Regulation of Methyllysine Readers through Phosphorylation. Andrews FH, J Gatchalian, K Krajewski, BD Strahl and TG Kutateladze. 2016. ACS Chem Biol 11: 547-553.
The essential role of acetyllysine binding by the YEATS domain in transcriptional regulation. Andrews FH, EK Shanle, BD Strahl and TG Kutateladze. 2016. Transcription 7: 14-20.
The Taf14 YEATS domain is a reader of histone crotonylation. Andrews FH, SA Shinsky, EK Shanle, JB Bridgers, A Gest, IK Tsun, K Krajewski, X Shi, BD Strahl and TG Kutateladze. 2016. Nat Chem Biol 12: 396-398.
Epigenetic regulation of the histone-to-protamine transition during spermiogenesis. Bao J and MT Bedford. 2016. Reproduction 151: R55-70.
Quantitative Analysis of Dynamic Protein Interactions during Transcription Reveals a Role for Casein Kinase II in Polymerase-associated Factor (PAF) Complex Phosphorylation and Regulation of Histone H2B Monoubiquitylation. Bedard LG, R Dronamraju, JL Kerschner, GO Hunter, ED Axley, AK Boyd, BD Strahl and AL Mosley. 2016. J Biol Chem 291: 13410-13420.
Substrate Specificity Profiling of Histone-Modifying Enzymes by Peptide Microarray. Cornett EM, BM Dickson, RM Vaughan, S Krishnan, RC Trievel, BD Strahl and SB Rothbart. 2016. Methods Enzymol 574: 31-52.
Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Esteve PO, G Zhang, VK Ponnaluri, K Deepti, HG Chin, N Dai, C Sagum, K Black, IR Correa, Jr., MT Bedford, X Cheng and S Pradhan. 2016. Nucleic Acids Res 44: 1642-1656.
Chromatin condensation and recruitment of PHD finger proteins to histone H3K4me3 are mutually exclusive. Gatchalian J, CM Gallardo, SA Shinsky, RR Ospina, AM Liendo, K Krajewski, BJ Klein, FH Andrews, BD Strahl, MvW KH and TG Kutateladze. 2016. Nucleic Acids Res 44: 6102-6112.
Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs. Gayatri S, MW Cowles, V Vemulapalli, D Cheng, ZW Sun and MT Bedford. 2016. Sci Rep 6: 28718.
ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 to Regulate Budding. Han Z, CA Sagum, MT Bedford, SS Sidhu, M Sudol and RN Harty. 2016. J Virol
Antigen clasping by two antigen-binding sites of an exceptionally specific antibody for histone methylation. Hattori T, D Lai, IS Dementieva, SP Montano, K Kurosawa, Y Zheng, LR Akin, KM Swist-Rosowska, AT Grzybowski, A Koide, K Krajewski, BD Strahl, NL Kelleher, AJ Ruthenburg and S Koide. 2016. Proc Natl Acad Sci U S A 113: 2092-2097.
Structural Basis for the Unique Multivalent Readout of Unmodified H3 Tail by Arabidopsis ORC1b BAH-PHD Cassette. Li S, Z Yang, X Du, R Liu, AW Wilkinson, O Gozani, SE Jacobsen, DJ Patel and J Du. 2016. Structure 24: 486-494.
Combinatorial Histone Readout by the Dual Plant Homeodomain (PHD) Fingers of Rco1 Mediates Rpd3S Chromatin Recruitment and the Maintenance of Transcriptional Fidelity. McDaniel SL, JE Fligor, C Ruan, H Cui, JB Bridgers, JV DiFiore, AH Guo, B Li and BD Strahl. 2016. J Biol Chem 291: 14796-14802.
Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation. Metzger E, D Willmann, J McMillan, I Forne, P Metzger, S Gerhardt, K Petroll, A von Maessenhausen, S Urban, AK Schott, A Espejo, A Eberlin, D Wohlwend, KM Schule, M Schleicher, S Perner, MT Bedford, M Jung, J Dengjel, R Flaig, A Imhof, O Einsle and R Schule. 2016. Nat Struct Mol Biol 23: 132-139.
Coordination of stress signals by the lysine methyltransferase SMYD2 promotes pancreatic cancer. Reynoird N, PK Mazur, T Stellfeld, NM Flores, SM Lofgren, SM Carlson, E Brambilla, P Hainaut, EB Kaznowska, CH Arrowsmith, P Khatri, C Stresemann, O Gozani and J Sage. 2016. Genes Dev 30: 772-785.
A PWWP Domain of Histone-Lysine N-Methyltransferase NSD2 Binds to Dimethylated Lys-36 of Histone H3 and Regulates NSD2 Function at Chromatin. Sankaran SM, AW Wilkinson, JE Elias and O Gozani. 2016. J Biol Chem 291: 8465-8474.
A course-based undergraduate research experience investigating p300 bromodomain mutations. Shanle EK, IK Tsun and BD Strahl. 2016. Biochem Mol Biol Educ 44: 68-74.
Histone H3K36 methylation regulates pre-mRNA splicing in Saccharomyces cerevisiae. Sorenson MR, DK Jha, SA Ucles, DM Flood, BD Strahl, SW Stevens and TL Kress. 2016. RNA Biol 13: 412-426.
A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Stuckey JI, BM Dickson, N Cheng, Y Liu, JL Norris, SH Cholensky, W Tempel, S Qin, KG Huber, C Sagum, K Black, F Li, XP Huang, BL Roth, BM Baughman, G Senisterra, SG Pattenden, M Vedadi, PJ Brown, MT Bedford, J Min, CH Arrowsmith, LI James and SV Frye. 2016. Nat Chem Biol 12: 180-187.
Histone H4 Lysine 20 (H4K20) Methylation, Expanding the Signaling Potential of the Proteome One Methyl Moiety at a Time. van Nuland R and O Gozani. 2016. Mol Cell Proteomics 15: 755-764.
Light-induced nuclear export reveals rapid dynamics of epigenetic modifications. Yumerefendi H, AM Lerner, SP Zimmerman, K Hahn, JE Bear, BD Strahl and B Kuhlman. 2016. Nat Chem Biol 12: 399-401.
G9a-mediated methylation of ERalpha links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression. Zhang X, D Peng, Y Xi, C Yuan, CA Sagum, BJ Klein, K Tanaka, H Wen, TG Kutateladze, W Li, MT Bedford and X Shi. 2016. Nat Commun 7: 10810.
ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. Zhu L, Q Li, SH Wong, M Huang, BJ Klein, J Shen, L Ikenouye, M Onishi, D Schneidawind, C Buechele, L Hansen, J Duque-Afonso, F Zhu, GM Martin, O Gozani, R Majeti, TG Kutateladze and ML Cleary. 2016. Cancer Discov 6: 770-783.
Molecular Insights into Inhibition of the Methylated Histone-Plant Homeodomain Complexes by Calixarenes. Ali M, KD Daze, DE Strongin, SB Rothbart, H Rincon-Arano, HF Allen, J Li, BD Strahl, F Hof and TG Kutateladze. 2015. J Biol Chem 290: 22919-22930.
A Proteomic Strategy Identifies Lysine Methylation of Splicing Factor snRNP70 by the SETMAR Enzyme. Carlson SM, KE Moore, SM Sankaran, N Reynoird, JE Elias and O Gozani. 2015. J Biol Chem 290: 12040-12047.
The PZP Domain of AF10 Senses Unmodified H3K27 to Regulate DOT1L-Mediated Methylation of H3K79. Chen S, Z Yang, AW Wilkinson, AJ Deshpande, S Sidoli, K Krajewski, BD Strahl, BA Garcia, SA Armstrong, DJ Patel and O Gozani. 2015. Mol Cell 60: 319-327.
Neuronal Stress Pathway Mediating a Histone Methyl/Phospho Switch Is Required for Herpes Simplex Virus Reactivation. Cliffe AR, JH Arbuckle, JL Vogel, MJ Geden, SB Rothbart, CL Cusack, BD Strahl, TM Kristie and M Deshmukh. 2015. Cell Host Microbe 18: 649-658.
