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Chromatin structure and its chemical modifications regulate the ubiquitin ligase substrate selectivity of UHRF1. Robert M. Vaughan, Bradley M. Dickson, Matthew F. Whelihan, Andrea L. Johnstone, Evan M. Cornett, Marcus A. Cheek, Christine A. Ausherman, Martis W. Cowles, Zu-Wen Sun, Scott B. Rothbart. Aug 2018. PNAS

ABSTRACT: DNA methylation and histone posttranslational modifications are key epigenetic marks that contribute to the fine-tuned regulation of gene expression and other chromatin-templated biological processes. Here, we build artificial chromatin templates and reveal key chromatin structural features and epigenetic marks that coordinately regulate the binding and enzymatic activity of the DNA methylation regulator UHRF1. Studying activities of epigenetic regulators in the context of defined chromatin templates, particularly for multidomain histone and DNA binding proteins such as UHRF1, is critical for understanding molecular mechanisms of epigenetic crosstalk and mechanics regulating epigenetic signaling, and for determining how epigenetic dysregulation contributes to human disease.

Scientific Publications from our Founders and Employees


Developing Spindlin1 small-molecule inhibitors by using protein microarrays. Bae N, M Viviano, X Su, J Lv, D Cheng, C Sagum, S Castellano, X Bai, C Johnson, MI Khalil, J Shen, K Chen, H Li, G Sbardella and MT Bedford. 2017. Nat Chem Biol

PRMT5 C-terminal Phosphorylation Modulates a 14-3-3/PDZ Interaction Switch. Espejo AB, G Gao, K Black, S Gayatri, N Veland, J Kim, T Chen, M Sudol, C Walker and MT Bedford. 2017. J Biol Chem 292: 2255-2265.

PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1. Gao G, S Dhar and MT Bedford. 2017. Nucleic Acids Res 45: 4359-4369.

Expanding the Reader Landscape of Histone Acylation. Khan A, JB Bridgers and BD Strahl. 2017. Structure 25: 571-573.

Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. Liang J, CA Sagum, MT Bedford, SS Sidhu, M Sudol, Z Han and RN Harty. 2017. PLoS Pathog 13: e1006132.

Shaping the cellular landscape with Set2/SETD2 methylation. McDaniel SL and BD Strahl. 2017. Cell Mol Life Sci

Histone gene replacement reveals a post-transcriptional role for H3K36 in maintaining metazoan transcriptome fidelity. Meers MP, T Henriques, CA Lavender, DJ McKay, BD Strahl, RJ Duronio, K Adelman and AG Matera. 2017. Elife 6:

Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions. Shanle EK, SA Shinsky, JB Bridgers, N Bae, C Sagum, K Krajewski, SB Rothbart, MT Bedford and BD Strahl. 2017. Epigenetics Chromatin 10: 12.

Cancer epigenetics: Reading the future of leukaemia. Wilkinson AW and O Gozani. 2017. Nature 543: 186-188.


Regulation of Methyllysine Readers through Phosphorylation. Andrews FH, J Gatchalian, K Krajewski, BD Strahl and TG Kutateladze. 2016. ACS Chem Biol 11: 547-553.

The essential role of acetyllysine binding by the YEATS domain in transcriptional regulation. Andrews FH, EK Shanle, BD Strahl and TG Kutateladze. 2016. Transcription 7: 14-20.

The Taf14 YEATS domain is a reader of histone crotonylation. Andrews FH, SA Shinsky, EK Shanle, JB Bridgers, A Gest, IK Tsun, K Krajewski, X Shi, BD Strahl and TG Kutateladze. 2016. Nat Chem Biol 12: 396-398.

Insights into newly discovered marks and readers of epigenetic information. Andrews FH, BD Strahl and TG Kutateladze. 2016. Nat Chem Biol 12: 662-668.

Multivalent Chromatin Engagement and Inter-domain Crosstalk Regulate MORC3 ATPase. Andrews FH, Q Tong, KD Sullivan, EM Cornett, Y Zhang, M Ali, J Ahn, A Pandey, AH Guo, BD Strahl, JC Costello, JM Espinosa, SB Rothbart and TG Kutateladze. 2016. Cell Rep 16: 3195-3207.

Epigenetic regulation of the histone-to-protamine transition during spermiogenesis. Bao J and MT Bedford. 2016. Reproduction 151: R55-70.

Regulation of receptor-type protein tyrosine phosphatases by their C-terminal tail domains. Barnea M, T Olender, MT Bedford and A Elson. 2016. Biochem Soc Trans 44: 1295-1303.

Quantitative Analysis of Dynamic Protein Interactions during Transcription Reveals a Role for Casein Kinase II in Polymerase-associated Factor (PAF) Complex Phosphorylation and Regulation of Histone H2B Monoubiquitylation. Bedard LG, R Dronamraju, JL Kerschner, GO Hunter, ED Axley, AK Boyd, BD Strahl and AL Mosley. 2016. J Biol Chem 291: 13410-13420.

Nonhistone Lysine Methylation in the Regulation of Cancer Pathways. Carlson SM and O Gozani. 2016. Cold Spring Harb Perspect Med 6:

Potent and Selective Peptide-based Inhibition of the G Protein Galphaq. Charpentier TH, GL Waldo, EG Lowery-Gionta, K Krajewski, BD Strahl, TL Kash, TK Harden and J Sondek. 2016. J Biol Chem 291: 25608-25616.

Histone H3 and TORC1 prevent organelle dysfunction and cell death by promoting nuclear retention of HMGB proteins. Chen H, JJ Workman, BD Strahl and RN Laribee. 2016. Epigenetics Chromatin 9: 34.

Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray. Cornett EM, BM Dickson, RM Vaughan, S Krishnan, RC Trievel, BD Strahl and SB Rothbart. 2016. Methods Enzymol 574: 31-52.

PRMT5 C-terminal Phosphorylation Modulates a 14-3-3/PDZ Interaction Switch. Espejo AB, G Gao, K Black, S Gayatri, N Veland, J Kim, T Chen, M Sudol, C Walker and MT Bedford. 2017. J Biol Chem 292: 2255-2265.

Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Esteve PO, G Zhang, VK Ponnaluri, K Deepti, HG Chin, N Dai, C Sagum, K Black, IR Correa, Jr., MT Bedford, X Cheng and S Pradhan. 2016. Nucleic Acids Res 44: 1642-1656.

Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive. Gatchalian J, CM Gallardo, SA Shinsky, RR Ospina, AM Liendo, K Krajewski, BJ Klein, FH Andrews, BD Strahl, MvW KH and TG Kutateladze. 2016. Nucleic Acids Res 44: 6102-6112.

Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs. Gayatri S, MW Cowles, V Vemulapalli, D Cheng, ZW Sun and MT Bedford. 2016. Sci Rep 6: 28718.

Structure/Function Analysis of Recurrent Mutations in SETD2 Protein Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and Histone H3 Lys-36 Trimethylation. Hacker KE, CC Fahey, SA Shinsky, YJ Chiang, JV DiFiore, DK Jha, AH Vo, JA Shavit, IJ Davis, BD Strahl and WK Rathmell. 2016. J Biol Chem 291: 21283-21295.

ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding. Han Z, CA Sagum, MT Bedford, SS Sidhu, M Sudol and RN Harty. 2016. J Virol 90: 9163-9171.

Hemi-methylated DNA regulates DNA methylation inheritance through allosteric activation of H3 ubiquitylation by UHRF1. Harrison JS, EM Cornett, D Goldfarb, PA DaRosa, ZM Li, F Yan, BM Dickson, AH Guo, DV Cantu, L Kaustov, PJ Brown, CH Arrowsmith, DA Erie, MB Major, RE Klevit, K Krajewski, B Kuhlman, BD Strahl and SB Rothbart. 2016. Elife 5:

Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation. Hattori T, D Lai, IS Dementieva, SP Montano, K Kurosawa, Y Zheng, LR Akin, KM Swist-Rosowska, AT Grzybowski, A Koide, K Krajewski, BD Strahl, NL Kelleher, AJ Ruthenburg and S Koide. 2016. Proc Natl Acad Sci U S A 113: 2092-2097.

TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Hossain MB, R Shifat, DG Johnson, MT Bedford, KR Gabrusiewicz, N Cortes-Santiago, X Luo, Z Lu, R Ezhilarasan, EP Sulman, H Jiang, SS Li, FF Lang, J Tyler, MC Hung, J Fueyo and C Gomez-Manzano. 2016. Sci Adv 2: e1501290.

Molecular and Neural Functions of Rai1, the Causal Gene for Smith-Magenis Syndrome. Huang WH, CJ Guenthner, J Xu, T Nguyen, LA Schwarz, AW Wilkinson, O Gozani, HY Chang, M Shamloo and L Luo. 2016. Neuron 92: 392-406.

Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette. Li S, Z Yang, X Du, R Liu, AW Wilkinson, O Gozani, SE Jacobsen, DJ Patel and J Du. 2016. Structure 24: 486-494.

Combinatorial Histone Readout by the Dual Plant Homeodomain (PHD) Fingers of Rco1 Mediates Rpd3S Chromatin Recruitment and the Maintenance of Transcriptional Fidelity. McDaniel SL, JE Fligor, C Ruan, H Cui, JB Bridgers, JV DiFiore, AH Guo, B Li and BD Strahl. 2016. J Biol Chem 291: 14796-14802.

Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation. Metzger E, D Willmann, J McMillan, I Forne, P Metzger, S Gerhardt, K Petroll, A von Maessenhausen, S Urban, AK Schott, A Espejo, A Eberlin, D Wohlwend, KM Schule, M Schleicher, S Perner, MT Bedford, M Jung, J Dengjel, R Flaig, A Imhof, O Einsle and R Schule. 2016. Nat Struct Mol Biol 23: 132-139.

Systematic Analysis of Known and Candidate Lysine Demethylases in the Regulation of Myoblast Differentiation. Munehira Y, Z Yang and O Gozani. 2016. J Mol Biol

PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud. Norrie JL, Q Li, S Co, BL Huang, D Ding, JC Uy, Z Ji, S Mackem, MT Bedford, A Galli, H Ji and SA Vokes. 2016. Development 143: 4608-4619.

Dual Chromatin and Cytoskeletal Remodeling by SETD2. Park IY, RT Powell, DN Tripathi, R Dere, TH Ho, TL Blasius, YC Chiang, IJ Davis, CC Fahey, KE Hacker, KJ Verhey, MT Bedford, E Jonasch, WK Rathmell and CL Walker. 2016. Cell 166: 950-962.

Direct interrogation of the role of H3K9 in metazoan heterochromatin function. Penke TJ, DJ McKay, BD Strahl, AG Matera and RJ Duronio. 2016. Genes Dev 30: 1866-1880.

Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer. Reynoird N, PK Mazur, T Stellfeld, NM Flores, SM Lofgren, SM Carlson, E Brambilla, P Hainaut, EB Kaznowska, CH Arrowsmith, P Khatri, C Stresemann, O Gozani and J Sage. 2016. Genes Dev 30: 772-785.

A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin. Sankaran SM, AW Wilkinson, JE Elias and O Gozani. 2016. J Biol Chem 291: 8465-8474.

Multivalent Histone and DNA Engagement by a PHD/BRD/PWWP Triple Reader Cassette Recruits ZMYND8 to K14ac-Rich Chromatin. Savitsky P, T Krojer, T Fujisawa, JP Lambert, S Picaud, CY Wang, EK Shanle, K Krajewski, H Friedrichsen, A Kanapin, C Goding, M Schapira, A Samsonova, BD Strahl, AC Gingras and P Filippakopoulos. 2016. Cell Rep 17: 2724-2737.

A course-based undergraduate research experience investigating p300 bromodomain mutations. Shanle EK, IK Tsun and BD Strahl. 2016. Biochem Mol Biol Educ 44: 68-74.

