Histone H2AZ.2, Recombinant Human

Recombinant human histone H2AZ.2 (H2A.V; H2AF.V; Q71UI9) expressed in E. coli and purified by FPLC. Histone variants H2AZ.1 (H2A.Z; H2AFZ; P0C0S5) and H2AZ.2 differ by three amino acids and are incorporated into a subset of nucleosomes in place of canonical histone H2A. H2AZ is implicated in diverse functions ranging from transcriptional regulation, chromosome transmission and DNA damage repair. H2AZ has a dedicated deposition machinery (the SWR-C ATPase) and is acetylated by the KAT4/TIP60 complex.