Nucleosome, Recombinant Human, H2AXS139phos dNuc, Biotinylated

Recombinant mononucleosomes (H2AXS139phos) consist of 147 base pairs of DNA wrapped around an octamer core of histone proteins (two each of H2AX, H2B, H3.1 and H4) to form a nucleosome, the basic repeating unit of chromatin. The 147 bp 601 sequence, identified by Lowary and Widom [1], has high affinity for histone octamers and is useful for nucleosome assembly. H2AXS139phos dNuc contains phosphorylated-serine at position 139 on histone H2AX. The DNA in this nucleosome contains a 5’ biotin-TEG group.