Histone H3K36 methylation regulates pre-mRNA splicing in Saccharomyces cerevisiae. Sorenson MR, DK Jha, SA Ucles, DM Flood, BD Strahl, SW Stevens and TL Kress. 2016. RNA Biol 13: 412-426.

Regulation of transcriptional elongation in pluripotency and cell differentiation by the PHD-finger protein Phf5a. Strikoudis A, C Lazaris, T Trimarchi, AL Galvao Neto, Y Yang, P Ntziachristos, S Rothbart, S Buckley, I Dolgalev, M Stadtfeld, BD Strahl, BD Dynlacht, A Tsirigos and I Aifantis. 2016. Nat Cell Biol 18: 1127-1138.

A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Stuckey JI, BM Dickson, N Cheng, Y Liu, JL Norris, SH Cholensky, W Tempel, S Qin, KG Huber, C Sagum, K Black, F Li, XP Huang, BL Roth, BM Baughman, G Senisterra, SG Pattenden, M Vedadi, PJ Brown, MT Bedford, J Min, CH Arrowsmith, LI James and SV Frye. 2016. Nat Chem Biol 12: 180-187.

Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly. Tsai WC, S Gayatri, LC Reineke, G Sbardella, MT Bedford and RE Lloyd. 2016. J Biol Chem 291: 22671-22685.

Histone H4 Lysine 20 (H4K20) Methylation, Expanding the Signaling Potential of the Proteome One Methyl Moiety at a Time. van Nuland R and O Gozani. 2016. Mol Cell Proteomics 15: 755-764.

Light-induced nuclear export reveals rapid dynamics of epigenetic modifications. Yumerefendi H, AM Lerner, SP Zimmerman, K Hahn, JE Bear, BD Strahl and B Kuhlman. 2016. Nat Chem Biol 12: 399-401.

G9a-mediated methylation of ERalpha links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression. Zhang X, D Peng, Y Xi, C Yuan, CA Sagum, BJ Klein, K Tanaka, H Wen, TG Kutateladze, W Li, MT Bedford and X Shi. 2016. Nat Commun 7: 10810.

ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. Zhu L, Q Li, SH Wong, M Huang, BJ Klein, J Shen, L Ikenouye, M Onishi, D Schneidawind, C Buechele, L Hansen, J Duque-Afonso, F Zhu, GM Martin, O Gozani, R Majeti, TG Kutateladze and ML Cleary. 2016. Cancer Discov 6: 770-783.


Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes. Ali M, KD Daze, DE Strongin, SB Rothbart, H Rincon-Arano, HF Allen, J Li, BD Strahl, F Hof and TG Kutateladze. 2015. J Biol Chem 290: 22919-22930.

A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme. Carlson SM, KE Moore, SM Sankaran, N Reynoird, JE Elias and O Gozani. 2015. J Biol Chem 290: 12040-12047.

The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Chen S, Z Yang, AW Wilkinson, AJ Deshpande, S Sidoli, K Krajewski, BD Strahl, BA Garcia, SA Armstrong, DJ Patel and O Gozani. 2015. Mol Cell 60: 319-327.

Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation. Cliffe AR, JH Arbuckle, JL Vogel, MJ Geden, SB Rothbart, CL Cusack, BD Strahl, TM Kristie and M Deshmukh. 2015. Cell Host Microbe 18: 649-658.

Product binding enforces the genomic specificity of a yeast polycomb repressive complex. Dumesic PA, CM Homer, JJ Moresco, LR Pack, EK Shanle, SM Coyle, BD Strahl, DG Fujimori, JR Yates, 3rd and HD Madhani. 2015. Cell 160: 204-218.

Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Esteve PO, G Zhang, VK Ponnaluri, K Deepti, HG Chin, N Dai, C Sagum, K Black, IR Correa, Jr., MT Bedford, X Cheng and S Pradhan. 2015. Nucleic Acids Res

Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. Hadjikyriacou A, Y Yang, A Espejo, MT Bedford and SG Clarke. 2015. J Biol Chem 290: 16723-16743.

Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus. Hu SB, JF Xiang, X Li, Y Xu, W Xue, M Huang, CC Wong, CA Sagum, MT Bedford, L Yang, D Cheng and LL Chen. 2015. Genes Dev 29: 630-645.

Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex. Kapoor P, Y Bao, J Xiao, A Espejo, L Yang, MT Bedford, G Peng and X Shen. 2015. Mol Cell 58: 863-869.

Interrogating the function of metazoan histones using engineered gene clusters. McKay DJ, S Klusza, TJ Penke, MP Meers, KP Curry, SL McDaniel, PY Malek, SW Cooper, DC Tatomer, JD Lieb, BD Strahl, RJ Duronio and AG Matera. 2015. Dev Cell 32: 373-386.

Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene. Perez CJ, L Mecklenburg, J Jaubert, L Martinez-Santamaria, BM Iritani, A Espejo, E Napoli, G Song, M del Rio, J DiGiovanni, C Giulivi, MT Bedford, SY Dent, RD Wood, DF Kusewitt, JL Guenet, CJ Conti and F Benavides. 2015. J Invest Dermatol 135: 3133-3143.

Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. Perfetti MT, BM Baughman, BM Dickson, Y Mu, G Cui, P Mader, A Dong, JL Norris, SB Rothbart, BD Strahl, PJ Brown, WP Janzen, CH Arrowsmith, G Mer, KM McBride, LI James and SV Frye. 2015. ACS Chem Biol 10: 1072-1081.

An Interactive Database for the Assessment of Histone Antibody Specificity. Rothbart SB, BM Dickson, JR Raab, AT Grzybowski, K Krajewski, AH Guo, EK Shanle, SZ Josefowicz, SM Fuchs, CD Allis, TR Magnuson, AJ Ruthenburg and BD Strahl. 2015. Mol Cell 59: 502-511.

From histones to ribosomes: a chromatin regulator tangoes with translation. Rothbart SB, BM Dickson and BD Strahl. 2015. Cancer Discov 5: 228-230.

Coactivator-Associated Arginine Methyltransferase-1 Function in Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility. Sarker RS, G John-Schuster, A Bohla, K Mutze, G Burgstaller, MT Bedford, M Konigshoff, O Eickelberg and AO Yildirim. 2015. Am J Respir Cell Mol Biol 53: 769-781.

Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response. Shanle EK, FH Andrews, H Meriesh, SL McDaniel, R Dronamraju, JV DiFiore, D Jha, GG Wozniak, JB Bridgers, JL Kerschner, K Krajewski, GM Martin, AJ Morrison, TG Kutateladze and BD Strahl. 2015. Genes Dev 29: 1795-1800.

A course-based undergraduate research experience investigating p300 bromodomain mutations. Shanle EK, IK Tsun and BD Strahl. 2016. Biochem Mol Biol Educ 44: 68-74.

A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin. Simon JM, JS Parker, F Liu, SB Rothbart, S Ait-Si-Ali, BD Strahl, J Jin, IJ Davis, AL Mosley and SG Pattenden. 2015. J Biol Chem 290: 26088-26102.

Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1. Tong Q, G Cui, MV Botuyan, SB Rothbart, R Hayashi, CA Musselman, N Singh, E Appella, BD Strahl, G Mer and TG Kutateladze. 2015. Structure 23: 312-321.

An acetyl-methyl switch drives a conformational change in p53. Tong Q, SJ Mazur, H Rincon-Arano, SB Rothbart, DM Kuznetsov, G Cui, WH Liu, Y Gete, BJ Klein, L Jenkins, G Mer, AG Kutateladze, BD Strahl, M Groudine, E Appella and TG Kutateladze. 2015. Structure 23: 322-331.

H4K20 methylation: expanding the signaling potential of the proteome one methyl moiety at a time. van Nuland R and O Gozani. 2015. Mol Cell Proteomics

Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX. Wang L, L Xie, S Ramachandran, Y Lee, Z Yan, L Zhou, K Krajewski, F Liu, C Zhu, DJ Chen, BD Strahl, J Jin, NV Dokholyan and X Chen. 2015. Chem Biol 22: 849-861.

PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Yang Y, A Hadjikyriacou, Z Xia, S Gayatri, D Kim, C Zurita-Lopez, R Kelly, A Guo, W Li, SG Clarke and MT Bedford. 2015. Nat Commun 6: 6428.

A Meier-Gorlin syndrome mutation impairs the ORC1-nucleosome association. Zhang W, S Sankaran, O Gozani and J Song. 2015. ACS Chem Biol 10: 1176-1180.

An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Zhang ZM, SB Rothbart, DF Allison, Q Cai, JS Harrison, L Li, Y Wang, BD Strahl, GG Wang and J Song. 2015. Cell Rep 12: 1400-1406.


Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization. Emelyanov AV, J Rabbani, M Mehta, E Vershilova, MC Keogh and DV Fyodorov. 2014. Genes Dev 28: 2027-2040.

Emerging technologies to map the protein methylome. Carlson SM and O Gozani. 2014. J Mol Biol 426: 3350-3362.

A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions. Gilbert TM, SL McDaniel, SD Byrum, JA Cades, BC Dancy, H Wade, AJ Tackett, BD Strahl and SD Taverna. 2014. Mol Cell Proteomics 13: 2883-2895.

Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation. Esteve PO, J Terragni, K Deepti, HG Chin, N Dai, A Espejo, IR Correa, Jr., MT Bedford and S Pradhan. 2014. J Biol Chem 289: 8277-8287.

Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function. Kim HS, R Mukhopadhyay, SB Rothbart, AC Silva, V Vanoosthuyse, E Radovani, T Kislinger, A Roguev, CJ Ryan, J Xu, H Jahari, KG Hardwick, JF Greenblatt, NJ Krogan, JS Fillingham, BD Strahl, EE Bouhassira, W Edelmann and MC Keogh. 2014. Cell Rep 6: 892-905.

Nuclear PI5P, Uhrf1, and the road not taken. Reynoird N and O Gozani. 2014. Mol Cell 54: 901-903.

SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Mazur PK, N Reynoird, P Khatri, PW Jansen, AW Wilkinson, S Liu, O Barbash, GS Van Aller, M Huddleston, D Dhanak, PJ Tummino, RG Kruger, BA Garcia, AJ Butte, M Vermeulen, J Sage and O Gozani. 2014. Nature 510: 283-287.

A gain-of-function mouse model identifies PRMT6 as a NF-kappaB coactivator. Di Lorenzo A, Y Yang, M Macaluso and MT Bedford. 2014. Nucleic Acids Res 42: 8297-8309.

The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. Klein BJ, L Piao, Y Xi, H Rincon-Arano, SB Rothbart, D Peng, H Wen, C Larson, X Zhang, X Zheng, MA Cortazar, PV Pena, A Mangan, DL Bentley, BD Strahl, M Groudine, W Li, X Shi and TG Kutateladze. 2014. Cell Rep 6: 325-335.

Proteome-wide enrichment of proteins modified by lysine methylation. Carlson SM, KE Moore, EM Green, GM Martin and O Gozani. 2014. Nat Protoc 9: 37-50.

A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation. Dronamraju R and BD Strahl. 2014. Nucleic Acids Res 42: 870-881.

Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Guo A, H Gu, J Zhou, D Mulhern, Y Wang, KA Lee, V Yang, M Aguiar, J Kornhauser, X Jia, J Ren, SA Beausoleil, JC Silva, V Vemulapalli, MT Bedford and MJ Comb. 2014. Mol Cell Proteomics 13: 372-387.

Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Yang Y, KM McBride, S Hensley, Y Lu, F Chedin and MT Bedford. 2014. Mol Cell 53: 484-497.

Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase in osteoclasts. Levy-Apter E, E Finkelshtein, V Vemulapalli, SS Li, MT Bedford and A Elson. 2014. J Biol Chem 289: 36048-36058.

