 2018.

About EpiCypher – A pioneer in the field of epigenetics and chromatin biology, EpiCypher is a bioscience company developing transformative technologies and delivering superior products to researchers worldwide. EpiCypher manufactures and sells recombinant “designer” modified nucleosomes (dNucs), including the EpiDyne™ family of substrates for nucleosome remodeling assays, as well as recombinant histone binding proteins, peptides and antibodies, and offers a broad range of custom substrate manufacturing and assay development services.

For more information about SNAP-ChIP, visit EpiCypher.com/products/nucleosomes/snap-chip-spike-ins For more information about EpiCypher, visit EpiCypher.com

Media Contact: Leslie Lewis, EpiCypher, Inc. [email protected]