Product binding enforces the genomic specificity of a yeast polycomb repressive complex. Dumesic PA, CM Homer, JJ Moresco, LR Pack, EK Shanle, SM Coyle, BD Strahl, DG Fujimori, JR Yates, 3rd and HD Madhani. 2015. Cell 160: 204-218.
Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Esteve PO, G Zhang, VK Ponnaluri, K Deepti, HG Chin, N Dai, C Sagum, K Black, IR Correa, Jr., MT Bedford, X Cheng and S Pradhan. 2015. Nucleic Acids Res
Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. Hadjikyriacou A, Y Yang, A Espejo, MT Bedford and SG Clarke. 2015. J Biol Chem 290: 16723-16743.
Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus. Hu SB, JF Xiang, X Li, Y Xu, W Xue, M Huang, CC Wong, CA Sagum, MT Bedford, L Yang, D Cheng and LL Chen. 2015. Genes Dev 29: 630-645.
Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex. Kapoor P, Y Bao, J Xiao, A Espejo, L Yang, MT Bedford, G Peng and X Shen. 2015. Mol Cell 58: 863-869.
Interrogating the function of metazoan histones using engineered gene clusters. McKay DJ, S Klusza, TJ Penke, MP Meers, KP Curry, SL McDaniel, PY Malek, SW Cooper, DC Tatomer, JD Lieb, BD Strahl, RJ Duronio and AG Matera. 2015. Dev Cell 32: 373-386.
Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene. Perez CJ, L Mecklenburg, J Jaubert, L Martinez-Santamaria, BM Iritani, A Espejo, E Napoli, G Song, M del Rio, J DiGiovanni, C Giulivi, MT Bedford, SY Dent, RD Wood, DF Kusewitt, JL Guenet, CJ Conti and F Benavides. 2015. J Invest Dermatol 135: 3133-3143.
Identification of a fragment-like small molecule ligand for the methyl-lysine binding protein, 53BP1. Perfetti MT, BM Baughman, BM Dickson, Y Mu, G Cui, P Mader, A Dong, JL Norris, SB Rothbart, BD Strahl, PJ Brown, WP Janzen, CH Arrowsmith, G Mer, KM McBride, LI James and SV Frye. 2015. ACS Chem Biol 10: 1072-1081.
An Interactive Database for the Assessment of Histone Antibody Specificity. Rothbart SB, BM Dickson, JR Raab, AT Grzybowski, K Krajewski, AH Guo, EK Shanle, SZ Josefowicz, SM Fuchs, CD Allis, TR Magnuson, AJ Ruthenburg and BD Strahl. 2015. Mol Cell 59: 502-511.
From histones to ribosomes: a chromatin regulator tangoes with translation. Rothbart SB, BM Dickson and BD Strahl. 2015. Cancer Discov 5: 228-230.
Coactivator-Associated Arginine Methyltransferase-1 Function in Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility. Sarker RS, G John-Schuster, A Bohla, K Mutze, G Burgstaller, MT Bedford, M Konigshoff, O Eickelberg and AO Yildirim. 2015. Am J Respir Cell Mol Biol 53: 769-781.
Association of Taf14 with acetylated histone H3 directs gene transcription and the DNA damage response. Shanle EK, FH Andrews, H Meriesh, SL McDaniel, R Dronamraju, JV DiFiore, D Jha, GG Wozniak, JB Bridgers, JL Kerschner, K Krajewski, GM Martin, AJ Morrison, TG Kutateladze and BD Strahl. 2015. Genes Dev 29: 1795-1800.
A course-based undergraduate research experience investigating p300 bromodomain mutations. Shanle EK, IK Tsun and BD Strahl. 2016. Biochem Mol Biol Educ 44: 68-74.
A Role for Widely Interspaced Zinc Finger (WIZ) in Retention of the G9a Methyltransferase on Chromatin. Simon JM, JS Parker, F Liu, SB Rothbart, S Ait-Si-Ali, BD Strahl, J Jin, IJ Davis, AL Mosley and SG Pattenden. 2015. J Biol Chem 290: 26088-26102.
Structural plasticity of methyllysine recognition by the tandem tudor domain of 53BP1. Tong Q, G Cui, MV Botuyan, SB Rothbart, R Hayashi, CA Musselman, N Singh, E Appella, BD Strahl, G Mer and TG Kutateladze. 2015. Structure 23: 312-321.
An acetyl-methyl switch drives a conformational change in p53. Tong Q, SJ Mazur, H Rincon-Arano, SB Rothbart, DM Kuznetsov, G Cui, WH Liu, Y Gete, BJ Klein, L Jenkins, G Mer, AG Kutateladze, BD Strahl, M Groudine, E Appella and TG Kutateladze. 2015. Structure 23: 322-331.
H4K20 methylation: expanding the signaling potential of the proteome one methyl moiety at a time. van Nuland R and O Gozani. 2015. Mol Cell Proteomics
Non-canonical Bromodomain within DNA-PKcs Promotes DNA Damage Response and Radioresistance through Recognizing an IR-Induced Acetyl-Lysine on H2AX. Wang L, L Xie, S Ramachandran, Y Lee, Z Yan, L Zhou, K Krajewski, F Liu, C Zhu, DJ Chen, BD Strahl, J Jin, NV Dokholyan and X Chen. 2015. Chem Biol 22: 849-861.
PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Yang Y, A Hadjikyriacou, Z Xia, S Gayatri, D Kim, C Zurita-Lopez, R Kelly, A Guo, W Li, SG Clarke and MT Bedford. 2015. Nat Commun 6: 6428.
A Meier-Gorlin syndrome mutation impairs the ORC1-nucleosome association. Zhang W, S Sankaran, O Gozani and J Song. 2015. ACS Chem Biol 10: 1176-1180.
An Allosteric Interaction Links USP7 to Deubiquitination and Chromatin Targeting of UHRF1. Zhang ZM, SB Rothbart, DF Allison, Q Cai, JS Harrison, L Li, Y Wang, BD Strahl, GG Wang and J Song. 2015. Cell Rep 12: 1400-1406.
Drosophila TAP/p32 is a core histone chaperone that cooperates with NAP-1, NLP, and nucleophosmin in sperm chromatin remodeling during fertilization. Emelyanov AV, J Rabbani, M Mehta, E Vershilova, MC Keogh and DV Fyodorov. 2014. Genes Dev 28: 2027-2040.
Emerging technologies to map the protein methylome. Carlson SM and O Gozani. 2014. J Mol Biol 426: 3350-3362.
A PWWP domain-containing protein targets the NuA3 acetyltransferase complex via histone H3 lysine 36 trimethylation to coordinate transcriptional elongation at coding regions. Gilbert TM, SL McDaniel, SD Byrum, JA Cades, BC Dancy, H Wade, AJ Tackett, BD Strahl and SD Taverna. 2014. Mol Cell Proteomics 13: 2883-2895.
Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation. Esteve PO, J Terragni, K Deepti, HG Chin, N Dai, A Espejo, IR Correa, Jr., MT Bedford and S Pradhan. 2014. J Biol Chem 289: 8277-8287.
Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function. Kim HS, R Mukhopadhyay, SB Rothbart, AC Silva, V Vanoosthuyse, E Radovani, T Kislinger, A Roguev, CJ Ryan, J Xu, H Jahari, KG Hardwick, JF Greenblatt, NJ Krogan, JS Fillingham, BD Strahl, EE Bouhassira, W Edelmann and MC Keogh. 2014. Cell Rep 6: 892-905.
Nuclear PI5P, Uhrf1, and the road not taken. Reynoird N and O Gozani. 2014. Mol Cell 54: 901-903.
SMYD3 links lysine methylation of MAP3K2 to Ras-driven cancer. Mazur PK, N Reynoird, P Khatri, PW Jansen, AW Wilkinson, S Liu, O Barbash, GS Van Aller, M Huddleston, D Dhanak, PJ Tummino, RG Kruger, BA Garcia, AJ Butte, M Vermeulen, J Sage and O Gozani. 2014. Nature 510: 283-287.