An unexpected journey: lysine methylation across the proteome. Moore KE and O Gozani. 2014. Biochim Biophys Acta 1839: 1395-1403.

Hitting the 'mark': interpreting lysine methylation in the context of active transcription. Wozniak GG and BD Strahl. 2014. Biochim Biophys Acta 1839: 1353-1361.

A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36. Cheng Z, P Cheung, AJ Kuo, ET Yukl, CM Wilmot, O Gozani and DJ Patel. 2014. Genes Dev 28: 1758-1771.

Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor. Carr SM, S Munro, LP Zalmas, O Fedorov, C Johansson, T Krojer, CA Sagum, MT Bedford, U Oppermann and NB La Thangue. 2014. Proc Natl Acad Sci U S A 111: 11341-11346.

Catalysis-dependent stabilization of Bre1 fine-tunes histone H2B ubiquitylation to regulate gene transcription. Wozniak GG and BD Strahl. 2014. Genes Dev 28: 1647-1652.

Readers of histone methylarginine marks. Gayatri S and MT Bedford. 2014. Biochim Biophys Acta 1839: 702-710.

SET-ting the stage for DNA repair. Jha DK, SX Pfister, TC Humphrey and BD Strahl. 2014. Nat Struct Mol Biol 21: 655-657.

Interpreting the language of histone and DNA modifications. Rothbart SB and BD Strahl. 2014. Biochim Biophys Acta 1839: 627-643.

Chromatin biochemistry enters the next generation of code 'seq-ing'. Shanle EK, SB Rothbart and BD Strahl. 2014. Nat Methods 11: 799-800.

Histone-binding domains: strategies for discovery and characterization. Wilkinson AW and O Gozani. 2014. Biochim Biophys Acta 1839: 669-675.

A histone methylation network regulates transgenerational epigenetic memory in C. elegans. Greer EL, SE Beese-Sims, E Brookes, R Spadafora, Y Zhu, SB Rothbart, D Aristizabal-Corrales, S Chen, AI Badeaux, Q Jin, W Wang, BD Strahl, MP Colaiacovo and Y Shi. 2014. Cell Rep 7: 113-126.

Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons. Martin GM, DA King, EM Green, PE Garcia-Nieto, R Alexander, SR Collins, NJ Krogan, OP Gozani and AJ Morrison. 2014. Epigenetics 9: 513-522.

An RNA polymerase II-coupled function for histone H3K36 methylation in checkpoint activation and DSB repair. Jha DK and BD Strahl. 2014. Nat Commun 5: 3965.

Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells. Tosti E, JA Katakowski, S Schaetzlein, HS Kim, CJ Ryan, M Shales, A Roguev, NJ Krogan, D Palliser, MC Keogh and W Edelmann. 2014. Genome Med 6: 68.


Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue. Kinkelin K, GG Wozniak, SB Rothbart, M Lidschreiber, BD Strahl and P Cramer. 2013. Proc Natl Acad Sci U S A 110: 15277-15282.

Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Zheng S, J Moehlenbrink, YC Lu, LP Zalmas, CA Sagum, S Carr, JF McGouran, L Alexander, O Fedorov, S Munro, B Kessler, MT Bedford, Q Yu and NB La Thangue. 2013. Mol Cell 52: 37-51.

Recombinant antibodies to histone post-translational modifications. Hattori T, JM Taft, KM Swist, H Luo, H Witt, M Slattery, A Koide, AJ Ruthenburg, K Krajewski, BD Strahl, KP White, PJ Farnham, Y Zhao and S Koide. 2013. Nat Methods 10: 992-995.

Stress-free with Rpd3: a unique chromatin complex mediates the response to oxidative stress. McDaniel SL and BD Strahl. 2013. Mol Cell Biol 33: 3726-3727.

A TR-FRET-based functional assay for screening activators of CARM1. Zeng H, J Wu, MT Bedford, G Sbardella, FM Hoffmann, K Bi and W Xu. 2013. Chembiochem 14: 827-835.

A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. Moore KE, SM Carlson, ND Camp, P Cheung, RG James, KF Chua, A Wolf-Yadlin and O Gozani. 2013. Mol Cell 50: 444-456.

The carboxyl terminus of Rtt109 functions in chaperone control of histone acetylation. Radovani E, M Cadorin, T Shams, S El-Rass, AR Karsou, HS Kim, CF Kurat, MC Keogh, JF Greenblatt and JS Fillingham. 2013. Eukaryot Cell 12: 654-664.

Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. James LI, D Barsyte-Lovejoy, N Zhong, L Krichevsky, VK Korboukh, JM Herold, CJ MacNevin, JL Norris, CA Sagum, W Tempel, E Marcon, H Guo, C Gao, XP Huang, S Duan, A Emili, JF Greenblatt, DB Kireev, J Jin, WP Janzen, PJ Brown, MT Bedford, CH Arrowsmith and SV Frye. 2013. Nat Chem Biol 9: 184-191.

Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Law JA, J Du, CJ Hale, S Feng, K Krajewski, AM Palanca, BD Strahl, DJ Patel and SE Jacobsen. 2013. Nature 498: 385-389.

Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation. Rothbart SB, BM Dickson, MS Ong, K Krajewski, S Houliston, DB Kireev, CH Arrowsmith and BD Strahl. 2013. Genes Dev 27: 1288-1298.

Dido3 PHD modulates cell differentiation and division. Gatchalian J, A Futterer, SB Rothbart, Q Tong, H Rincon-Arano, A Sanchez de Diego, M Groudine, BD Strahl, AC Martinez, KH van Wely and TG Kutateladze. 2013. Cell Rep 4: 148-158.

Molecular basis for chromatin binding and regulation of MLL5. Ali M, H Rincon-Arano, W Zhao, SB Rothbart, Q Tong, SM Parkhurst, BD Strahl, LW Deng, M Groudine and TG Kutateladze. 2013. Proc Natl Acad Sci U S A 110: 11296-11301.

Chd5 requires PHD-mediated histone 3 binding for tumor suppression. Paul S, A Kuo, T Schalch, H Vogel, L Joshua-Tor, WR McCombie, O Gozani, M Hammell and AA Mills. 2013. Cell Rep 3: 92-102.

Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. Li J, Z Zhao, C Carter, LI Ehrlich, MT Bedford and ER Richie. 2013. J Immunol 190: 597-604.

Protein arginine methyltransferases and cancer. Yang Y and MT Bedford. 2013. Nat Rev Cancer 13: 37-50.

An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Cai L, SB Rothbart, R Lu, B Xu, WY Chen, A Tripathy, S Rockowitz, D Zheng, DJ Patel, CD Allis, BD Strahl, J Song and GG Wang. 2013. Mol Cell 49: 571-582.

Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions. Feng Y, R Maity, JP Whitelegge, A Hadjikyriacou, Z Li, C Zurita-Lopez, Q Al-Hadid, AT Clark, MT Bedford, JY Masson and SG Clarke. 2013. J Biol Chem 288: 37010-37025.

Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage. Bua DJ, GM Martin, O Binda and O Gozani. 2013. Sci Rep 3: 2137.

Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Dhar S, V Vemulapalli, AN Patananan, GL Huang, A Di Lorenzo, S Richard, MJ Comb, A Guo, SG Clarke and MT Bedford. 2013. Sci Rep 3: 1311.


Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Kawabe Y, YX Wang, IW McKinnell, MT Bedford and MA Rudnicki. 2012. Cell Stem Cell 11: 333-345.

Long noncoding RNAs are rarely translated in two human cell lines. Banfai B, H Jia, J Khatun, E Wood, B Risk, WE Gundling, Jr., A Kundaje, HP Gunawardena, Y Yu, L Xie, K Krajewski, BD Strahl, X Chen, P Bickel, MC Giddings, JB Brown and L Lipovich. 2012. Genome Res 22: 1646-1657.

PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Cui G, S Park, AI Badeaux, D Kim, J Lee, JR Thompson, F Yan, S Kaneko, Z Yuan, MV Botuyan, MT Bedford, JQ Cheng and G Mer. 2012. Nat Struct Mol Biol 19: 916-924.

On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions. Price JV, S Tangsombatvisit, G Xu, J Yu, D Levy, EC Baechler, O Gozani, M Varma, PJ Utz and CL Liu. 2012. Nat Med 18: 1434-1440.

DNA replication origin function is promoted by H3K4 di-methylation in Saccharomyces cerevisiae. Rizzardi LF, ES Dorn, BD Strahl and JG Cook. 2012. Genetics 192: 371-384.

Titivated for destruction: the methyl degron. Yang Y and MT Bedford. 2012. Mol Cell 48: 487-488.

Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1. Castellano S, A Spannhoff, C Milite, F Dal Piaz, D Cheng, A Tosco, M Viviano, A Yamani, A Cianciulli, M Sala, V Cura, J Cavarelli, E Novellino, A Mai, MT Bedford and G Sbardella. 2012. J Med Chem 55: 9875-9890.

Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Rothbart SB, K Krajewski, N Nady, W Tempel, S Xue, AI Badeaux, D Barsyte-Lovejoy, JY Martinez, MT Bedford, SM Fuchs, CH Arrowsmith and BD Strahl. 2012. Nat Struct Mol Biol 19: 1155-1160.

Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses. Green EM, G Mas, NL Young, BA Garcia and O Gozani. 2012. Nat Struct Mol Biol 19: 361-363.

Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, A Roguev, K Patrick, J Xu, H Jahari, Z Tong, P Beltrao, M Shales, H Qu, SR Collins, JI Kliegman, L Jiang, D Kuo, E Tosti, HS Kim, W Edelmann, MC Keogh, D Greene, C Tang, P Cunningham, KM Shokat, G Cagney, JP Svensson, C Guthrie, PJ Espenshade, T Ideker and NJ Krogan. 2012. Mol Cell 46: 691-704.

SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Barber MF, E Michishita-Kioi, Y Xi, L Tasselli, M Kioi, Z Moqtaderi, RI Tennen, S Paredes, NL Young, K Chen, K Struhl, BA Garcia, O Gozani, W Li and KF Chua. 2012. Nature 487: 114-118.

New marks on the block: Set5 methylates H4 lysines 5, 8 and 12. Green EM, AJ Morrison and O Gozani. 2012. Nucleus 3: 335-339.

Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Calnan DR, AE Webb, JL White, TR Stowe, T Goswami, X Shi, A Espejo, MT Bedford, O Gozani, SP Gygi and A Brunet. 2012. Aging (Albany NY) 4: 462-479.

RNA polymerase II carboxyl-terminal domain phosphorylation regulates protein stability of the Set2 methyltransferase and histone H3 di- and trimethylation at lysine 36. Fuchs SM, KO Kizer, H Braberg, NJ Krogan and BD Strahl. 2012. J Biol Chem 287: 3249-3256.

The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity. Silva AC, X Xu, HS Kim, J Fillingham, T Kislinger, TA Mennella and MC Keogh. 2012. J Biol Chem 287: 1709-1718.

Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. Badeaux AI, Y Yang, K Cardenas, V Vemulapalli, K Chen, D Kusewitt, E Richie, W Li and MT Bedford. 2012. J Biol Chem 287: 429-437.

Everybody's welcome: The big tent approach to epigenetic drug discovery. Green EM and O Gozani. 2012. Drug Discov Today Ther Strateg 9: e75-e81.

Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin. Ali M, K Yan, ME Lalonde, C Degerny, SB Rothbart, BD Strahl, J Cote, XJ Yang and TG Kutateladze. 2012. J Mol Biol 424: 328-338.

Broad ranges of affinity and specificity of anti-histone antibodies revealed by a quantitative peptide immunoprecipitation assay. Nishikori S, T Hattori, SM Fuchs, N Yasui, J Wojcik, A Koide, BD Strahl and S Koide. 2012. J Mol Biol 424: 391-399.

Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Ballare C, M Lange, A Lapinaite, GM Martin, L Morey, G Pascual, R Liefke, B Simon, Y Shi, O Gozani, T Carlomagno, SA Benitah and L Di Croce. 2012. Nat Struct Mol Biol 19: 1257-1265.

Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer. Stolzenburg S, MG Rots, AS Beltran, AG Rivenbark, X Yuan, H Qian, BD Strahl and P Blancafort. 2012. Nucleic Acids Res 40: 6725-6740.

The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Kuo AJ, J Song, P Cheung, S Ishibe-Murakami, S Yamazoe, JK Chen, DJ Patel and O Gozani. 2012. Nature 484: 115-119.

Epigenetic reprogramming of cancer cells via targeted DNA methylation. Rivenbark AG, S Stolzenburg, AS Beltran, X Yuan, MG Rots, BD Strahl and P Blancafort. 2012. Epigenetics 7: 350-360.

Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Van Aller GS, N Reynoird, O Barbash, M Huddleston, S Liu, AF Zmoos, P McDevitt, R Sinnamon, B Le, G Mas, R Annan, J Sage, BA Garcia, PJ Tummino, O Gozani and RG Kruger. 2012. Epigenetics 7: 340-343.

Methods applied to the study of protein arginine methylation. Cheng D, V Vemulapalli and MT Bedford. 2012. Methods Enzymol 512: 71-92.

Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies. Liu CL, S Tangsombatvisit, JM Rosenberg, G Mandelbaum, EC Gillespie, OP Gozani, AA Alizadeh and PJ Utz. 2012. Arthritis Res Ther 14: R25.

Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30. Liu K, Y Guo, H Liu, C Bian, R Lam, Y Liu, F Mackenzie, LA Rojas, D Reinberg, MT Bedford, RM Xu and J Min. 2012. PLoS One 7: e30375.

Peptide microarrays to interrogate the "histone code". Rothbart SB, K Krajewski, BD Strahl and SM Fuchs. 2012. Methods Enzymol 512: 107-135.

Poly-acetylated chromatin signatures are preferred epitopes for site-specific histone H4 acetyl antibodies. Rothbart SB, S Lin, LM Britton, K Krajewski, MC Keogh, BA Garcia and BD Strahl. 2012. Sci Rep 2: 489.

Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. Zhao H, PC Ho, YH Lo, A Espejo, MT Bedford, MC Hung and SC Wang. 2012. PLoS One 7: e29416.


NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Kuo AJ, P Cheung, K Chen, BM Zee, M Kioi, J Lauring, Y Xi, BH Park, X Shi, BA Garcia, W Li and O Gozani. 2011. Mol Cell 44: 609-620.

Operating on chromatin, a colorful language where context matters. Gardner KE, CD Allis and BD Strahl. 2011. J Mol Biol 409: 36-46.

Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. Chang Y, JR Horton, MT Bedford, X Zhang and X Cheng. 2011. J Mol Biol 408: 807-814.

Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling. Cha B, W Kim, YK Kim, BN Hwang, SY Park, JW Yoon, WS Park, JW Cho, MT Bedford and EH Jho. 2011. Oncogene 30: 2379-2389.

Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. Joo HY, A Jones, C Yang, L Zhai, ADt Smith, Z Zhang, MB Chandrasekharan, ZW Sun, MB Renfrow, Y Wang, C Chang and H Wang. 2011. J Biol Chem 286: 7190-7201.

Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. Spannhoff A, YK Kim, NJ Raynal, V Gharibyan, MB Su, YY Zhou, J Li, S Castellano, G Sbardella, JP Issa and MT Bedford. 2011. EMBO Rep 12: 238-243.

Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bissinger EM, R Heinke, A Spannhoff, A Eberlin, E Metzger, V Cura, P Hassenboehler, J Cavarelli, R Schule, MT Bedford, W Sippl and M Jung. 2011. Bioorg Med Chem 19: 3717-3731.

Antibody recognition of histone post-translational modifications: emerging issues and future prospects. Fuchs SM and BD Strahl. 2011. Epigenomics 3: 247-249.

Regulation of p53 function by lysine methylation. West LE and O Gozani. 2011. Epigenomics 3: 361-369.

Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. Cheng D, S Valente, S Castellano, G Sbardella, R Di Santo, R Costi, MT Bedford and A Mai. 2011. J Med Chem 54: 4928-4932.

Histone arginine methylation. Di Lorenzo A and MT Bedford. 2011. FEBS Lett 585: 2024-2031.

Decoding the trans-histone crosstalk: methods to analyze H2B ubiquitination, H3 methylation and their regulatory factors. Chandrasekharan MB, F Huang and ZW Sun. 2011. Methods 54: 304-314.

Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. Guo Q, MT Bedford and W Fast. 2011. Mol Biosyst 7: 2286-2295.

A chemical method for labeling lysine methyltransferase substrates. Binda O, M Boyce, JS Rush, KK Palaniappan, CR Bertozzi and O Gozani. 2011. Chembiochem 12: 330-334.

Xenoestrogens regulate the activity of arginine methyltransferases. Cheng D and MT Bedford. 2011. Chembiochem 12: 323-329.

Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Lee YH, MT Bedford and MR Stallcup. 2011. Genes Dev 25: 176-188.

Influence of combinatorial histone modifications on antibody and effector protein recognition. Fuchs SM, K Krajewski, RW Baker, VL Miller and BD Strahl. 2011. Curr Biol 21: 53-58.

Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling. Levy D, AJ Kuo, Y Chang, U Schaefer, C Kitson, P Cheung, A Espejo, BM Zee, CL Liu, S Tangsombatvisit, RI Tennen, AY Kuo, S Tanjing, R Cheung, KF Chua, PJ Utz, X Shi, RK Prinjha, K Lee, BA Garcia, MT Bedford, A Tarakhovsky, X Cheng and O Gozani. 2011. Nat Immunol 12: 29-36.

Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Woolard J, W Vousden, SJ Moss, A Krishnakumar, MV Gammons, DG Nowak, N Dixon, J Micklefield, A Spannhoff, MT Bedford, MA Gregory, CJ Martin, PF Leadlay, MQ Zhang, SJ Harper, DO Bates and B Wilkinson. 2011. Chem Sci 2011: 273-278.

Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Hsu JM, CT Chen, CK Chou, HP Kuo, LY Li, CY Lin, HJ Lee, YN Wang, M Liu, HW Liao, B Shi, CC Lai, MT Bedford, CH Tsai and MC Hung. 2011. Nat Cell Biol 13: 174-181.

Hypoxia-induced methylation of a pontin chromatin remodeling factor. Lee JS, Y Kim, J Bhin, HJ Shin, HJ Nam, SH Lee, JB Yoon, O Binda, O Gozani, D Hwang and SH Baek. 2011. Proc Natl Acad Sci U S A 108: 13510-13515.

CUL4B: trash talking at chromatin. Green EM and O Gozani. 2011. Mol Cell 43: 321-323.

Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Chang Y, D Levy, JR Horton, J Peng, X Zhang, O Gozani and X Cheng. 2011. Nucleic Acids Res 39: 6380-6389.

Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. Butler JS, CI Zurita-Lopez, SG Clarke, MT Bedford and SY Dent. 2011. J Biol Chem 286: 12234-12244.

MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Chang Y, L Sun, K Kokura, JR Horton, M Fukuda, A Espejo, V Izumi, JM Koomen, MT Bedford, X Zhang, Y Shinkai, J Fang and X Cheng. 2011. Nat Commun 2: 533.

Identification of lysine 37 of histone H2B as a novel site of methylation. Gardner KE, L Zhou, MA Parra, X Chen and BD Strahl. 2011. PLoS One 6: e16244.

The Ccr4-Not complex interacts with the mRNA export machinery. Kerr SC, N Azzouz, SM Fuchs, MA Collart, BD Strahl, AH Corbett and RN Laribee. 2011. PLoS One 6: e18302.

A proteomic approach for the identification of novel lysine methyltransferase substrates. Levy D, CL Liu, Z Yang, AM Newman, AA Alizadeh, PJ Utz and O Gozani. 2011. Epigenetics Chromatin 4: 19.

Thermodynamic stability of histone H3 is a necessary but not sufficient driving force for its evolutionary conservation. Ramachandran S, L Vogel, BD Strahl and NV Dokholyan. 2011. PLoS Comput Biol 7: e1001042.

2010 and earlier

Decoding chromatin goes high tech. Levy D and O Gozani. 2010. Cell 142: 844-846.

Trimethylation of histone H3 lysine 4 impairs methylation of histone H3 lysine 9: regulation of lysine methyltransferases by physical interaction with their substrates. Binda O, G LeRoy, DJ Bua, BA Garcia, O Gozani and S Richard. 2010. Epigenetics 5: 767-775.

Methylation of the retinoblastoma tumor suppressor by SMYD2. Saddic LA, LE West, A Aslanian, JR Yates, 3rd, SM Rubin, O Gozani and J Sage. 2010. J Biol Chem 285: 37733-37740.

The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression. West LE, S Roy, K Lachmi-Weiner, R Hayashi, X Shi, E Appella, TG Kutateladze and O Gozani. 2010. J Biol Chem 285: 37725-37732.

Hdac3 is essential for the maintenance of chromatin structure and genome stability. Bhaskara S, SK Knutson, G Jiang, MB Chandrasekharan, AJ Wilson, S Zheng, A Yenamandra, K Locke, JL Yuan, AR Bonine-Summers, CE Wells, JF Kaiser, MK Washington, Z Zhao, FF Wagner, ZW Sun, F Xia, EB Holson, D Khabele and SW Hiebert. 2010. Cancer Cell 18: 436-447.

Systematic identification of methyllysine-driven interactions for histone and nonhistone targets. Liu H, M Galka, A Iberg, Z Wang, L Li, C Voss, X Jiang, G Lajoie, Z Huang, MT Bedford and SS Li. 2010. J Proteome Res 9: 5827-5836.

Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. Kokura K, L Sun, MT Bedford and J Fang. 2010. EMBO J 29: 3673-3687.

Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. Roy S, CA Musselman, I Kachirskaia, R Hayashi, KC Glass, JC Nix, O Gozani, E Appella and TG Kutateladze. 2010. J Mol Biol 398: 489-496.

Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Bredfeldt TG, KL Greathouse, SH Safe, MC Hung, MT Bedford and CL Walker. 2010. Mol Endocrinol 24: 993-1006.

AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Short JD, R Dere, KD Houston, SL Cai, J Kim, JM Bergeron, J Shen, J Liang, MT Bedford, GB Mills and CL Walker. 2010. Mol Carcinog 49: 429-439.

Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). Castellano S, C Milite, R Ragno, S Simeoni, A Mai, V Limongelli, E Novellino, I Bauer, G Brosch, A Spannhoff, D Cheng, MT Bedford and G Sbardella. 2010. ChemMedChem 5: 398-414.

Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Greer EL, TJ Maures, AG Hauswirth, EM Green, DS Leeman, GS Maro, S Han, MR Banko, O Gozani and A Brunet. 2010. Nature 466: 383-387.

Mouse models for the p53 R72P polymorphism mimic human phenotypes. Zhu F, ME Dolle, TR Berton, RV Kuiper, C Capps, A Espejo, MJ McArthur, MT Bedford, H van Steeg, A de Vries and DG Johnson. 2010. Cancer Res 70: 5851-5859.

Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription. Chang PY, RA Hom, CA Musselman, L Zhu, A Kuo, O Gozani, TG Kutateladze and ML Cleary. 2010. J Mol Biol 400: 137-144.

Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. Hom RA, PY Chang, S Roy, CA Musselman, KC Glass, AI Selezneva, O Gozani, RF Ismagilov, ML Cleary and TG Kutateladze. 2010. J Mol Biol 400: 145-154.

