SETD2 Antibody Description: SETD2 (SET2, HYPB, HIF1, KMT3A, accession Q9BYW2, amino acids 1345-1711) is a SET-domain containing histone methyltransferase, catalyzing the trimethylation of histone H3 at lysine 36. SETD2 is a candidate tumor suppressor protein and mutated in clear cell renal cell carcinoma.
SETD2 Antibody Immunogen: Recombinant protein corresponding to amino acids amino acids 1345-1711 of human SETD2.
SETD2 Antibody Formulation: Immunoaffinity purified rabbit IgG in PBS (pH 7.4) with 0.02% sodium azide and 1% BSA.
Storage and Stability: Stable for 2 years at -20°C from date of receipt.
Western Blot Data: Western blot using SETD2 Antibody (1:500 dilution). Lane 1: Whole cell extract (50,000 whole cell equivalents) from HKC cells transformed with a random shRNA construct.
Lane 2: Whole cell extract (50,000 whole cell equivalents) from HKC cells transformed with construct stably expressing an shRNA targeting SETD2. (Click image to enlarge)