Histone Citrullination (H3Cit) Assays

Histone citrullination (H3Cit) occurs in neutrophils during inflammatory responses, and is an essential component of Neutrophil Extracellular Traps, or NETs. NETs are a defining feature of a unique mode of cell death termed “NETosis,” and have been linked to a wide range of human pathologies, including autoimmune diseases and cancer. EpiCypher H3Cit Assays provide reliable, quantitative detection of this PTM to improve our understanding of NETs in biology and disease.

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Highly sensitive H3Cit assays for NETosis research

Highly specific H3Cit antibody (Catalog No. 13-0046) validated against recombinant nucleosomes
Reliable assay calibration curve generated using recombinant nucleosomes, replicating the endogenous chromatin target
Nucleosome-based calibration allows accurate quantification and lot-to-lot reproducibility, not possible with modified histone peptides
See the advantages of nucleosome-based quantification and antibody profiling for H3Cit in EpiCypher's new study.

H3R8Cit ELISA Capture Kit

SKU: R&D143001

H3R8Cit ELISA Capture Kit Description: Protein arginine deiminase 4 (PAD4)-mediated citrullination of histone tail residues is a known marker of neutrophil extracellular trap (NET) formation and “NETosis” mediated cell death. NETs consist of...

$295.00

Histone H3R8Cit Antibody

SKU: 13-0046

This antibody is sold as part of H3R8Cit ELISA Capture Kit, EpiCypher Catalog No. R&D143001.

$0.00

Nucleosome, Recombinant Human, H3 Cit2,8,17 dNuc

SKU: 16-1362

Nucleosome, Recombinant Human, H3 Cit2,8,17 dNuc Description: Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P04908; H2B-O60814; H3.1-P68431; H4-P62805)...

$575.00

Nucleosome, Recombinant Human, H3 Cit2,8,17 dNuc Biotinylated

SKU: 16-0362

Nucleosome, Recombinant Human, H3 Cit2,8,17 dNuc Biotinylated Description: Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P04908; H2B-O60814; H3...

$575.00

H3R8Cit ELISA Capture Kit

Histone H3R8Cit Antibody

Nucleosome, Recombinant Human, H3 Cit2,8,17 dNuc

Nucleosome, Recombinant Human, H3 Cit2,8,17 dNuc Biotinylated

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