Negative regulation of hypoxic responses via induced Reptin methylation. Lee JS, Y Kim, IS Kim, B Kim, HJ Choi, JM Lee, HJ Shin, JH Kim, JY Kim, SB Seo, H Lee, O Binda, O Gozani, GL Semenza, M Kim, KI Kim, D Hwang and SH Baek. 2010. Mol Cell 39: 71-85.

Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. Chang Y, T Ganesh, JR Horton, A Spannhoff, J Liu, A Sun, X Zhang, MT Bedford, Y Shinkai, JP Snyder and X Cheng. 2010. J Mol Biol 400: 1-7.

Histone H2B C-terminal helix mediates trans-histone H3K4 methylation independent of H2B ubiquitination. Chandrasekharan MB, F Huang, YC Chen and ZW Sun. 2010. Mol Cell Biol 30: 3216-3232.

CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. O'Brien KB, M Alberich-Jorda, N Yadav, O Kocher, A Diruscio, A Ebralidze, E Levantini, NJ Sng, M Bhasin, T Caron, D Kim, U Steidl, G Huang, B Halmos, SJ Rodig, MT Bedford, DG Tenen and S Kobayashi. 2010. Development 137: 2147-2156.

Enzymatic activity is required for the in vivo functions of CARM1. Kim D, J Lee, D Cheng, J Li, C Carter, E Richie and MT Bedford. 2010. J Biol Chem 285: 1147-1152.

A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Quinn AM, MT Bedford, A Espejo, A Spannhoff, CP Austin, U Oppermann and A Simeonov. 2010. Nucleic Acids Res 38: e11.

TDRD3 is an effector molecule for arginine-methylated histone marks. Yang Y, Y Lu, A Espejo, J Wu, W Xu, S Liang and MT Bedford. 2010. Mol Cell 40: 1016-1023.

Individual lysine acetylations on the N terminus of Saccharomyces cerevisiae H2A.Z are highly but not differentially regulated. Mehta M, H Braberg, S Wang, A Lozsa, M Shales, A Solache, NJ Krogan and MC Keogh. 2010. J Biol Chem 285: 39855-39865.

TRIM24 links a non-canonical histone signature to breast cancer. Tsai WW, Z Wang, TT Yiu, KC Akdemir, W Xia, S Winter, CY Tsai, X Shi, D Schwarzer, W Plunkett, B Aronow, O Gozani, W Fischle, MC Hung, DJ Patel and MC Barton. 2010. Nature 468: 927-932.

Rewiring of genetic networks in response to DNA damage. Bandyopadhyay S, M Mehta, D Kuo, MK Sung, R Chuang, EJ Jaehnig, B Bodenmiller, K Licon, W Copeland, M Shales, D Fiedler, J Dutkowski, A Guenole, H van Attikum, KM Shokat, RD Kolodner, WK Huh, R Aebersold, MC Keogh, NJ Krogan and T Ideker. 2010. Science 330: 1385-1389.

Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation. Chandrasekharan MB, F Huang and ZW Sun. 2010. Epigenetics 5: 460-468.

The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation. Huang F, MB Chandrasekharan, YC Chen, S Bhaskara, SW Hiebert and ZW Sun. 2010. J Biol Chem 285: 24548-24561.

A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Kleine-Kohlbrecher D, J Christensen, J Vandamme, I Abarrategui, M Bak, N Tommerup, X Shi, O Gozani, J Rappsilber, AE Salcini and K Helin. 2010. Mol Cell 38: 165-178.

Sometimes one just isn't enough: do vertebrates contain an H2A.Z hyper-variant?. Mehta M, HS Kim and MC Keogh. 2010. J Biol 9: 3.

The ubiquitin-conjugating enzyme HR6B is required for maintenance of X chromosome silencing in mouse spermatocytes and spermatids. Mulugeta Achame E, E Wassenaar, JW Hoogerbrugge, E Sleddens-Linkels, M Ooms, ZW Sun, IWF van, JA Grootegoed and WM Baarends. 2010. BMC Genomics 11: 367.

Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. Chandrasekharan MB, F Huang and ZW Sun. 2009. Proc Natl Acad Sci U S A 106: 16686-16691.

Crystal structure of the three tandem FF domains of the transcription elongation regulator CA150. Lu M, J Yang, Z Ren, S Sabui, A Espejo, MT Bedford, RH Jacobson, D Jeruzalmi, JS McMurray and X Chen. 2009. J Mol Biol 393: 397-408.

Functional organization of the S. cerevisiae phosphorylation network. Fiedler D, H Braberg, M Mehta, G Chechik, G Cagney, P Mukherjee, AC Silva, M Shales, SR Collins, S van Wageningen, P Kemmeren, FC Holstege, JS Weissman, MC Keogh, D Koller, KM Shokat and NJ Krogan. 2009. Cell 136: 952-963.

Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family. Herrmann F, P Pably, C Eckerich, MT Bedford and FO Fackelmayer. 2009. J Cell Sci 122: 667-677.

Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Chang Y, X Zhang, JR Horton, AK Upadhyay, A Spannhoff, J Liu, JP Snyder, MT Bedford and X Cheng. 2009. Nat Struct Mol Biol 16: 312-317.

ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation. Hung T, O Binda, KS Champagne, AJ Kuo, K Johnson, HY Chang, MD Simon, TG Kutateladze and O Gozani. 2009. Mol Cell 33: 248-256.

HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail. Saksouk N, N Avvakumov, KS Champagne, T Hung, Y Doyon, C Cayrou, E Paquet, M Ullah, AJ Landry, V Cote, XJ Yang, O Gozani, TG Kutateladze and J Cote. 2009. Mol Cell 33: 257-265.

Protein arginine methylation in mammals: who, what, and why. Bedford MT and SG Clarke. 2009. Mol Cell 33: 1-13.

Protein modifications in transcription elongation. Fuchs SM, RN Laribee and BD Strahl. 2009. Biochim Biophys Acta 1789: 26-36.

SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. McCord RA, E Michishita, T Hong, E Berber, LD Boxer, R Kusumoto, S Guan, X Shi, O Gozani, AL Burlingame, VA Bohr and KF Chua. 2009. Aging (Albany NY) 1: 109-121.

EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells. Zagurovskaya M, MM Shareef, A Das, A Reeves, S Gupta, M Sudol, MT Bedford, J Prichard, M Mohiuddin and MM Ahmed. 2009. Oncogene 28: 1121-1131.

Ctk1 promotes dissociation of basal transcription factors from elongating RNA polymerase II. Ahn SH, MC Keogh and S Buratowski. 2009. EMBO J 28: 205-212.

The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. Li Y, P Trojer, CF Xu, P Cheung, A Kuo, WJ Drury, 3rd, Q Qiao, TA Neubert, RM Xu, O Gozani and D Reinberg. 2009. J Biol Chem 284: 34283-34295.

An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe. Kim HS, V Vanoosthuyse, J Fillingham, A Roguev, S Watt, T Kislinger, A Treyer, LR Carpenter, CS Bennett, A Emili, JF Greenblatt, KG Hardwick, NJ Krogan, J Bahler and MC Keogh. 2009. Nat Struct Mol Biol 16: 1286-1293.

Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Michishita E, RA McCord, LD Boxer, MF Barber, T Hong, O Gozani and KF Chua. 2009. Cell Cycle 8: 2664-2666.

Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. Nakanishi S, JS Lee, KE Gardner, JM Gardner, YH Takahashi, MB Chandrasekharan, ZW Sun, MA Osley, BD Strahl, SL Jaspersen and A Shilatifard. 2009. J Cell Biol 186: 371-377.

Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. Xie Y, S Ke, N Ouyang, J He, W Xie, MT Bedford and Y Tian. 2009. J Biol Chem 284: 9199-9205.

Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Dacwag CS, MT Bedford, S Sif and AN Imbalzano. 2009. Mol Cell Biol 29: 1909-1921.

NMR assignments and histone specificity of the ING2 PHD finger. Pena PV, CA Musselman, AJ Kuo, O Gozani and TG Kutateladze. 2009. Magn Reson Chem 47: 352-358.

IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. Repass JF, MN Laurent, C Carter, B Reizis, MT Bedford, K Cardenas, P Narang, M Coles and ER Richie. 2009. Genesis 47: 281-287.

Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks. Bua DJ, AJ Kuo, P Cheung, CL Liu, V Migliori, A Espejo, F Casadio, C Bassi, B Amati, MT Bedford, E Guccione and O Gozani. 2009. PLoS One 4: e6789.

Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. Ito T, N Yadav, J Lee, T Furumatsu, S Yamashita, K Yoshida, N Taniguchi, M Hashimoto, M Tsuchiya, T Ozaki, M Lotz, MT Bedford and H Asahara. 2009. BMC Dev Biol 9: 47.

The Set2/Rpd3S pathway suppresses cryptic transcription without regard to gene length or transcription frequency. Lickwar CR, B Rao, AA Shabalin, AB Nobel, BD Strahl and JD Lieb. 2009. PLoS One 4: e4886.

Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. Ludes-Meyers JH, H Kil, J Parker-Thornburg, DF Kusewitt, MT Bedford and CM Aldaz. 2009. PLoS One 4: e7775.

Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Koh AS, AJ Kuo, SY Park, P Cheung, J Abramson, D Bua, D Carney, SE Shoelson, O Gozani, RE Kingston, C Benoist and D Mathis. 2008. Proc Natl Acad Sci U S A 105: 15878-15883.

Epigenomics: a roadmap to chromatin. Henikoff S, BD Strahl and PE Warburton. 2008. Science 322: 853.

Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. Hassa PO, M Covic, MT Bedford and MO Hottiger. 2008. J Mol Biol 377: 668-678.

SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Michishita E, RA McCord, E Berber, M Kioi, H Padilla-Nash, M Damian, P Cheung, R Kusumoto, TL Kawahara, JC Barrett, HY Chang, VA Bohr, T Ried, O Gozani and KF Chua. 2008. Nature 452: 492-496.

Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. Pena PV, RA Hom, T Hung, H Lin, AJ Kuo, RP Wong, OM Subach, KS Champagne, R Zhao, VV Verkhusha, G Li, O Gozani and TG Kutateladze. 2008. J Mol Biol 380: 303-312.

Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Fillingham J, J Recht, AC Silva, B Suter, A Emili, I Stagljar, NJ Krogan, CD Allis, MC Keogh and JF Greenblatt. 2008. Mol Cell Biol 28: 4342-4353.

Arginine methylation of the histone H3 tail impedes effector binding. Iberg AN, A Espejo, D Cheng, D Kim, J Michaud-Levesque, S Richard and MT Bedford. 2008. J Biol Chem 283: 3006-3010.

CARM1 promotes adipocyte differentiation by coactivating PPARgamma. Yadav N, D Cheng, S Richard, M Morel, VR Iyer, CM Aldaz and MT Bedford. 2008. EMBO Rep 9: 193-198.

Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling. Kachirskaia I, X Shi, H Yamaguchi, K Tanoue, H Wen, EW Wang, E Appella and O Gozani. 2008. J Biol Chem 283: 34660-34666.

The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. Merker JD, M Dominska, PW Greenwell, E Rinella, DC Bouck, Y Shibata, BD Strahl, P Mieczkowski and TD Petes. 2008. DNA Repair (Amst) 7: 1298-1308.

A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Schotta G, R Sengupta, S Kubicek, S Malin, M Kauer, E Callen, A Celeste, M Pagani, S Opravil, IA De La Rosa-Velazquez, A Espejo, MT Bedford, A Nussenzweig, M Busslinger and T Jenuwein. 2008. Genes Dev 22: 2048-2061.

Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36. Youdell ML, KO Kizer, E Kisseleva-Romanova, SM Fuchs, E Duro, BD Strahl and J Mellor. 2008. Mol Cell Biol 28: 4915-4926.

Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Bhaskara S, BJ Chyla, JM Amann, SK Knutson, D Cortez, ZW Sun and SW Hiebert. 2008. Mol Cell 30: 61-72.

epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. Mai A, D Cheng, MT Bedford, S Valente, A Nebbioso, A Perrone, G Brosch, G Sbardella, F De Bellis, M Miceli and L Altucci. 2008. J Med Chem 51: 2279-2290.

p53 is regulated by the lysine demethylase LSD1. Huang J, R Sengupta, AB Espejo, MG Lee, JA Dorsey, M Richter, S Opravil, R Shiekhattar, MT Bedford, T Jenuwein and SL Berger. 2007. Nature 449: 105-108.

Molecular biology. Unlocking cell fate. Rivenbark AG and BD Strahl. 2007. Science 318: 403-404.

Carcinogen-induced histone alteration in normal human mammary epithelial cells. Bradley C, R van der Meer, N Roodi, H Yan, MB Chandrasekharan, ZW Sun, RL Mernaugh and FF Parl. 2007. Carcinogenesis 28: 2184-2192.

The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2. Ramon-Maiques S, AJ Kuo, D Carney, AG Matthews, MA Oettinger, O Gozani and W Yang. 2007. Proc Natl Acad Sci U S A 104: 18993-18998.

Stabilized phosphatidylinositol-5-phosphate analogues as ligands for the nuclear protein ING2: chemistry, biology, and molecular modeling. Huang W, H Zhang, F Davrazou, TG Kutateladze, X Shi, O Gozani and GD Prestwich. 2007. J Am Chem Soc 129: 6498-6506.

Protein methylation and DNA repair. Lake AN and MT Bedford. 2007. Mutat Res 618: 91-101.

Organismal differences in post-translational modifications in histones H3 and H4. Garcia BA, SB Hake, RL Diaz, M Kauer, SA Morris, J Recht, J Shabanowitz, N Mishra, BD Strahl, CD Allis and DF Hunt. 2007. J Biol Chem 282: 7641-7655.

Identification of histone H3 lysine 36 acetylation as a highly conserved histone modification. Morris SA, B Rao, BA Garcia, SB Hake, RL Diaz, J Shabanowitz, DF Hunt, CD Allis, JD Lieb and BD Strahl. 2007. J Biol Chem 282: 7632-7640.

Reprogramming the histone code. Shaaban SA and MT Bedford. 2007. Chem Biol 14: 242-244.

Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice. Swiercz R, D Cheng, D Kim and MT Bedford. 2007. J Biol Chem 282: 16917-16923.

Increased phosphorylation and dimethylation of XY body histones in the Hr6b-knockout mouse is associated with derepression of the X chromosome. Baarends WM, E Wassenaar, JW Hoogerbrugge, S Schoenmakers, ZW Sun and JA Grootegoed. 2007. J Cell Sci 120: 1841-1851.

H2B ubiquitylation acts as a barrier to Ctk1 nucleosomal recruitment prior to removal by Ubp8 within a SAGA-related complex. Wyce A, T Xiao, KA Whelan, C Kosman, W Walter, D Eick, TR Hughes, NJ Krogan, BD Strahl and SL Berger. 2007. Mol Cell 27: 275-288.

Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors. Mai A, S Valente, D Cheng, A Perrone, R Ragno, S Simeoni, G Sbardella, G Brosch, A Nebbioso, M Conte, L Altucci and MT Bedford. 2007. ChemMedChem 2: 987-991.

Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. Shi X, I Kachirskaia, KL Walter, JH Kuo, A Lake, F Davrazou, SM Chan, DG Martin, IM Fingerman, SD Briggs, L Howe, PJ Utz, TG Kutateladze, AA Lugovskoy, MT Bedford and O Gozani. 2007. J Biol Chem 282: 2450-2455.

The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Cheng D, J Cote, S Shaaban and MT Bedford. 2007. Mol Cell 25: 71-83.

The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Naeem H, D Cheng, Q Zhao, C Underhill, M Tini, MT Bedford and J Torchia. 2007. Mol Cell Biol 27: 120-134.

The RNA polymerase II kinase Ctk1 regulates positioning of a 5' histone methylation boundary along genes. Xiao T, Y Shibata, B Rao, RN Laribee, R O'Rourke, MJ Buck, JF Greenblatt, NJ Krogan, JD Lieb and BD Strahl. 2007. Mol Cell Biol 27: 721-731.

Arginine methylation at a glance. Bedford MT. 2007. J Cell Sci 120: 4243-4246.

Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. Sayegh J, K Webb, D Cheng, MT Bedford and SG Clarke. 2007. J Biol Chem 282: 36444-36453.

RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Matthews AG, AJ Kuo, S Ramon-Maiques, S Han, KS Champagne, D Ivanov, M Gallardo, D Carney, P Cheung, DN Ciccone, KL Walter, PJ Utz, Y Shi, TG Kutateladze, W Yang, O Gozani and MA Oettinger. 2007. Nature 450: 1106-1110.

WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Ludes-Meyers JH, H Kil, MI Nunez, CJ Conti, J Parker-Thornburg, MT Bedford and CM Aldaz. 2007. Genes Chromosomes Cancer 46: 1129-1136.

Modulation of p53 function by SET8-mediated methylation at lysine 382. Shi X, I Kachirskaia, H Yamaguchi, LE West, H Wen, EW Wang, S Dutta, E Appella and O Gozani. 2007. Mol Cell 27: 636-646.

Recognition of unmethylated histone H3 lysine 4 links BHC80 to LSD1-mediated gene repression. Lan F, RE Collins, R De Cegli, R Alpatov, JR Horton, X Shi, O Gozani, X Cheng and Y Shi. 2007. Nature 448: 718-722.

CCR4/NOT complex associates with the proteasome and regulates histone methylation. Laribee RN, Y Shibata, DP Mersman, SR Collins, P Kemmeren, A Roguev, JS Weissman, SD Briggs, NJ Krogan and BD Strahl. 2007. Proc Natl Acad Sci U S A 104: 5836-5841.

H2B ubiquitylation in transcriptional control: a FACT-finding mission. Laribee RN, SM Fuchs and BD Strahl. 2007. Genes Dev 21: 737-743.

Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. El Messaoudi S, E Fabbrizio, C Rodriguez, P Chuchana, L Fauquier, D Cheng, C Theillet, L Vandel, MT Bedford and C Sardet. 2006. Proc Natl Acad Sci U S A 103: 13351-13356.

Opposing roles for Set2 and yFACT in regulating TBP binding at promoters. Biswas D, R Dutta-Biswas, D Mitra, Y Shibata, BD Strahl, T Formosa and DJ Stillman. 2006. EMBO J 25: 4479-4489.

The Yng1p plant homeodomain finger is a methyl-histone binding module that recognizes lysine 4-methylated histone H3. Martin DG, K Baetz, X Shi, KL Walter, VE MacDonald, MJ Wlodarski, O Gozani, P Hieter and L Howe. 2006. Mol Cell Biol 26: 7871-7879.

Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Huang Y, J Fang, MT Bedford, Y Zhang and RM Xu. 2006. Science 312: 748-751.

The Saccharomyces cerevisiae histone H2A variant Htz1 is acetylated by NuA4. Keogh MC, TA Mennella, C Sawa, S Berthelet, NJ Krogan, A Wolek, V Podolny, LR Carpenter, JF Greenblatt, K Baetz and S Buratowski. 2006. Genes Dev 20: 660-665.

PtdIns5P activates the host cell PI3-kinase/Akt pathway during Shigella flexneri infection. Pendaries C, H Tronchere, L Arbibe, J Mounier, O Gozani, L Cantley, MJ Fry, F Gaits-Iacovoni, PJ Sansonetti and B Payrastre. 2006. EMBO J 25: 1024-1034.

Molecular mechanism of histone H3K4me3 recognition by plant homeodomain of ING2. Pena PV, F Davrazou, X Shi, KL Walter, VV Verkhusha, O Gozani, R Zhao and TG Kutateladze. 2006. Nature 442: 100-103.

ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Shi X, T Hong, KL Walter, M Ewalt, E Michishita, T Hung, D Carney, P Pena, F Lan, MR Kaadige, N Lacoste, C Cayrou, F Davrazou, A Saha, BR Cairns, DE Ayer, TG Kutateladze, Y Shi, J Cote, KF Chua and O Gozani. 2006. Nature 442: 96-99.

A phosphatase complex that dephosphorylates gammaH2AX regulates DNA damage checkpoint recovery. Keogh MC, JA Kim, M Downey, J Fillingham, D Chowdhury, JC Harrison, M Onishi, N Datta, S Galicia, A Emili, J Lieberman, X Shen, S Buratowski, JE Haber, D Durocher, JF Greenblatt and NJ Krogan. 2006. Nature 439: 497-501.

The Set2 methyltransferase associates with Ssn6 yet Tup1-Ssn6 repression is independent of histone methylation. Tripic T, DG Edmondson, JK Davie, BD Strahl and SY Dent. 2006. Biochem Biophys Res Commun 339: 905-914.

Structure and carboxyl-terminal domain (CTD) binding of the Set2 SRI domain that couples histone H3 Lys36 methylation to transcription. Vojnic E, B Simon, BD Strahl, M Sattler and P Cramer. 2006. J Biol Chem 281: 13-15.

The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. Sgarra R, J Lee, MA Tessari, S Altamura, B Spolaore, V Giancotti, MT Bedford and G Manfioletti. 2006. J Biol Chem 281: 3764-3772.

Accelerated nuclei preparation and methods for analysis of histone modifications in yeast. Kizer KO, T Xiao and BD Strahl. 2006. Methods 40: 296-302.

GammaH2AX and its role in DNA double-strand break repair. Fillingham J, MC Keogh and NJ Krogan. 2006. Biochem Cell Biol 84: 568-577.

Tudor, MBT and chromo domains gauge the degree of lysine methylation. Kim J, J Daniel, A Espejo, A Lake, M Krishna, L Xia, Y Zhang and MT Bedford. 2006. EMBO Rep 7: 397-403.

PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. Lee J, J Sayegh, J Daniel, S Clarke and MT Bedford. 2005. J Biol Chem 280: 32890-32896.

Cotranscriptional set2 methylation of histone H3 lysine 36 recruits a repressive Rpd3 complex. Keogh MC, SK Kurdistani, SA Morris, SH Ahn, V Podolny, SR Collins, M Schuldiner, K Chin, T Punna, NJ Thompson, C Boone, A Emili, JS Weissman, TR Hughes, BD Strahl, M Grunstein, JF Greenblatt, S Buratowski and NJ Krogan. 2005. Cell 123: 593-605.

Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo. Herrmann F, J Lee, MT Bedford and FO Fackelmayer. 2005. J Biol Chem 280: 38005-38010.

Dimethylation of histone H3 at lysine 36 demarcates regulatory and nonregulatory chromatin genome-wide. Rao B, Y Shibata, BD Strahl and JD Lieb. 2005. Mol Cell Biol 25: 9447-9459.

BRCA1/BARD1 ubiquitinate phosphorylated RNA polymerase II. Starita LM, AA Horwitz, MC Keogh, C Ishioka, JD Parvin and N Chiba. 2005. J Biol Chem 280: 24498-24505.

Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. Covic M, PO Hassa, S Saccani, C Buerki, NI Meier, C Lombardi, R Imhof, MT Bedford, G Natoli and MO Hottiger. 2005. EMBO J 24: 85-96.

Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression. Boulanger MC, C Liang, RS Russell, R Lin, MT Bedford, MA Wainberg and S Richard. 2005. J Virol 79: 124-131.

Histone H2B ubiquitylation is associated with elongating RNA polymerase II. Xiao T, CF Kao, NJ Krogan, ZW Sun, JF Greenblatt, MA Osley and BD Strahl. 2005. Mol Cell Biol 25: 637-651.

Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). Swiercz R, MD Person and MT Bedford. 2005. Biochem J 386: 85-91.

