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EpiCypher

Product References

References Citing Specific EpiCypher Products

Nucleosomes

Biotinylated 601 DNA - Catalog No. 18-0001

  • Lowary PT and J Widom (1998). New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning. J Mol Biol 276: 19-42. Link

Chicken Nucleosomes - Catalog No. 16-0004

  • Adhvaryu KK et al (2005). Methylation of histone H3 lysine 36 is required for normal development in Neurospora crassa. Eukaryot Cell 4: 1455-1564. Link
  • Kizer KO et al (2005). A novel domain in Set2 mediates RNA polymerase II interaction and couples histone H3 K36 methylation with transcript elongation. Mol Cell Biol 25: 3305-3316. Link
  • Morris SA et al (2005). Histone H3 K36 methylation is associated with transcription elongation in Schizosaccharomyces pombe. Eukaryot Cell 4: 1446-1454. Link

HeLa Nucleosomes - Catalog Nos. 16-0002 and 16-0003

  • Sisirak V et al (2016). Digestion of Chromatin in Apoptotic Cell Microparticles Prevents Autoimmunity. Cell 166: 88-101. Link
  • Laurent B and Y Shi. (2016). Expression, Purification, and Biochemical Analysis of the LSD1/KDM1A Histone Demethylase. Meth Enzymol 573: 241-259. Link
  • Masuda Y et al (2015). TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nature Comm 442: 7299. Link
  • Kuo AJ et al (2011). NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell 44: 609-620. Link
  • Matthews AG et al (2007). RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination. Nature 450: 1106-1110. Link
  • Shi X et al (2006). ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature 442: 96-99. Link

Recombinant NucleosomesLink

  • Strelow JM et al (2016). The Use of Nucleosome Substrates Improves Binding of SAM Analogs to SETD8. J Biomol Screen 21: 786-794. Link
  • Munari F et al (2012). Methylation of lysine 9 in histone H3 directs alternative modes of highly dynamic interaction of heterochromatin protein hHP1β with the nucleosome. J Biol Chem 287: 33756-33765. Link
  • Luger K et al (1999). Expression and purification of recombinant histones and nucleosome reconstitution. Methods Mol Biol 119: 1-16. Link
  • Lowary PT and J Widom (1998). New DNA sequence rules for high affinity binding to histone octamer and sequence-directed nucleosome positioning. J Mol Biol 276: 19-42. Link

Recombinant Octamers - Catalog No. 16-0001

  • Masuda Y et al (2015). TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin. Nature Comm 442: 7299. Link
  • Cao XJ et al (2013). Large-scale global identification of protein lysine methylation in vivo. Epigenetics 8: 477 - 485. Link

Biotinylated Histone Peptides - Link

  • Li S et al (2016). Mouse MORC3 is a GHKL ATPase that localizes to H3K4me3 marked chromatin. PNAS USA Link
  • Zhang CJ et al (2016). The Arabidopsis acetylated histone-binding protein BRAT1 forms a complex with BRP1 and prevents transcriptional silencing. Nat Commun 7: 11715. doi: 10.1038/ncomms11715 Link
  • Khan DH et al (2016). Dynamic Histone Acetylation of H3K4me3 Nucleosome Regulates MCL1 Pre-mRNA Splicing. J Cell Physiol. doi: 10.1002/jcp.25337 Link
  • Hattori T, Taft JM, Swist KM, Luo H, Witt H, Slattery M, Koide A, Ruthenburg AJ, Krajewski K, Strahl BD, White KP, Farnham PJ, Zhao Y, Koide S (2013). Recombinant antibodies to histone post-translational modifications. Nat Methods 10: 992-995. Link
  • Fuchs SM, Krajewski K, Baker RW, Miller VL, Strahl BD (2011). Influence of combinatorial histone modifications on antibody and effector protein recognition. Curr Biol 21: 53-58. Link

 

