Chromodomain Proteins

Chromodomains recognize methylated lysine residues on histone proteins. Although methyl-lysine PTMs have various functions, chromodomains typically bind to repressive PTMs (H3K27me3, H3K9me3), and act to recruit protein complexes and / or modifying enzymes to regions of heterochromatin. EpiCypher® offers a suite of GST-tagged recombinant chromodomains, useful for determining substrate recognition and for use in methyl-lysine binding experiments.

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