A gain-of-function mouse model identifies PRMT6 as a NF-kappaB coactivator. Di Lorenzo A, Y Yang, M Macaluso and MT Bedford. 2014. Nucleic Acids Res 42: 8297-8309.
The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. Klein BJ, L Piao, Y Xi, H Rincon-Arano, SB Rothbart, D Peng, H Wen, C Larson, X Zhang, X Zheng, MA Cortazar, PV Pena, A Mangan, DL Bentley, BD Strahl, M Groudine, W Li, X Shi and TG Kutateladze. 2014. Cell Rep 6: 325-335.
Proteome-wide enrichment of proteins modified by lysine methylation. Carlson SM, KE Moore, EM Green, GM Martin and O Gozani. 2014. Nat Protoc 9: 37-50.
A feed forward circuit comprising Spt6, Ctk1 and PAF regulates Pol II CTD phosphorylation and transcription elongation. Dronamraju R and BD Strahl. 2014. Nucleic Acids Res 42: 870-881.
Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Guo A, H Gu, J Zhou, D Mulhern, Y Wang, KA Lee, V Yang, M Aguiar, J Kornhauser, X Jia, J Ren, SA Beausoleil, JC Silva, V Vemulapalli, MT Bedford and MJ Comb. 2014. Mol Cell Proteomics 13: 372-387.
Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Yang Y, KM McBride, S Hensley, Y Lu, F Chedin and MT Bedford. 2014. Mol Cell 53: 484-497.
Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase in osteoclasts. Levy-Apter E, E Finkelshtein, V Vemulapalli, SS Li, MT Bedford and A Elson. 2014. J Biol Chem 289: 36048-36058.
An unexpected journey: lysine methylation across the proteome. Moore KE and O Gozani. 2014. Biochim Biophys Acta 1839: 1395-1403.
Hitting the 'mark': interpreting lysine methylation in the context of active transcription. Wozniak GG and BD Strahl. 2014. Biochim Biophys Acta 1839: 1353-1361.
A molecular threading mechanism underlies Jumonji lysine demethylase KDM2A regulation of methylated H3K36. Cheng Z, P Cheung, AJ Kuo, ET Yukl, CM Wilmot, O Gozani and DJ Patel. 2014. Genes Dev 28: 1758-1771.
Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor. Carr SM, S Munro, LP Zalmas, O Fedorov, C Johansson, T Krojer, CA Sagum, MT Bedford, U Oppermann and NB La Thangue. 2014. Proc Natl Acad Sci U S A 111: 11341-11346.
Catalysis-dependent stabilization of Bre1 fine-tunes histone H2B ubiquitylation to regulate gene transcription. Wozniak GG and BD Strahl. 2014. Genes Dev 28: 1647-1652.
Readers of histone methylarginine marks. Gayatri S and MT Bedford. 2014. Biochim Biophys Acta 1839: 702-710.
SET-ting the stage for DNA repair. Jha DK, SX Pfister, TC Humphrey and BD Strahl. 2014. Nat Struct Mol Biol 21: 655-657.
Interpreting the language of histone and DNA modifications. Rothbart SB and BD Strahl. 2014. Biochim Biophys Acta 1839: 627-643.
Chromatin biochemistry enters the next generation of code 'seq-ing'. Shanle EK, SB Rothbart and BD Strahl. 2014. Nat Methods 11: 799-800.
Histone-binding domains: strategies for discovery and characterization. Wilkinson AW and O Gozani. 2014. Biochim Biophys Acta 1839: 669-675.
A histone methylation network regulates transgenerational epigenetic memory in C. elegans. Greer EL, SE Beese-Sims, E Brookes, R Spadafora, Y Zhu, SB Rothbart, D Aristizabal-Corrales, S Chen, AI Badeaux, Q Jin, W Wang, BD Strahl, MP Colaiacovo and Y Shi. 2014. Cell Rep 7: 113-126.
Set5 and Set1 cooperate to repress gene expression at telomeres and retrotransposons. Martin GM, DA King, EM Green, PE Garcia-Nieto, R Alexander, SR Collins, NJ Krogan, OP Gozani and AJ Morrison. 2014. Epigenetics 9: 513-522.
An RNA polymerase II-coupled function for histone H3K36 methylation in checkpoint activation and DSB repair. Jha DK and BD Strahl. 2014. Nat Commun 5: 3965.
Evolutionarily conserved genetic interactions with budding and fission yeast MutS identify orthologous relationships in mismatch repair-deficient cancer cells. Tosti E, JA Katakowski, S Schaetzlein, HS Kim, CJ Ryan, M Shales, A Roguev, NJ Krogan, D Palliser, MC Keogh and W Edelmann. 2014. Genome Med 6: 68.
Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue. Kinkelin K, GG Wozniak, SB Rothbart, M Lidschreiber, BD Strahl and P Cramer. 2013. Proc Natl Acad Sci U S A 110: 15277-15282.
Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Zheng S, J Moehlenbrink, YC Lu, LP Zalmas, CA Sagum, S Carr, JF McGouran, L Alexander, O Fedorov, S Munro, B Kessler, MT Bedford, Q Yu and NB La Thangue. 2013. Mol Cell 52: 37-51.
Recombinant antibodies to histone post-translational modifications. Hattori T, JM Taft, KM Swist, H Luo, H Witt, M Slattery, A Koide, AJ Ruthenburg, K Krajewski, BD Strahl, KP White, PJ Farnham, Y Zhao and S Koide. 2013. Nat Methods 10: 992-995.
Stress-free with Rpd3: a unique chromatin complex mediates the response to oxidative stress. McDaniel SL and BD Strahl. 2013. Mol Cell Biol 33: 3726-3727.
A TR-FRET-based functional assay for screening activators of CARM1. Zeng H, J Wu, MT Bedford, G Sbardella, FM Hoffmann, K Bi and W Xu. 2013. Chembiochem 14: 827-835.
A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. Moore KE, SM Carlson, ND Camp, P Cheung, RG James, KF Chua, A Wolf-Yadlin and O Gozani. 2013. Mol Cell 50: 444-456.
The carboxyl terminus of Rtt109 functions in chaperone control of histone acetylation. Radovani E, M Cadorin, T Shams, S El-Rass, AR Karsou, HS Kim, CF Kurat, MC Keogh, JF Greenblatt and JS Fillingham. 2013. Eukaryot Cell 12: 654-664.
Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. James LI, D Barsyte-Lovejoy, N Zhong, L Krichevsky, VK Korboukh, JM Herold, CJ MacNevin, JL Norris, CA Sagum, W Tempel, E Marcon, H Guo, C Gao, XP Huang, S Duan, A Emili, JF Greenblatt, DB Kireev, J Jin, WP Janzen, PJ Brown, MT Bedford, CH Arrowsmith and SV Frye. 2013. Nat Chem Biol 9: 184-191.
Polymerase IV occupancy at RNA-directed DNA methylation sites requires SHH1. Law JA, J Du, CJ Hale, S Feng, K Krajewski, AM Palanca, BD Strahl, DJ Patel and SE Jacobsen. 2013. Nature 498: 385-389.
Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation. Rothbart SB, BM Dickson, MS Ong, K Krajewski, S Houliston, DB Kireev, CH Arrowsmith and BD Strahl. 2013. Genes Dev 27: 1288-1298.
Dido3 PHD modulates cell differentiation and division. Gatchalian J, A Futterer, SB Rothbart, Q Tong, H Rincon-Arano, A Sanchez de Diego, M Groudine, BD Strahl, AC Martinez, KH van Wely and TG Kutateladze. 2013. Cell Rep 4: 148-158.
Molecular basis for chromatin binding and regulation of MLL5. Ali M, H Rincon-Arano, W Zhao, SB Rothbart, Q Tong, SM Parkhurst, BD Strahl, LW Deng, M Groudine and TG Kutateladze. 2013. Proc Natl Acad Sci U S A 110: 11296-11301.