The fellowships of the INGs. Shi X and O Gozani. 2005. J Cell Biochem 96: 1127-1136.

gamma-H2AX dephosphorylation by protein phosphatase 2A facilitates DNA double-strand break repair. Chowdhury D, MC Keogh, H Ishii, CL Peterson, S Buratowski and J Lieberman. 2005. Mol Cell 20: 801-809.

Translating the histone code into leukemia. Linggi BE, SJ Brandt, ZW Sun and SW Hiebert. 2005. J Cell Biochem 96: 938-950.

BUR kinase selectively regulates H3 K4 trimethylation and H2B ubiquitylation through recruitment of the PAF elongation complex. Laribee RN, NJ Krogan, T Xiao, Y Shibata, TR Hughes, JF Greenblatt and BD Strahl. 2005. Curr Biol 15: 1487-1493.

A PHD finger motif in the C terminus of RAG2 modulates recombination activity. Elkin SK, D Ivanov, M Ewalt, CG Ferguson, SG Hyberts, ZY Sun, GD Prestwich, J Yuan, G Wagner, MA Oettinger and OP Gozani. 2005. J Biol Chem 280: 28701-28710.

Methylation of histone H3 lysine 36 is required for normal development in Neurospora crassa. Adhvaryu KK, SA Morris, BD Strahl and EU Selker. 2005. Eukaryot Cell 4: 1455-1464.

Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe. Morris SA, Y Shibata, K Noma, Y Tsukamoto, E Warren, B Temple, SI Grewal and BD Strahl. 2005. Eukaryot Cell 4: 1446-1454.

Arginine methylation an emerging regulator of protein function. Bedford MT and S Richard. 2005. Mol Cell 18: 263-272.

A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. Kizer KO, HP Phatnani, Y Shibata, H Hall, AL Greenleaf and BD Strahl. 2005. Mol Cell Biol 25: 3305-3316.

Role of protein methylation in regulation of transcription. Lee DY, C Teyssier, BD Strahl and MR Stallcup. 2005. Endocr Rev 26: 147-170.

Evidence that the Tfg1/Tfg2 dimer interface of TFIIF lies near the active center of the RNA polymerase II initiation complex. Freire-Picos MA, S Krishnamurthy, ZW Sun and M Hampsey. 2005. Nucleic Acids Res 33: 5045-5052.

Modification of protein sub-nuclear localization by synthetic phosphoinositides: evidence for nuclear phosphoinositide signaling mechanisms. Gozani O, SJ Field, CG Ferguson, M Ewalt, C Mahlke, LC Cantley, GD Prestwich and J Yuan. 2005. Adv Enzyme Regul 45: 171-185.

Regulation of chromosome stability by the histone H2A variant Htz1, the Swr1 chromatin remodeling complex, and the histone acetyltransferase NuA4. Krogan NJ, K Baetz, MC Keogh, N Datta, C Sawa, TC Kwok, NJ Thompson, MG Davey, J Pootoolal, TR Hughes, A Emili, S Buratowski, P Hieter and JF Greenblatt. 2004. Proc Natl Acad Sci U S A 101: 13513-13518.

Multiple classes of MSL binding sites target dosage compensation to the X chromosome of Drosophila. Oh H, JR Bone and MI Kuroda. 2004. Curr Biol 14: 481-487.

WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Ludes-Meyers JH, H Kil, AK Bednarek, J Drake, MT Bedford and CM Aldaz. 2004. Oncogene 23: 5049-5055.

Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development. Kim J, J Lee, N Yadav, Q Wu, C Carter, S Richard, E Richie and MT Bedford. 2004. J Biol Chem 279: 25339-25344.

Small molecule regulators of protein arginine methyltransferases. Cheng D, N Yadav, RW King, MS Swanson, EJ Weinstein and MT Bedford. 2004. J Biol Chem 279: 23892-23899.

Deubiquitination of histone H2B by a yeast acetyltransferase complex regulates transcription. Daniel JA, MS Torok, ZW Sun, D Schieltz, CD Allis, JR Yates, 3rd and PA Grant. 2004. J Biol Chem 279: 1867-1871.

Proteasome involvement in the repair of DNA double-strand breaks. Krogan NJ, MH Lam, J Fillingham, MC Keogh, M Gebbia, J Li, N Datta, G Cagney, S Buratowski, A Emili and JF Greenblatt. 2004. Mol Cell 16: 1027-1034.

Evidence for nucleosome depletion at active regulatory regions genome-wide. Lee CK, Y Shibata, B Rao, BD Strahl and JD Lieb. 2004. Nat Genet 36: 900-905.

Protein-domain microarrays. Espejo A and MT Bedford. 2004. Methods Mol Biol 264: 173-181.

Using chromatin immunoprecipitation to map cotranscriptional mRNA processing in Saccharomyces cerevisiae. Keogh MC and S Buratowski. 2004. Methods Mol Biol 257: 1-16.

Techniques in protein methylation. Lee J, D Cheng and MT Bedford. 2004. Methods Mol Biol 284: 195-208.

Targeting dosage compensation to the X chromosome of Drosophila males. Oh H, X Bai, Y Park, JR Bone and MI Kuroda. 2004. Cold Spring Harb Symp Quant Biol 69: 81-88.

Bur1 kinase is required for efficient transcription elongation by RNA polymerase II. Keogh MC, V Podolny and S Buratowski. 2003. Mol Cell Biol 23: 7005-7018.

Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Yadav N, J Lee, J Kim, J Shen, MC Hu, CM Aldaz and MT Bedford. 2003. Proc Natl Acad Sci U S A 100: 6464-6468.

Phosphorylation of RNA polymerase II CTD regulates H3 methylation in yeast. Xiao T, H Hall, KO Kizer, Y Shibata, MC Hall, CH Borchers and BD Strahl. 2003. Genes Dev 17: 654-663.

A nucleosomal function for IkappaB kinase-alpha in NF-kappaB-dependent gene expression. Anest V, JL Hanson, PC Cogswell, KA Steinbrecher, BD Strahl and AS Baldwin. 2003. Nature 423: 659-663.

The PHD finger of the chromatin-associated protein ING2 functions as a nuclear phosphoinositide receptor. Gozani O, P Karuman, DR Jones, D Ivanov, J Cha, AA Lugovskoy, CL Baird, H Zhu, SJ Field, SL Lessnick, J Villasenor, B Mehrotra, J Chen, VR Rao, JS Brugge, CG Ferguson, B Payrastre, DG Myszka, LC Cantley, G Wagner, N Divecha, GD Prestwich and J Yuan. 2003. Cell 114: 99-111.

Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Cote J, FM Boisvert, MC Boulanger, MT Bedford and S Richard. 2003. Mol Biol Cell 14: 274-287.

Resetting the histone code at CDKN2A in HNSCC by inhibition of DNA methylation. Coombes MM, KL Briggs, JR Bone, GL Clayman, AK El-Naggar and SY Dent. 2003. Oncogene 22: 8902-8911.

A Snf2 family ATPase complex required for recruitment of the histone H2A variant Htz1. Krogan NJ, MC Keogh, N Datta, C Sawa, OW Ryan, H Ding, RA Haw, J Pootoolal, A Tong, V Canadien, DP Richards, X Wu, A Emili, TR Hughes, S Buratowski and JF Greenblatt. 2003. Mol Cell 12: 1565-1576.

14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s). Liu MY, S Cai, A Espejo, MT Bedford and CL Walker. 2002. Cancer Res 62: 6475-6480.

A protein-domain microarray identifies novel protein-protein interactions. Espejo A, J Cote, A Bednarek, S Richard and MT Bedford. 2002. Biochem J 367: 697-702.

Unraveling heterochromatin. Briggs SD and BD Strahl. 2002. Nat Genet 30: 241-242.

Kin28 is found within TFIIH and a Kin28-Ccl1-Tfb3 trimer complex with differential sensitivities to T-loop phosphorylation. Keogh MC, EJ Cho, V Podolny and S Buratowski. 2002. Mol Cell Biol 22: 1288-1297.

PABP1 identified as an arginine methyltransferase substrate using high-density protein arrays. Lee J and MT Bedford. 2002. EMBO Rep 3: 268-273.

Set2 is a nucleosomal histone H3-selective methyltransferase that mediates transcriptional repression. Strahl BD, PA Grant, SD Briggs, ZW Sun, JR Bone, JA Caldwell, S Mollah, RG Cook, J Shabanowitz, DF Hunt and CD Allis. 2002. Mol Cell Biol 22: 1298-1306.

Life and death in paradise. Gozani O, M Boyce, L Yoo, P Karuman and J Yuan. 2002. Nat Cell Biol 4: E159-162.

Divergent subunit interactions among fungal mRNA 5'-capping machineries. Takagi T, EJ Cho, RT Janoo, V Polodny, Y Takase, MC Keogh, SA Woo, LD Fresco-Cohen, CS Hoffman and S Buratowski. 2002. Eukaryot Cell 1: 448-457.

Ubiquitination of histone H2B regulates H3 methylation and gene silencing in yeast. Sun ZW and CD Allis. 2002. Nature 418: 104-108.

Evidence that Set1, a factor required for methylation of histone H3, regulates rDNA silencing in S. cerevisiae by a Sir2-independent mechanism. Bryk M, SD Briggs, BD Strahl, MJ Curcio, CD Allis and F Winston. 2002. Curr Biol 12: 165-170.

Normalization of nomenclature for peptide motifs as ligands of modular protein domains. Aasland R, C Abrams, C Ampe, LJ Ball, MT Bedford, G Cesareni, M Gimona, JH Hurley, T Jarchau, VP Lehto, MA Lemmon, R Linding, BJ Mayer, M Nagai, M Sudol, U Walter and SJ Winder. 2002. FEBS Lett 513: 141-144.

The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. Frankel A, N Yadav, J Lee, TL Branscombe, S Clarke and MT Bedford. 2002. J Biol Chem 277: 3537-3543.

Gene silencing: trans-histone regulatory pathway in chromatin. Briggs SD, T Xiao, ZW Sun, JA Caldwell, J Shabanowitz, DF Hunt, CD Allis and BD Strahl. 2002. Nature 418: 498.

Involvement of histone methylation and phosphorylation in regulation of transcription by thyroid hormone receptor. Li J, Q Lin, HG Yoon, ZQ Huang, BD Strahl, CD Allis and J Wong. 2002. Mol Cell Biol 22: 5688-5697.

The nature of FSH induction by GnRH. Miller WL, F Shafiee-Kermani, BD Strahl and HJ Huang. 2002. Trends Endocrinol Metab 13: 257-263.

The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. Goldstrohm AC, TR Albrecht, C Sune, MT Bedford and MA Garcia-Blanco. 2001. Mol Cell Biol 21: 7617-7628.

A Gal4-sigma 54 hybrid protein that functions as a potent activator of RNA polymerase II transcription in yeast. Chen BS, ZW Sun and M Hampsey. 2001. J Biol Chem 276: 23881-23887.

Methylation of histone H4 at arginine 3 occurs in vivo and is mediated by the nuclear receptor coactivator PRMT1. Strahl BD, SD Briggs, CJ Brame, JA Caldwell, SS Koh, H Ma, RG Cook, J Shabanowitz, DF Hunt, MR Stallcup and CD Allis. 2001. Curr Biol 11: 996-1000.

Transcriptional regulation of the ovine follicle-stimulating hormone-beta gene by activin and gonadotropin-releasing hormone (GnRH): involvement of two proximal activator protein-1 sites for GnRH stimulation. Huang HJ, J Sebastian, BD Strahl, JC Wu and WL Miller. 2001. Endocrinology 142: 2267-2274.

