Nucleosomes are the in vivo targets of chromatin regulating proteins (i.e. readers, writers, and erasers), making them ideal biochemical substrates for drug development over peptides, providing access to historically challenging targets. EpiCypher offers a custom nucleosome development service of fully defined and homogeneous recombinant nucleosomes incorporating different DNA and histone modifications, site mutations, or histone variants.
Build your own nucleosome for Drug Development and Chromatin Biology Research
- Assay development / optimization
- HTS assay optimization / miniaturization
- Any DNA and histone modifications, site mutations and histone variants