Chd5 requires PHD-mediated histone 3 binding for tumor suppression. Paul S, A Kuo, T Schalch, H Vogel, L Joshua-Tor, WR McCombie, O Gozani, M Hammell and AA Mills. 2013. Cell Rep 3: 92-102.
Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. Li J, Z Zhao, C Carter, LI Ehrlich, MT Bedford and ER Richie. 2013. J Immunol 190: 597-604.
Protein arginine methyltransferases and cancer. Yang Y and MT Bedford. 2013. Nat Rev Cancer 13: 37-50.
An H3K36 methylation-engaging Tudor motif of polycomb-like proteins mediates PRC2 complex targeting. Cai L, SB Rothbart, R Lu, B Xu, WY Chen, A Tripathy, S Rockowitz, D Zheng, DJ Patel, CD Allis, BD Strahl, J Song and GG Wang. 2013. Mol Cell 49: 571-582.
Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions. Feng Y, R Maity, JP Whitelegge, A Hadjikyriacou, Z Li, C Zurita-Lopez, Q Al-Hadid, AT Clark, MT Bedford, JY Masson and SG Clarke. 2013. J Biol Chem 288: 37010-37025.
Nuclear phosphatidylinositol-5-phosphate regulates ING2 stability at discrete chromatin targets in response to DNA damage. Bua DJ, GM Martin, O Binda and O Gozani. 2013. Sci Rep 3: 2137.
Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Dhar S, V Vemulapalli, AN Patananan, GL Huang, A Di Lorenzo, S Richard, MJ Comb, A Guo, SG Clarke and MT Bedford. 2013. Sci Rep 3: 1311.
Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Kawabe Y, YX Wang, IW McKinnell, MT Bedford and MA Rudnicki. 2012. Cell Stem Cell 11: 333-345.
Long noncoding RNAs are rarely translated in two human cell lines. Banfai B, H Jia, J Khatun, E Wood, B Risk, WE Gundling, Jr., A Kundaje, HP Gunawardena, Y Yu, L Xie, K Krajewski, BD Strahl, X Chen, P Bickel, MC Giddings, JB Brown and L Lipovich. 2012. Genome Res 22: 1646-1657.
PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Cui G, S Park, AI Badeaux, D Kim, J Lee, JR Thompson, F Yan, S Kaneko, Z Yuan, MV Botuyan, MT Bedford, JQ Cheng and G Mer. 2012. Nat Struct Mol Biol 19: 916-924.
On silico peptide microarrays for high-resolution mapping of antibody epitopes and diverse protein-protein interactions. Price JV, S Tangsombatvisit, G Xu, J Yu, D Levy, EC Baechler, O Gozani, M Varma, PJ Utz and CL Liu. 2012. Nat Med 18: 1434-1440.
DNA replication origin function is promoted by H3K4 di-methylation in Saccharomyces cerevisiae. Rizzardi LF, ES Dorn, BD Strahl and JG Cook. 2012. Genetics 192: 371-384.
Titivated for destruction: the methyl degron. Yang Y and MT Bedford. 2012. Mol Cell 48: 487-488.
Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1. Castellano S, A Spannhoff, C Milite, F Dal Piaz, D Cheng, A Tosco, M Viviano, A Yamani, A Cianciulli, M Sala, V Cura, J Cavarelli, E Novellino, A Mai, MT Bedford and G Sbardella. 2012. J Med Chem 55: 9875-9890.
Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Rothbart SB, K Krajewski, N Nady, W Tempel, S Xue, AI Badeaux, D Barsyte-Lovejoy, JY Martinez, MT Bedford, SM Fuchs, CH Arrowsmith and BD Strahl. 2012. Nat Struct Mol Biol 19: 1155-1160.
Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses. Green EM, G Mas, NL Young, BA Garcia and O Gozani. 2012. Nat Struct Mol Biol 19: 361-363.
Hierarchical modularity and the evolution of genetic interactomes across species. Ryan CJ, A Roguev, K Patrick, J Xu, H Jahari, Z Tong, P Beltrao, M Shales, H Qu, SR Collins, JI Kliegman, L Jiang, D Kuo, E Tosti, HS Kim, W Edelmann, MC Keogh, D Greene, C Tang, P Cunningham, KM Shokat, G Cagney, JP Svensson, C Guthrie, PJ Espenshade, T Ideker and NJ Krogan. 2012. Mol Cell 46: 691-704.
SIRT7 links H3K18 deacetylation to maintenance of oncogenic transformation. Barber MF, E Michishita-Kioi, Y Xi, L Tasselli, M Kioi, Z Moqtaderi, RI Tennen, S Paredes, NL Young, K Chen, K Struhl, BA Garcia, O Gozani, W Li and KF Chua. 2012. Nature 487: 114-118.
New marks on the block: Set5 methylates H4 lysines 5, 8 and 12. Green EM, AJ Morrison and O Gozani. 2012. Nucleus 3: 335-339.
Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Calnan DR, AE Webb, JL White, TR Stowe, T Goswami, X Shi, A Espejo, MT Bedford, O Gozani, SP Gygi and A Brunet. 2012. Aging (Albany NY) 4: 462-479.
RNA polymerase II carboxyl-terminal domain phosphorylation regulates protein stability of the Set2 methyltransferase and histone H3 di- and trimethylation at lysine 36. Fuchs SM, KO Kizer, H Braberg, NJ Krogan and BD Strahl. 2012. J Biol Chem 287: 3249-3256.
The replication-independent histone H3-H4 chaperones HIR, ASF1, and RTT106 co-operate to maintain promoter fidelity. Silva AC, X Xu, HS Kim, J Fillingham, T Kislinger, TA Mennella and MC Keogh. 2012. J Biol Chem 287: 1709-1718.
Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. Badeaux AI, Y Yang, K Cardenas, V Vemulapalli, K Chen, D Kusewitt, E Richie, W Li and MT Bedford. 2012. J Biol Chem 287: 429-437.
Everybody's welcome: The big tent approach to epigenetic drug discovery. Green EM and O Gozani. 2012. Drug Discov Today Ther Strateg 9: e75-e81.
Tandem PHD fingers of MORF/MOZ acetyltransferases display selectivity for acetylated histone H3 and are required for the association with chromatin. Ali M, K Yan, ME Lalonde, C Degerny, SB Rothbart, BD Strahl, J Cote, XJ Yang and TG Kutateladze. 2012. J Mol Biol 424: 328-338.
Broad ranges of affinity and specificity of anti-histone antibodies revealed by a quantitative peptide immunoprecipitation assay. Nishikori S, T Hattori, SM Fuchs, N Yasui, J Wojcik, A Koide, BD Strahl and S Koide. 2012. J Mol Biol 424: 391-399.
Phf19 links methylated Lys36 of histone H3 to regulation of Polycomb activity. Ballare C, M Lange, A Lapinaite, GM Martin, L Morey, G Pascual, R Liefke, B Simon, Y Shi, O Gozani, T Carlomagno, SA Benitah and L Di Croce. 2012. Nat Struct Mol Biol 19: 1257-1265.
Targeted silencing of the oncogenic transcription factor SOX2 in breast cancer. Stolzenburg S, MG Rots, AS Beltran, AG Rivenbark, X Yuan, H Qian, BD Strahl and P Blancafort. 2012. Nucleic Acids Res 40: 6725-6740.
The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Kuo AJ, J Song, P Cheung, S Ishibe-Murakami, S Yamazoe, JK Chen, DJ Patel and O Gozani. 2012. Nature 484: 115-119.
Epigenetic reprogramming of cancer cells via targeted DNA methylation. Rivenbark AG, S Stolzenburg, AS Beltran, X Yuan, MG Rots, BD Strahl and P Blancafort. 2012. Epigenetics 7: 350-360.
Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Van Aller GS, N Reynoird, O Barbash, M Huddleston, S Liu, AF Zmoos, P McDevitt, R Sinnamon, B Le, G Mas, R Annan, J Sage, BA Garcia, PJ Tummino, O Gozani and RG Kruger. 2012. Epigenetics 7: 340-343.
