SNAP-ChIP® Spike-In Controls are Essential for ChIP Experiments
Despite the overwhelming popularity of chromatin immunoprecipitation (ChIP) in epigenetics research, ChIP methods have poor yields, high background, and low accuracy / r…
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EpiDyne®: Exploring Chromatin Remodeling Substrates with Nucleosomes
Nucleosomes are the fundamental repeating units of chromatin, comprised of a histone octamer wrapped by ~147bp DNA. A common focus of epigenetics research is the additio…
Peptide or Nucleosome? dCypher ™ Reveals the Optimal Substrate for Histone PTM Analyses
Histone ‘reader’ proteins contain evolutionarily conserved domains that bind to specific histone post-translational modifications (PTMs)1. These proteins h…
Why are designer nucleosomes so important for epigenetics research?
Nucleosome substrates are emerging tools for the in vitro study of chromatin epigenetic regulation, with applications from basic chromatin biology research to high-throughput drug screening…