Mutant Nucleosomes

Histone mutations cause distinct changes in nucleosome structure, chromatin accessibility and gene expression, and are linked to numerous disease states. This research has also revealed the importance of considering the entire nucleosome structure in chromatin interactions, as several of these mutations occur within the nucleosome core and modulate PTM crosstalk and multivalent binding mechanisms. EpiCypher offers a unique collection of Mutant Nucleosomes (Mutant Nucs) providing defined substrates for binding assays, drug research, and more.
Buy any 3 full size Mutant Nucleosomes at full price, get 1 free.

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Substrate Types and Applications
  • Oncogenic Nucleosomes (e.g. H3.3K27M, H3.3G34R)
  • Acidic Patch Mutant Nucleosomes (e.g. H2AE61A, H2AE92K)
  • Study impact of mutant histones on protein binding / enzymatic function
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