Histone Peptide Arrays - Catalog Nos. 11-1001 and 11-1002

  • Fuchs SM, Krajewski K, Baker RW, Miller VL, Strahl BD (2011). Influence of combinatorial histone modifications on antibody and effector protein recognition. Curr Biol 21: 53-58. Link
  • Rothbart SB, Krajewski K, Strahl BD, Fuchs, SM (2012). Peptide microarrays to interrogate the histone code. Methods Enzymol 512: 107-135. Link
  • Rothbart SB et al (2012). Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol 19: 1155-1160. Link
  • Cai L et al (2013). An H3K36 Methylation-Engaging Tudor Motif of Polycomb-like Proteins Mediates PRC2 Complex Targeting. Mol Cell 49: 571-582. Link
  • Gatchalian J et al (2013). Dido3 PHD modulates cell differentiation and division. Cell Rep 4: 148-158. Link
  • Rothbart SB et al (2013). Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation. Genes Dev 27: 1288-1298. Link
  • Ali M et al (2013). Molecular basis for chromatin binding and regulation of MLL5. PNAS USA 110: 11296-11301. Link
  • Kinkelin K et al (2013). Structures of RNA polymerase II complexes with Bye1, a chromatin-binding PHF3/DIDO homologue. PNAS USA 110: 15277-15282. Link
  • Klein BJ et al (2014). The histone-H3K4-specific demethylase KDM5B binds to its substrate and product through distinct PHD fingers. Cell Rep 6: 325-335. Link
  • Kim HS et al (2014). Identification of a BET family bromodomain/casein kinase II/TAF-containing complex as a regulator of mitotic condensin function. Cell Rep 6: 892-905. Link
  • Greer EL et al (2014). A histone methylation network regulates transgenerational epigenetic memory in C. elegans. Cell Rep 7: 113-126. Link
  • Dickson BM et al (2016). ArrayNinja: An Open Source Platform for Unified Planning and Analysis of Microarray Experiments. Meth Enzymol. doi: 10.1016/bs.mie.2016.02.002. Link


Antibodies

Asymmetric Dimethyl-arginine Antibody (ADMA) Asym25b - Catalog No. 13-0010

  • Boisvert FM et al (2003). A proteomic analysis of arginine-methylated protein complexes.Mol Cell Proteom 2: 1319-1330. Link
  • Yu Z et al (2009). A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol Cell Biol 29: 2982-2996. Link
  • Yu Z et al (2012). The MRE11 GAR motif regulates DNA double-strand break processing and ATR activation.Cell Res 22: 305-320. Link
  • Tradewell ML et al (2012). Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations. Hum Mol Genet 21: 136-149. Link
CARM1 / PRMT4 - Catalog No. 13-0006
  • Kim J et al (2004) J Biol Chem 279: 25339-25344. Link
  • Yu Z et al (2009). A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol Cell Biol 29: 2982-2996. Link
GST Epitope Tag Antibody - Catalog No. 13-0022
  • Hacker KEet al (2016). Structure/Function Analysis of Recurrent Mutations in SETD2 Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and H3K36 Trimethylation. J Biol Chem Link

Histone H3 C-terminal Antibody - Catalog No. 13-0001

  • Hacker KEet al (2016). Structure/Function Analysis of Recurrent Mutations in SETD2 Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and H3K36 Trimethylation. J Biol Chem Link
  • Jha DK and Strahl BD (2014). An RNA polymerase II-coupled function for histone H3K36 methylation in checkpoint activation and DSB repair. Nat Commun 5: 3965. Link
  • Rothbart SB et al (2013). Multivalent histone engagement by the linked tandem Tudor and PHD domains of UHRF1 is required for the epigenetic inheritance of DNA methylation. Genes Dev 27: 1288-1298. Link
  • Rizzardi LF et al (2012). DNA replication origin function is promoted by H3K4 di-methylation in Saccharomyces cerevisiae. Genetics 192: 371-384. Link
  • Rothbart SB et al (2012). Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol 11: 1155-1160. Link

