Mutant Nucleosomes
Histone mutations cause distinct changes in nucleosome structure, chromatin accessibility and gene expression, and are linked to numerous disease states. This research has also revealed the importance of considering the entire nucleosome structure in chromatin interactions, as several of these mutations occur within the nucleosome core and modulate PTM crosstalk and multivalent binding mechanisms. EpiCypher offers a unique collection of Mutant Nucleosomes (Mutant Nucs) providing defined substrates for binding assays, drug research, and more.
Buy any 3 full size Mutant Nucleosomes at full price, get 1 free.
Use promo code 4FOR3.
Substrate Types and Applications
- Oncogenic Nucleosomes (e.g. H3.3K27M, H3.3G34R)
- Acidic Patch Mutant Nucleosomes (e.g. H2AE61A, H2AE92K)
- Study impact of mutant histones on protein binding / enzymatic function
Learn more:
- Recombinant Nucleosomes Brochure: Overview of all our nucleosome products
- Acidic Patch Blog: All you need to know about the nucleosome acidic patch
- How do we quantify our nucleosomes? See our Nucleosome Quantification Method
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Please email us at [email protected] for additional information and pricing or complete a Request for Quote form on our website.
All nucleosomes are available non-biotinylated upon request.
Read more about how we quantify our nucleosomes.