The promoter for the ovine follicle-stimulating hormone-beta gene (FSHbeta) confers FSHbeta-like expression on luciferase in transgenic mice: regulatory studies in vivo and in vitro. Huang HJ, J Sebastian, BD Strahl, JC Wu and WL Miller. 2001. Endocrinology 142: 2260-2266.

The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death. Karuman P, O Gozani, RD Odze, XC Zhou, H Zhu, R Shaw, TP Brien, CD Bozzuto, D Ooi, LC Cantley and J Yuan. 2001. Mol Cell 7: 1307-1319.

Recruitment of the yeast Tup1p-Ssn6p repressor is associated with localized decreases in histone acetylation. Bone JR and SY Roth. 2001. J Biol Chem 276: 1808-1813.

Histone H3 lysine 4 methylation is mediated by Set1 and required for cell growth and rDNA silencing in Saccharomyces cerevisiae. Briggs SD, M Bryk, BD Strahl, WL Cheung, JK Davie, SY Dent, F Winston and CD Allis. 2001. Genes Dev 15: 3286-3295.

Hormone-dependent, CARM1-directed, arginine-specific methylation of histone H3 on a steroid-regulated promoter. Ma H, CT Baumann, H Li, BD Strahl, R Rice, MA Jelinek, DW Aswad, CD Allis, GL Hager and MR Stallcup. 2001. Curr Biol 11: 1981-1985.

Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins. Sotgia F, H Lee, MT Bedford, T Petrucci, M Sudol and MP Lisanti. 2001. Biochemistry 40: 14585-14592.

Methylation of histone H4 at arginine 3 facilitating transcriptional activation by nuclear hormone receptor. Wang H, ZQ Huang, L Xia, Q Feng, H Erdjument-Bromage, BD Strahl, SD Briggs, CD Allis, J Wong, P Tempst and Y Zhang. 2001. Science 293: 853-857.

Role of histone H3 lysine 9 methylation in epigenetic control of heterochromatin assembly. Nakayama J, JC Rice, BD Strahl, CD Allis and SI Grewal. 2001. Science 292: 110-113.

Corepressor proteins and control of transcription in yeast. Bone JR and SY Roth. 2001. Curr Top Microbiol Immunol 254: 59-78.

Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis. Passani LA, MT Bedford, PW Faber, KM McGinnis, AH Sharp, JF Gusella, JP Vonsattel and ME MacDonald. 2000. Hum Mol Genet 9: 2175-2182.

Ssn6-Tup1 interacts with class I histone deacetylases required for repression. Watson AD, DG Edmondson, JR Bone, Y Mukai, Y Yu, W Du, DJ Stillman and SY Roth. 2000. Genes Dev 14: 2737-2744.

Arginine methylation inhibits the binding of proline-rich ligands to Src homology 3, but not WW, domains. Bedford MT, A Frankel, MB Yaffe, S Clarke, P Leder and S Richard. 2000. J Biol Chem 275: 16030-16036.

The language of covalent histone modifications. Strahl BD and CD Allis. 2000. Nature 403: 41-45.

Kin28, the TFIIH-associated carboxy-terminal domain kinase, facilitates the recruitment of mRNA processing machinery to RNA polymerase II. Rodriguez CR, EJ Cho, MC Keogh, CL Moore, AL Greenleaf and S Buratowski. 2000. Mol Cell Biol 20: 104-112.

Regulation of chromatin structure by site-specific histone H3 methyltransferases. Rea S, F Eisenhaber, D O'Carroll, BD Strahl, ZW Sun, M Schmid, S Opravil, K Mechtler, CP Ponting, CD Allis and T Jenuwein. 2000. Nature 406: 593-599.

Mitotic phosphorylation of histone H3 is governed by Ipl1/aurora kinase and Glc7/PP1 phosphatase in budding yeast and nematodes. Hsu JY, ZW Sun, X Li, M Reuben, K Tatchell, DK Bishop, JM Grushcow, CJ Brame, JA Caldwell, DF Hunt, R Lin, MM Smith and CD Allis. 2000. Cell 102: 279-291.

A novel pro-Arg motif recognized by WW domains. Bedford MT, D Sarbassova, J Xu, P Leder and MB Yaffe. 2000. J Biol Chem 275: 10359-10369.

Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. Das BK, L Xia, L Palandjian, O Gozani, Y Chyung and R Reed. 1999. Mol Cell Biol 19: 6796-6802.

Tissue-selective expression of dominant-negative proteins for the regulation of vascular smooth muscle cell proliferation. Schmitt JF, MC Keogh, U Dennehy, D Chen, F Lupu, K Weston, D Taylor, VV Kakkar and NR Lemoine. 1999. Gene Ther 6: 1184-1191.

The FF domain: a novel motif that often accompanies WW domains. Bedford MT and P Leder. 1999. Trends Biochem Sci 24: 264-265.

A general requirement for the Sin3-Rpd3 histone deacetylase complex in regulating silencing in Saccharomyces cerevisiae. Sun ZW and M Hampsey. 1999. Genetics 152: 921-932.

Methylation of histone H3 at lysine 4 is highly conserved and correlates with transcriptionally active nuclei in Tetrahymena. Strahl BD, R Ohba, RG Cook and CD Allis. 1999. Proc Natl Acad Sci U S A 96: 14967-14972.

Design of a muscle cell-specific expression vector utilising human vascular smooth muscle alpha-actin regulatory elements. Keogh MC, D Chen, JF Schmitt, U Dennehy, VV Kakkar and NR Lemoine. 1999. Gene Ther 6: 616-628.

The WW domain of dystrophin requires EF-hands region to interact with beta-dystroglycan. Rentschler S, H Linn, K Deininger, MT Bedford, X Espanel and M Sudol. 1999. Biol Chem 380: 431-442.

Efficient liposome-mediated gene transfer to rabbit carotid arteries in vivo. Keogh MC and D Chen. 1999. Methods Mol Med 30: 385-394.

WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Bedford MT, R Reed and P Leder. 1998. Proc Natl Acad Sci U S A 95: 10602-10607.

Transcriptional activation of the ovine follicle-stimulating hormone beta-subunit gene by gonadotropin-releasing hormone: involvement of two activating protein-1-binding sites and protein kinase C. Strahl BD, HJ Huang, J Sebastian, BR Ghosh and WL Miller. 1998. Endocrinology 139: 4455-4465.

Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. Wang C, K Chua, W Seghezzi, E Lees, O Gozani and R Reed. 1998. Genes Dev 12: 1409-1414.

Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase. Zhang W, JR Bone, DG Edmondson, BM Turner and SY Roth. 1998. EMBO J 17: 3155-3167.

SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Zhang Y, ZW Sun, R Iratni, H Erdjument-Bromage, P Tempst, M Hampsey and D Reinberg. 1998. Mol Cell 1: 1021-1031.

A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site. Gozani O, J Potashkin and R Reed. 1998. Mol Cell Biol 18: 4752-4760.

Cyclin E associates with components of the pre-mRNA splicing machinery in mammalian cells. Seghezzi W, K Chua, F Shanahan, O Gozani, R Reed and E Lees. 1998. Mol Cell Biol 18: 4526-4536.

In vivo functions of histone acetylation/deacetylation in Tup1p repression and Gcn5p activation. Edmondson DG, W Zhang, A Watson, W Xu, JR Bone, Y Yu, D Stillman and SY Roth. 1998. Cold Spring Harb Symp Quant Biol 63: 459-468.

FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. Bedford MT, DC Chan and P Leder. 1997. EMBO J 16: 2376-2383.

Two proximal activating protein-1-binding sites are sufficient to stimulate transcription of the ovine follicle-stimulating hormone-beta gene. Strahl BD, HJ Huang, NR Pedersen, JC Wu, BR Ghosh and WL Miller. 1997. Endocrinology 138: 2621-2631.

High efficiency reporter gene transfection of vascular tissue in vitro and in vivo using a cationic lipid-DNA complex. Keogh MC, D Chen, F Lupu, N Shaper, JF Schmitt, VV Kakkar and NR Lemoine. 1997. Gene Ther 4: 162-171.

A function for CD2 on murine B cells?. Keogh MC, J Elliot, T Norton and RA Lake. 1997. Immunol Cell Biol 75: 333-339.

Dosage compensation regulatory proteins and the evolution of sex chromosomes in Drosophila. Bone JR and MI Kuroda. 1996. Genetics 144: 705-713.

Inhibin and estradiol alter gonadotropes differentially in ovine pituitary cultures: changing gonadotrope numbers and calcium responses to gonadotropin-releasing hormone. Ghosh BR, JC Wu, BD Strahl, GV Childs and WL Miller. 1996. Endocrinology 137: 5144-5154.

Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. Chan DC, MT Bedford and P Leder. 1996. EMBO J 15: 1045-1054.

RNA-dependent association of the Drosophila maleless protein with the male X chromosome. Richter L, JR Bone and MI Kuroda. 1996. Genes Cells 1: 325-336.

Functional interaction between TFIIB and the Rpb9 (Ssu73) subunit of RNA polymerase II in Saccharomyces cerevisiae. Sun ZW, A Tessmer and M Hampsey. 1996. Nucleic Acids Res 24: 2560-2566.

Identification of proteins that interact with exon sequences, splice sites, and the branchpoint sequence during each stage of spliceosome assembly. Chiara MD, O Gozani, M Bennett, P Champion-Arnaud, L Palandjian and R Reed. 1996. Mol Cell Biol 16: 3317-3326.

Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A. Gozani O, R Feld and R Reed. 1996. Genes Dev 10: 233-243.

Synthetic enhancement of a TFIIB defect by a mutation in SSU72, an essential yeast gene encoding a novel protein that affects transcription start site selection in vivo. Sun ZW and M Hampsey. 1996. Mol Cell Biol 16: 1557-1566.

Ectopic expression of Fgf-4 in chimeric mouse embryos induces the expression of early markers of limb development in the lateral ridge. Abud HE, JA Skinner, FJ McDonald, MT Bedford, P Lonai and JK Heath. 1996. Dev Genet 19: 51-65.

Accumulation of a novel spliceosomal complex on pre-mRNAs containing branch site mutations. Champion-Arnaud P, O Gozani, L Palandjian and R Reed. 1995. Mol Cell Biol 15: 5750-5756.

SSU71, encoding the largest subunit of TFIIF, is located on the right arm of chromosome VII in Saccharomyces cerevisiae. Sun ZW and M Hampsey. 1995. Yeast 11: 789-791.

Identification of the gene (SSU71/TFG1) encoding the largest subunit of transcription factor TFIIF as a suppressor of a TFIIB mutation in Saccharomyces cerevisiae. Sun ZW and M Hampsey. 1995. Proc Natl Acad Sci U S A 92: 3127-3131.

A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction. Gozani O, JG Patton and R Reed. 1994. EMBO J 13: 3356-3367.

Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila. Bone JR, J Lavender, R Richman, MJ Palmer, BM Turner and MI Kuroda. 1994. Genes Dev 8: 96-104.

Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Orr-Urtreger A, MT Bedford, T Burakova, E Arman, Y Zimmer, A Yayon, D Givol and P Lonai. 1993. Dev Biol 158: 475-486.

SpCOUP-TF: a sea urchin member of the steroid/thyroid hormone receptor family. Chan SM, N Xu, CC Niemeyer, JR Bone and CN Flytzanis. 1992. Proc Natl Acad Sci U S A 89: 10568-10572.

Developmental expression of the alpha receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation. Orr-Urtreger A, MT Bedford, MS Do, L Eisenbach and P Lonai. 1992. Development 115: 289-303.

Analysis of allele-specific methylation. Bedford MT and PD van Helden. 1990. Trends Genet 6: 140-141.

A method to analyze allele-specific methylation. Bedford MT and PD van Helden. 1990. Biotechniques 9: 744-748.

Hypomethylation of DNA in pathological conditions of the human prostate. Bedford MT and PD van Helden. 1987. Cancer Res 47: 5274-5276.