Methods applied to the study of protein arginine methylation. Cheng D, V Vemulapalli and MT Bedford. 2012. Methods Enzymol 512: 71-92.
Specific post-translational histone modifications of neutrophil extracellular traps as immunogens and potential targets of lupus autoantibodies. Liu CL, S Tangsombatvisit, JM Rosenberg, G Mandelbaum, EC Gillespie, OP Gozani, AA Alizadeh and PJ Utz. 2012. Arthritis Res Ther 14: R25.
Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30. Liu K, Y Guo, H Liu, C Bian, R Lam, Y Liu, F Mackenzie, LA Rojas, D Reinberg, MT Bedford, RM Xu and J Min. 2012. PLoS One 7: e30375.
Peptide microarrays to interrogate the "histone code". Rothbart SB, K Krajewski, BD Strahl and SM Fuchs. 2012. Methods Enzymol 512: 107-135.
Poly-acetylated chromatin signatures are preferred epitopes for site-specific histone H4 acetyl antibodies. Rothbart SB, S Lin, LM Britton, K Krajewski, MC Keogh, BA Garcia and BD Strahl. 2012. Sci Rep 2: 489.
Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. Zhao H, PC Ho, YH Lo, A Espejo, MT Bedford, MC Hung and SC Wang. 2012. PLoS One 7: e29416.
NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Kuo AJ, P Cheung, K Chen, BM Zee, M Kioi, J Lauring, Y Xi, BH Park, X Shi, BA Garcia, W Li and O Gozani. 2011. Mol Cell 44: 609-620.
Operating on chromatin, a colorful language where context matters. Gardner KE, CD Allis and BD Strahl. 2011. J Mol Biol 409: 36-46.
Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. Chang Y, JR Horton, MT Bedford, X Zhang and X Cheng. 2011. J Mol Biol 408: 807-814.
Methylation by protein arginine methyltransferase 1 increases stability of Axin, a negative regulator of Wnt signaling. Cha B, W Kim, YK Kim, BN Hwang, SY Park, JW Yoon, WS Park, JW Cho, MT Bedford and EH Jho. 2011. Oncogene 30: 2379-2389.
Regulation of histone H2A and H2B deubiquitination and Xenopus development by USP12 and USP46. Joo HY, A Jones, C Yang, L Zhai, ADt Smith, Z Zhang, MB Chandrasekharan, ZW Sun, MB Renfrow, Y Wang, C Chang and H Wang. 2011. J Biol Chem 286: 7190-7201.
Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. Spannhoff A, YK Kim, NJ Raynal, V Gharibyan, MB Su, YY Zhou, J Li, S Castellano, G Sbardella, JP Issa and MT Bedford. 2011. EMBO Rep 12: 238-243.
Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bissinger EM, R Heinke, A Spannhoff, A Eberlin, E Metzger, V Cura, P Hassenboehler, J Cavarelli, R Schule, MT Bedford, W Sippl and M Jung. 2011. Bioorg Med Chem 19: 3717-3731.
Antibody recognition of histone post-translational modifications: emerging issues and future prospects. Fuchs SM and BD Strahl. 2011. Epigenomics 3: 247-249.
Regulation of p53 function by lysine methylation. West LE and O Gozani. 2011. Epigenomics 3: 361-369.
Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. Cheng D, S Valente, S Castellano, G Sbardella, R Di Santo, R Costi, MT Bedford and A Mai. 2011. J Med Chem 54: 4928-4932.
Histone arginine methylation. Di Lorenzo A and MT Bedford. 2011. FEBS Lett 585: 2024-2031.
Decoding the trans-histone crosstalk: methods to analyze H2B ubiquitination, H3 methylation and their regulatory factors. Chandrasekharan MB, F Huang and ZW Sun. 2011. Methods 54: 304-314.
Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. Guo Q, MT Bedford and W Fast. 2011. Mol Biosyst 7: 2286-2295.
A chemical method for labeling lysine methyltransferase substrates. Binda O, M Boyce, JS Rush, KK Palaniappan, CR Bertozzi and O Gozani. 2011. Chembiochem 12: 330-334.
Xenoestrogens regulate the activity of arginine methyltransferases. Cheng D and MT Bedford. 2011. Chembiochem 12: 323-329.
Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Lee YH, MT Bedford and MR Stallcup. 2011. Genes Dev 25: 176-188.
Influence of combinatorial histone modifications on antibody and effector protein recognition. Fuchs SM, K Krajewski, RW Baker, VL Miller and BD Strahl. 2011. Curr Biol 21: 53-58.
Lysine methylation of the NF-kappaB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-kappaB signaling. Levy D, AJ Kuo, Y Chang, U Schaefer, C Kitson, P Cheung, A Espejo, BM Zee, CL Liu, S Tangsombatvisit, RI Tennen, AY Kuo, S Tanjing, R Cheung, KF Chua, PJ Utz, X Shi, RK Prinjha, K Lee, BA Garcia, MT Bedford, A Tarakhovsky, X Cheng and O Gozani. 2011. Nat Immunol 12: 29-36.
Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Woolard J, W Vousden, SJ Moss, A Krishnakumar, MV Gammons, DG Nowak, N Dixon, J Micklefield, A Spannhoff, MT Bedford, MA Gregory, CJ Martin, PF Leadlay, MQ Zhang, SJ Harper, DO Bates and B Wilkinson. 2011. Chem Sci 2011: 273-278.
Crosstalk between Arg 1175 methylation and Tyr 1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Hsu JM, CT Chen, CK Chou, HP Kuo, LY Li, CY Lin, HJ Lee, YN Wang, M Liu, HW Liao, B Shi, CC Lai, MT Bedford, CH Tsai and MC Hung. 2011. Nat Cell Biol 13: 174-181.
Hypoxia-induced methylation of a pontin chromatin remodeling factor. Lee JS, Y Kim, J Bhin, HJ Shin, HJ Nam, SH Lee, JB Yoon, O Binda, O Gozani, D Hwang and SH Baek. 2011. Proc Natl Acad Sci U S A 108: 13510-13515.
CUL4B: trash talking at chromatin. Green EM and O Gozani. 2011. Mol Cell 43: 321-323.
Structural basis of SETD6-mediated regulation of the NF-kB network via methyl-lysine signaling. Chang Y, D Levy, JR Horton, J Peng, X Zhang, O Gozani and X Cheng. 2011. Nucleic Acids Res 39: 6380-6389.
Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. Butler JS, CI Zurita-Lopez, SG Clarke, MT Bedford and SY Dent. 2011. J Biol Chem 286: 12234-12244.
MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Chang Y, L Sun, K Kokura, JR Horton, M Fukuda, A Espejo, V Izumi, JM Koomen, MT Bedford, X Zhang, Y Shinkai, J Fang and X Cheng. 2011. Nat Commun 2: 533.
Identification of lysine 37 of histone H2B as a novel site of methylation. Gardner KE, L Zhou, MA Parra, X Chen and BD Strahl. 2011. PLoS One 6: e16244.
The Ccr4-Not complex interacts with the mRNA export machinery. Kerr SC, N Azzouz, SM Fuchs, MA Collart, BD Strahl, AH Corbett and RN Laribee. 2011. PLoS One 6: e18302.
A proteomic approach for the identification of novel lysine methyltransferase substrates. Levy D, CL Liu, Z Yang, AM Newman, AA Alizadeh, PJ Utz and O Gozani. 2011. Epigenetics Chromatin 4: 19.
Thermodynamic stability of histone H3 is a necessary but not sufficient driving force for its evolutionary conservation. Ramachandran S, L Vogel, BD Strahl and NV Dokholyan. 2011. PLoS Comput Biol 7: e1001042.
Decoding chromatin goes high tech. Levy D and O Gozani. 2010. Cell 142: 844-846.
Trimethylation of histone H3 lysine 4 impairs methylation of histone H3 lysine 9: regulation of lysine methyltransferases by physical interaction with their substrates. Binda O, G LeRoy, DJ Bua, BA Garcia, O Gozani and S Richard. 2010. Epigenetics 5: 767-775.