H3 K4 Me3 - Catalog No. 13-0004

  • Hacker KEet al (2016). Structure/Function Analysis of Recurrent Mutations in SETD2 Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and H3K36 Trimethylation. J Biol Chem Link
  • Seward DJ et al (2007). Demethylation of trimethylated histone H3 Lys4 in vivo by JARID1 JmjC proteins. Nat Struct Mol Biol 14: 240-242. Link
  • Zhang L et al (2005). Altered nucleosome occupancy and histone H3K4 methylation in response to 'transcriptional stress'. EMBO J 24: 2379-2390. Link
NSD2 - Catalog No. 13-0002
  • Kuo AJ et al (2011). NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell 44: 609-620. Link
PRMT1 - Catalog No. 13-0007
  • Côte J et al (2003). Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell 14: 274-287. Link
  • Yu Z et al (2009). A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol Cell Biol 29: 2982-2996. Link
  • Tradewell ML et al (2012). Arginine methylation by PRMT1 regulates nuclear-cytoplasmic localization and toxicity of FUS/TLS harbouring ALS-linked mutations. Hum Mol Genet 21: 136-149. Link
  • Dhar S et al (2013). Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Sci Rep 3: 1311. Link

PRMT5 / JBP1 - Catalog No. 13-0008

  • Boisvert FM et al (2002). Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing. J Cell Biol 159: 957-969. Link
  • Gonsalvez GB et al (2007). Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. J Cell Biol 178: 733-740. Link
  • Yu Z et al (2009). A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol Cell Biol 29: 2982-2996. Link

PRMT7 - Catalog No. 13-0009

  • Gonsalvez GB et al (2007). Two distinct arginine methyltransferases are required for biogenesis of Sm-class ribonucleoproteins. J Cell Biol 178: 733-740. Link
  • Yu Z et al (2009). A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol Cell Biol 29: 2982-2996. Link

SETD6 - Catalog No. 13-0003

  • Levy D et al (2011). Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol 12: 29-36. Link
Symmetric Dimethyl-arginine Antibody (SDMA) Sym10 - Catalog No. 13-0012
  • Boisvert FM et al (2002). Symmetrical dimethylarginine methylation is required for the localization of SMN in Cajal bodies and pre-mRNA splicing. J Cell Biol 159: 957-969. Link
  • Boisvert FM et al (2003). A proteomic analysis of arginine-methylated protein complexes.Mol Cell Proteom 2: 1319-1330. Link
  • Côte J et al (2005). Tudor domains bind symmetrical dimethylated arginines. J Biol Chem 280: 28476-28483. Link
  • Deng X et al (2010). Arginine methylation mediated by the Arabidopsis homolog of PRMT5 is essential for proper pre-mRNA splicing. PNAS USA 107: 19114–19119. Link
  • Jung GA et al (2011). Methylation of eukaryotic elongation factor 2 induced by basic fibroblast growth factor via mitogen-activated protein kinase. Exp Mol Med 43:550-560. Link

 

Enzymes and Recombinant Proteins

CENP-A / H4 Tetramers - Catalog No. 16-0010
  • Sekulic N et al (2010). The structure of (CENP-A-H4)2 reveals physical features that mark centromeres. Nature 476: 347-351. Link
  • Falk SJ et al (2015). CENP-C reshapes and stabilizes CENP-A nucleosomes at the centromere. Science 348: 699-703. Link
DOT1L - Catalog No. 15-1001
  • Kuo AJ et al (2011). NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell 44: 609-620. Link
G9a - Catalog No. 15-1008
  • Kuo AJ et al (2011). NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell 44: 609-620. Link
L3MBTL1 3xMBT Domain - Catalog No. 15-0043
  • Moore KE et al (2013). A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. Mol Cell 50: 444-456. Link
SETD2 - Catalog No. 15-1011
  • Hacker KEet al (2016). Structure/Function Analysis of Recurrent Mutations in SETD2 Reveals a Critical and Conserved Role for a SET Domain Residue in Maintaining Protein Stability and H3K36 Trimethylation. J Biol Chem Link
SETD6 - Catalog No. 15-1004
  • Levy D et al (2011). Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol 12: 29-36. Link
SMYD3 - Catalog No. 15-1007
  • Van Aller GS et al (2012). Smyd3 regulates cancer cell phenotypes and catalyzes histone H4 lysine 5 methylation. Epigenetics 7: 340-343. Link
  Histone Expression Vectors - Catalog Nos. 18-0002 to 18-0004
  • Lewis PW et al (2013). Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 340: 857-861. Link