Methylation of the retinoblastoma tumor suppressor by SMYD2. Saddic LA, LE West, A Aslanian, JR Yates, 3rd, SM Rubin, O Gozani and J Sage. 2010. J Biol Chem 285: 37733-37740.
The MBT repeats of L3MBTL1 link SET8-mediated p53 methylation at lysine 382 to target gene repression. West LE, S Roy, K Lachmi-Weiner, R Hayashi, X Shi, E Appella, TG Kutateladze and O Gozani. 2010. J Biol Chem 285: 37725-37732.
Hdac3 is essential for the maintenance of chromatin structure and genome stability. Bhaskara S, SK Knutson, G Jiang, MB Chandrasekharan, AJ Wilson, S Zheng, A Yenamandra, K Locke, JL Yuan, AR Bonine-Summers, CE Wells, JF Kaiser, MK Washington, Z Zhao, FF Wagner, ZW Sun, F Xia, EB Holson, D Khabele and SW Hiebert. 2010. Cancer Cell 18: 436-447.
Systematic identification of methyllysine-driven interactions for histone and nonhistone targets. Liu H, M Galka, A Iberg, Z Wang, L Li, C Voss, X Jiang, G Lajoie, Z Huang, MT Bedford and SS Li. 2010. J Proteome Res 9: 5827-5836.
Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. Kokura K, L Sun, MT Bedford and J Fang. 2010. EMBO J 29: 3673-3687.
Structural insight into p53 recognition by the 53BP1 tandem Tudor domain. Roy S, CA Musselman, I Kachirskaia, R Hayashi, KC Glass, JC Nix, O Gozani, E Appella and TG Kutateladze. 2010. J Mol Biol 398: 489-496.
Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Bredfeldt TG, KL Greathouse, SH Safe, MC Hung, MT Bedford and CL Walker. 2010. Mol Endocrinol 24: 993-1006.
AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Short JD, R Dere, KD Houston, SL Cai, J Kim, JM Bergeron, J Shen, J Liang, MT Bedford, GB Mills and CL Walker. 2010. Mol Carcinog 49: 429-439.
Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). Castellano S, C Milite, R Ragno, S Simeoni, A Mai, V Limongelli, E Novellino, I Bauer, G Brosch, A Spannhoff, D Cheng, MT Bedford and G Sbardella. 2010. ChemMedChem 5: 398-414.
Members of the H3K4 trimethylation complex regulate lifespan in a germline-dependent manner in C. elegans. Greer EL, TJ Maures, AG Hauswirth, EM Green, DS Leeman, GS Maro, S Han, MR Banko, O Gozani and A Brunet. 2010. Nature 466: 383-387.
Mouse models for the p53 R72P polymorphism mimic human phenotypes. Zhu F, ME Dolle, TR Berton, RV Kuiper, C Capps, A Espejo, MJ McArthur, MT Bedford, H van Steeg, A de Vries and DG Johnson. 2010. Cancer Res 70: 5851-5859.
Binding of the MLL PHD3 finger to histone H3K4me3 is required for MLL-dependent gene transcription. Chang PY, RA Hom, CA Musselman, L Zhu, A Kuo, O Gozani, TG Kutateladze and ML Cleary. 2010. J Mol Biol 400: 137-144.
Molecular mechanism of MLL PHD3 and RNA recognition by the Cyp33 RRM domain. Hom RA, PY Chang, S Roy, CA Musselman, KC Glass, AI Selezneva, O Gozani, RF Ismagilov, ML Cleary and TG Kutateladze. 2010. J Mol Biol 400: 145-154.
Negative regulation of hypoxic responses via induced Reptin methylation. Lee JS, Y Kim, IS Kim, B Kim, HJ Choi, JM Lee, HJ Shin, JH Kim, JY Kim, SB Seo, H Lee, O Binda, O Gozani, GL Semenza, M Kim, KI Kim, D Hwang and SH Baek. 2010. Mol Cell 39: 71-85.
Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. Chang Y, T Ganesh, JR Horton, A Spannhoff, J Liu, A Sun, X Zhang, MT Bedford, Y Shinkai, JP Snyder and X Cheng. 2010. J Mol Biol 400: 1-7.
Histone H2B C-terminal helix mediates trans-histone H3K4 methylation independent of H2B ubiquitination. Chandrasekharan MB, F Huang, YC Chen and ZW Sun. 2010. Mol Cell Biol 30: 3216-3232.
CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. O'Brien KB, M Alberich-Jorda, N Yadav, O Kocher, A Diruscio, A Ebralidze, E Levantini, NJ Sng, M Bhasin, T Caron, D Kim, U Steidl, G Huang, B Halmos, SJ Rodig, MT Bedford, DG Tenen and S Kobayashi. 2010. Development 137: 2147-2156.
Enzymatic activity is required for the in vivo functions of CARM1. Kim D, J Lee, D Cheng, J Li, C Carter, E Richie and MT Bedford. 2010. J Biol Chem 285: 1147-1152.
A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Quinn AM, MT Bedford, A Espejo, A Spannhoff, CP Austin, U Oppermann and A Simeonov. 2010. Nucleic Acids Res 38: e11.
TDRD3 is an effector molecule for arginine-methylated histone marks. Yang Y, Y Lu, A Espejo, J Wu, W Xu, S Liang and MT Bedford. 2010. Mol Cell 40: 1016-1023.
Individual lysine acetylations on the N terminus of Saccharomyces cerevisiae H2A.Z are highly but not differentially regulated. Mehta M, H Braberg, S Wang, A Lozsa, M Shales, A Solache, NJ Krogan and MC Keogh. 2010. J Biol Chem 285: 39855-39865.
TRIM24 links a non-canonical histone signature to breast cancer. Tsai WW, Z Wang, TT Yiu, KC Akdemir, W Xia, S Winter, CY Tsai, X Shi, D Schwarzer, W Plunkett, B Aronow, O Gozani, W Fischle, MC Hung, DJ Patel and MC Barton. 2010. Nature 468: 927-932.
Rewiring of genetic networks in response to DNA damage. Bandyopadhyay S, M Mehta, D Kuo, MK Sung, R Chuang, EJ Jaehnig, B Bodenmiller, K Licon, W Copeland, M Shales, D Fiedler, J Dutkowski, A Guenole, H van Attikum, KM Shokat, RD Kolodner, WK Huh, R Aebersold, MC Keogh, NJ Krogan and T Ideker. 2010. Science 330: 1385-1389.
Histone H2B ubiquitination and beyond: Regulation of nucleosome stability, chromatin dynamics and the trans-histone H3 methylation. Chandrasekharan MB, F Huang and ZW Sun. 2010. Epigenetics 5: 460-468.
The JmjN domain of Jhd2 is important for its protein stability, and the plant homeodomain (PHD) finger mediates its chromatin association independent of H3K4 methylation. Huang F, MB Chandrasekharan, YC Chen, S Bhaskara, SW Hiebert and ZW Sun. 2010. J Biol Chem 285: 24548-24561.
A functional link between the histone demethylase PHF8 and the transcription factor ZNF711 in X-linked mental retardation. Kleine-Kohlbrecher D, J Christensen, J Vandamme, I Abarrategui, M Bak, N Tommerup, X Shi, O Gozani, J Rappsilber, AE Salcini and K Helin. 2010. Mol Cell 38: 165-178.
Sometimes one just isn't enough: do vertebrates contain an H2A.Z hyper-variant?. Mehta M, HS Kim and MC Keogh. 2010. J Biol 9: 3.
The ubiquitin-conjugating enzyme HR6B is required for maintenance of X chromosome silencing in mouse spermatocytes and spermatids. Mulugeta Achame E, E Wassenaar, JW Hoogerbrugge, E Sleddens-Linkels, M Ooms, ZW Sun, IWF van, JA Grootegoed and WM Baarends. 2010. BMC Genomics 11: 367.
Ubiquitination of histone H2B regulates chromatin dynamics by enhancing nucleosome stability. Chandrasekharan MB, F Huang and ZW Sun. 2009. Proc Natl Acad Sci U S A 106: 16686-16691.
Crystal structure of the three tandem FF domains of the transcription elongation regulator CA150. Lu M, J Yang, Z Ren, S Sabui, A Espejo, MT Bedford, RH Jacobson, D Jeruzalmi, JS McMurray and X Chen. 2009. J Mol Biol 393: 397-408.
Functional organization of the S. cerevisiae phosphorylation network. Fiedler D, H Braberg, M Mehta, G Chechik, G Cagney, P Mukherjee, AC Silva, M Shales, SR Collins, S van Wageningen, P Kemmeren, FC Holstege, JS Weissman, MC Keogh, D Koller, KM Shokat and NJ Krogan. 2009. Cell 136: 952-963.
Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family. Herrmann F, P Pably, C Eckerich, MT Bedford and FO Fackelmayer. 2009. J Cell Sci 122: 667-677.
Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Chang Y, X Zhang, JR Horton, AK Upadhyay, A Spannhoff, J Liu, JP Snyder, MT Bedford and X Cheng. 2009. Nat Struct Mol Biol 16: 312-317.
ING4 mediates crosstalk between histone H3 K4 trimethylation and H3 acetylation to attenuate cellular transformation. Hung T, O Binda, KS Champagne, AJ Kuo, K Johnson, HY Chang, MD Simon, TG Kutateladze and O Gozani. 2009. Mol Cell 33: 248-256.
HBO1 HAT complexes target chromatin throughout gene coding regions via multiple PHD finger interactions with histone H3 tail. Saksouk N, N Avvakumov, KS Champagne, T Hung, Y Doyon, C Cayrou, E Paquet, M Ullah, AJ Landry, V Cote, XJ Yang, O Gozani, TG Kutateladze and J Cote. 2009. Mol Cell 33: 257-265.
Protein arginine methylation in mammals: who, what, and why. Bedford MT and SG Clarke. 2009. Mol Cell 33: 1-13.
Protein modifications in transcription elongation. Fuchs SM, RN Laribee and BD Strahl. 2009. Biochim Biophys Acta 1789: 26-36.
SIRT6 stabilizes DNA-dependent protein kinase at chromatin for DNA double-strand break repair. McCord RA, E Michishita, T Hong, E Berber, LD Boxer, R Kusumoto, S Guan, X Shi, O Gozani, AL Burlingame, VA Bohr and KF Chua. 2009. Aging (Albany NY) 1: 109-121.
EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells. Zagurovskaya M, MM Shareef, A Das, A Reeves, S Gupta, M Sudol, MT Bedford, J Prichard, M Mohiuddin and MM Ahmed. 2009. Oncogene 28: 1121-1131.
Ctk1 promotes dissociation of basal transcription factors from elongating RNA polymerase II. Ahn SH, MC Keogh and S Buratowski. 2009. EMBO J 28: 205-212.
The target of the NSD family of histone lysine methyltransferases depends on the nature of the substrate. Li Y, P Trojer, CF Xu, P Cheung, A Kuo, WJ Drury, 3rd, Q Qiao, TA Neubert, RM Xu, O Gozani and D Reinberg. 2009. J Biol Chem 284: 34283-34295.
An acetylated form of histone H2A.Z regulates chromosome architecture in Schizosaccharomyces pombe. Kim HS, V Vanoosthuyse, J Fillingham, A Roguev, S Watt, T Kislinger, A Treyer, LR Carpenter, CS Bennett, A Emili, JF Greenblatt, KG Hardwick, NJ Krogan, J Bahler and MC Keogh. 2009. Nat Struct Mol Biol 16: 1286-1293.
Cell cycle-dependent deacetylation of telomeric histone H3 lysine K56 by human SIRT6. Michishita E, RA McCord, LD Boxer, MF Barber, T Hong, O Gozani and KF Chua. 2009. Cell Cycle 8: 2664-2666.
Histone H2BK123 monoubiquitination is the critical determinant for H3K4 and H3K79 trimethylation by COMPASS and Dot1. Nakanishi S, JS Lee, KE Gardner, JM Gardner, YH Takahashi, MB Chandrasekharan, ZW Sun, MA Osley, BD Strahl, SL Jaspersen and A Shilatifard. 2009. J Cell Biol 186: 371-377.
Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. Xie Y, S Ke, N Ouyang, J He, W Xie, MT Bedford and Y Tian. 2009. J Biol Chem 284: 9199-9205.
Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Dacwag CS, MT Bedford, S Sif and AN Imbalzano. 2009. Mol Cell Biol 29: 1909-1921.
NMR assignments and histone specificity of the ING2 PHD finger. Pena PV, CA Musselman, AJ Kuo, O Gozani and TG Kutateladze. 2009. Magn Reson Chem 47: 352-358.
IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. Repass JF, MN Laurent, C Carter, B Reizis, MT Bedford, K Cardenas, P Narang, M Coles and ER Richie. 2009. Genesis 47: 281-287.
Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks. Bua DJ, AJ Kuo, P Cheung, CL Liu, V Migliori, A Espejo, F Casadio, C Bassi, B Amati, MT Bedford, E Guccione and O Gozani. 2009. PLoS One 4: e6789.
Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. Ito T, N Yadav, J Lee, T Furumatsu, S Yamashita, K Yoshida, N Taniguchi, M Hashimoto, M Tsuchiya, T Ozaki, M Lotz, MT Bedford and H Asahara. 2009. BMC Dev Biol 9: 47.
The Set2/Rpd3S pathway suppresses cryptic transcription without regard to gene length or transcription frequency. Lickwar CR, B Rao, AA Shabalin, AB Nobel, BD Strahl and JD Lieb. 2009. PLoS One 4: e4886.
Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. Ludes-Meyers JH, H Kil, J Parker-Thornburg, DF Kusewitt, MT Bedford and CM Aldaz. 2009. PLoS One 4: e7775.
Aire employs a histone-binding module to mediate immunological tolerance, linking chromatin regulation with organ-specific autoimmunity. Koh AS, AJ Kuo, SY Park, P Cheung, J Abramson, D Bua, D Carney, SE Shoelson, O Gozani, RE Kingston, C Benoist and D Mathis. 2008. Proc Natl Acad Sci U S A 105: 15878-15883.
Epigenomics: a roadmap to chromatin. Henikoff S, BD Strahl and PE Warburton. 2008. Science 322: 853.
Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. Hassa PO, M Covic, MT Bedford and MO Hottiger. 2008. J Mol Biol 377: 668-678.
SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Michishita E, RA McCord, E Berber, M Kioi, H Padilla-Nash, M Damian, P Cheung, R Kusumoto, TL Kawahara, JC Barrett, HY Chang, VA Bohr, T Ried, O Gozani and KF Chua. 2008. Nature 452: 492-496.
Histone H3K4me3 binding is required for the DNA repair and apoptotic activities of ING1 tumor suppressor. Pena PV, RA Hom, T Hung, H Lin, AJ Kuo, RP Wong, OM Subach, KS Champagne, R Zhao, VV Verkhusha, G Li, O Gozani and TG Kutateladze. 2008. J Mol Biol 380: 303-312.
Chaperone control of the activity and specificity of the histone H3 acetyltransferase Rtt109. Fillingham J, J Recht, AC Silva, B Suter, A Emili, I Stagljar, NJ Krogan, CD Allis, MC Keogh and JF Greenblatt. 2008. Mol Cell Biol 28: 4342-4353.
Arginine methylation of the histone H3 tail impedes effector binding. Iberg AN, A Espejo, D Cheng, D Kim, J Michaud-Levesque, S Richard and MT Bedford. 2008. J Biol Chem 283: 3006-3010.
CARM1 promotes adipocyte differentiation by coactivating PPARgamma. Yadav N, D Cheng, S Richard, M Morel, VR Iyer, CM Aldaz and MT Bedford. 2008. EMBO Rep 9: 193-198.
Role for 53BP1 Tudor domain recognition of p53 dimethylated at lysine 382 in DNA damage signaling. Kachirskaia I, X Shi, H Yamaguchi, K Tanoue, H Wen, EW Wang, E Appella and O Gozani. 2008. J Biol Chem 283: 34660-34666.
The histone methylase Set2p and the histone deacetylase Rpd3p repress meiotic recombination at the HIS4 meiotic recombination hotspot in Saccharomyces cerevisiae. Merker JD, M Dominska, PW Greenwell, E Rinella, DC Bouck, Y Shibata, BD Strahl, P Mieczkowski and TD Petes. 2008. DNA Repair (Amst) 7: 1298-1308.
A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Schotta G, R Sengupta, S Kubicek, S Malin, M Kauer, E Callen, A Celeste, M Pagani, S Opravil, IA De La Rosa-Velazquez, A Espejo, MT Bedford, A Nussenzweig, M Busslinger and T Jenuwein. 2008. Genes Dev 22: 2048-2061.
Roles for Ctk1 and Spt6 in regulating the different methylation states of histone H3 lysine 36. Youdell ML, KO Kizer, E Kisseleva-Romanova, SM Fuchs, E Duro, BD Strahl and J Mellor. 2008. Mol Cell Biol 28: 4915-4926.
Deletion of histone deacetylase 3 reveals critical roles in S phase progression and DNA damage control. Bhaskara S, BJ Chyla, JM Amann, SK Knutson, D Cortez, ZW Sun and SW Hiebert. 2008. Mol Cell 30: 61-72.
epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. Mai A, D Cheng, MT Bedford, S Valente, A Nebbioso, A Perrone, G Brosch, G Sbardella, F De Bellis, M Miceli and L Altucci. 2008. J Med Chem 51: 2279-2290.
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WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Bedford MT, R Reed and P Leder. 1998. Proc Natl Acad Sci U S A 95: 10602-10607.
Transcriptional activation of the ovine follicle-stimulating hormone beta-subunit gene by gonadotropin-releasing hormone: involvement of two activating protein-1-binding sites and protein kinase C. Strahl BD, HJ Huang, J Sebastian, BR Ghosh and WL Miller. 1998. Endocrinology 139: 4455-4465.
Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. Wang C, K Chua, W Seghezzi, E Lees, O Gozani and R Reed. 1998. Genes Dev 12: 1409-1414.
Essential and redundant functions of histone acetylation revealed by mutation of target lysines and loss of the Gcn5p acetyltransferase. Zhang W, JR Bone, DG Edmondson, BM Turner and SY Roth. 1998. EMBO J 17: 3155-3167.
SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex. Zhang Y, ZW Sun, R Iratni, H Erdjument-Bromage, P Tempst, M Hampsey and D Reinberg. 1998. Mol Cell 1: 1021-1031.
A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site. Gozani O, J Potashkin and R Reed. 1998. Mol Cell Biol 18: 4752-4760.
Cyclin E associates with components of the pre-mRNA splicing machinery in mammalian cells. Seghezzi W, K Chua, F Shanahan, O Gozani, R Reed and E Lees. 1998. Mol Cell Biol 18: 4526-4536.
In vivo functions of histone acetylation/deacetylation in Tup1p repression and Gcn5p activation. Edmondson DG, W Zhang, A Watson, W Xu, JR Bone, Y Yu, D Stillman and SY Roth. 1998. Cold Spring Harb Symp Quant Biol 63: 459-468.
FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. Bedford MT, DC Chan and P Leder. 1997. EMBO J 16: 2376-2383.
Two proximal activating protein-1-binding sites are sufficient to stimulate transcription of the ovine follicle-stimulating hormone-beta gene. Strahl BD, HJ Huang, NR Pedersen, JC Wu, BR Ghosh and WL Miller. 1997. Endocrinology 138: 2621-2631.
High efficiency reporter gene transfection of vascular tissue in vitro and in vivo using a cationic lipid-DNA complex. Keogh MC, D Chen, F Lupu, N Shaper, JF Schmitt, VV Kakkar and NR Lemoine. 1997. Gene Ther 4: 162-171.
A function for CD2 on murine B cells?. Keogh MC, J Elliot, T Norton and RA Lake. 1997. Immunol Cell Biol 75: 333-339.
Dosage compensation regulatory proteins and the evolution of sex chromosomes in Drosophila. Bone JR and MI Kuroda. 1996. Genetics 144: 705-713.
Inhibin and estradiol alter gonadotropes differentially in ovine pituitary cultures: changing gonadotrope numbers and calcium responses to gonadotropin-releasing hormone. Ghosh BR, JC Wu, BD Strahl, GV Childs and WL Miller. 1996. Endocrinology 137: 5144-5154.
Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. Chan DC, MT Bedford and P Leder. 1996. EMBO J 15: 1045-1054.
RNA-dependent association of the Drosophila maleless protein with the male X chromosome. Richter L, JR Bone and MI Kuroda. 1996. Genes Cells 1: 325-336.
Functional interaction between TFIIB and the Rpb9 (Ssu73) subunit of RNA polymerase II in Saccharomyces cerevisiae. Sun ZW, A Tessmer and M Hampsey. 1996. Nucleic Acids Res 24: 2560-2566.
Identification of proteins that interact with exon sequences, splice sites, and the branchpoint sequence during each stage of spliceosome assembly. Chiara MD, O Gozani, M Bennett, P Champion-Arnaud, L Palandjian and R Reed. 1996. Mol Cell Biol 16: 3317-3326.
Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A. Gozani O, R Feld and R Reed. 1996. Genes Dev 10: 233-243.
Synthetic enhancement of a TFIIB defect by a mutation in SSU72, an essential yeast gene encoding a novel protein that affects transcription start site selection in vivo. Sun ZW and M Hampsey. 1996. Mol Cell Biol 16: 1557-1566.
Ectopic expression of Fgf-4 in chimeric mouse embryos induces the expression of early markers of limb development in the lateral ridge. Abud HE, JA Skinner, FJ McDonald, MT Bedford, P Lonai and JK Heath. 1996. Dev Genet 19: 51-65.
Accumulation of a novel spliceosomal complex on pre-mRNAs containing branch site mutations. Champion-Arnaud P, O Gozani, L Palandjian and R Reed. 1995. Mol Cell Biol 15: 5750-5756.
SSU71, encoding the largest subunit of TFIIF, is located on the right arm of chromosome VII in Saccharomyces cerevisiae. Sun ZW and M Hampsey. 1995. Yeast 11: 789-791.
Identification of the gene (SSU71/TFG1) encoding the largest subunit of transcription factor TFIIF as a suppressor of a TFIIB mutation in Saccharomyces cerevisiae. Sun ZW and M Hampsey. 1995. Proc Natl Acad Sci U S A 92: 3127-3131.
A novel set of spliceosome-associated proteins and the essential splicing factor PSF bind stably to pre-mRNA prior to catalytic step II of the splicing reaction. Gozani O, JG Patton and R Reed. 1994. EMBO J 13: 3356-3367.
Acetylated histone H4 on the male X chromosome is associated with dosage compensation in Drosophila. Bone JR, J Lavender, R Richman, MJ Palmer, BM Turner and MI Kuroda. 1994. Genes Dev 8: 96-104.
Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Orr-Urtreger A, MT Bedford, T Burakova, E Arman, Y Zimmer, A Yayon, D Givol and P Lonai. 1993. Dev Biol 158: 475-486.
SpCOUP-TF: a sea urchin member of the steroid/thyroid hormone receptor family. Chan SM, N Xu, CC Niemeyer, JR Bone and CN Flytzanis. 1992. Proc Natl Acad Sci U S A 89: 10568-10572.
Developmental expression of the alpha receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation. Orr-Urtreger A, MT Bedford, MS Do, L Eisenbach and P Lonai. 1992. Development 115: 289-303.
Analysis of allele-specific methylation. Bedford MT and PD van Helden. 1990. Trends Genet 6: 140-141.
A method to analyze allele-specific methylation. Bedford MT and PD van Helden. 1990. Biotechniques 9: 744-748.
Hypomethylation of DNA in pathological conditions of the human prostate. Bedford MT and PD van Helden. 1987. Cancer Res 47: 5274-5276.