Modified Designer Nucleosomes (dNucs™)

EpiCypher dNucs™ are semi-synthetic recombinant nucleosomes, containing one (or more) histone PTMs. Nucleosomes are the natural target of chromatin readers and modifying enzymes, and thus provide a superior substrate for epigenetic enzymes and interactor proteins.

Shop dNucs dNuc Smaller Pack Sizes

dNuc substrates enable cutting-edge chromatin research

EpiCypher has an extensive library of >70 uniquely modified dNucs, useful for:

dCypher™: Discovery platform to study chromatin readers and enzymes
AlphaNuc™: HTS assays for inhibitor development
EpiDyne®: Quantitative chromatin remodeling assays
Interested? Use the promo code "4for3" to buy any 3 full size dNucs and get one free!

Learn more:

Recombinant Nucleosomes Brochure
Using dNucs to study chromatin readers or PTM binding specificity? See our dCypher Tech Note!
Interested in inhibitor screening? See our Tech Note AlphaNuc HTS assays
How do we quantify our nucleosomes? See our Nucleosome Quantification Method

Shop related products and services:

Nucleosome, Recombinant Human, H3K4,K27me3 dNuc, Biotinylated

SKU: 16-0403

Description Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P20671;...

$575.00

Nucleosome, Recombinant Human, H3K4,K9me3 dNuc, Biotinylated

SKU: 16-0402

Species: Human Source: E. coli & synthetic DNA Tag: Biotinylated ...

$575.00

Nucleosome, Recombinant Human, H3K18ub1 dNuc, Biotinylated

SKU: 16-0401

Description Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P20671;...

$525.00

Nucleosome, Recombinant Human, H2AK129ub1 dNuc, Biotinylated

SKU: 16-0400

Description Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P20671;...

$525.00

Nucleosome, Recombinant Human, H2AK15ub1 dNuc, Biotinylated

SKU: 16-0399

Description Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P20671;...

$525.00

Nucleosome, Recombinant Human, H3K14ub1 dNuc, Biotinylated

SKU: 16-0398

Species: Human Source: E. coli & synthetic DNA Tag: Biotinylated Molecular Weight: 216,857.3 Da ...

$525.00

Nucleosome, Recombinant Human, H3.1K27me3,S28phos, Biotinylated

SKU: 16-0397

Description Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P04908;...

$575.00

Nucleosome, Recombinant Human, H2AK119ub1 dNuc, Biotinylated

SKU: 16-0395

Nucleosome, Recombinant Human, H2AK119ub dNuc, Biotinylated Description: Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P04908; H2B-O60814; H3.1-P68431;...

$525.00

Nucleosome, Recombinant Human, H2BK120ub1 dNuc, Biotinylated

SKU: 16-0396

Nucleosome, Recombinant Human, H2BK120ub dNuc, Biotinylated Description: Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P04908; H2B-O60814; H3.1-P68431;...

$525.00

Nucleosome, Recombinant Human, H3K4me3 dNuc, Non‑biotinylated

SKU: 16-1316

Description Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P04908;...

$575.00

Nucleosome, Recombinant Human, H4K12me1 dNuc, Biotinylated

SKU: 16-0393

Nucleosome, Recombinant Human, H4K12me1 dNuc, Biotinylated Description: Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P04908; H2BO60814; H3.1-P68431;...

$575.00

Nucleosome, Recombinant Human, H3.3K36me3 dNuc, Biotinylated

SKU: 16-0390

Species: Human Source: E. coli & synthetic DNA Tag: Biotinylated Molecular Weight: 199,749.4 Da ...

$575.00

Nucleosome, Recombinant Human, H3.3S31phos dNuc, Biotinylated

SKU: 16-0389

Species: Human Source: E. coli & synthetic DNA Tag: Biotinylated Molecular Weight: 199,867 Da Description ...

$575.00

Nucleosome, Recombinant Human, H3.1S28phos dNuc, Biotinylated

SKU: 16-0388

Nucleosome, Recombinant Human, H3.1S28phos dNuc, Biotinylated Description: Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P04908; H2B-O60814; H3.1-P68431;...

$575.00

Nucleosome, Recombinant Human, H2BK20ac dNuc, Biotinylated

SKU: 16-0387

Nucleosome, Recombinant Human, H2BK20ac dNuc, Biotinylated Description: Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P04908; H2B-O60814; H3.1-P68431;...

$575.00

Nucleosome, Recombinant Human, H2BK12ac dNuc, Biotinylated

SKU: 16-0386

Nucleosome, Recombinant Human, H2BK12ac dNuc, Biotinylated Description: Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P04908; H2B-O60814; H3.1-P68431;...

$575.00

Nucleosome, Recombinant Human, H3K27acS28phos dNuc, Biotinylated

SKU: 16-0385

Species: Human Source: E. coli & synthetic DNA Tag: Biotinylated MW: 200,103.26 Da Description ...

$575.00

Nucleosome, Recombinant Human, H3K27bu dNuc, Biotinylated

SKU: 16-0384

Nucleosome, Recombinant Human, H3K27bu dNuc, Biotinylated Description: Mononucleosomes assembled from recombinant human histones expressed in E. coli (two each of histones H2A, H2B, H3 and H4; accession numbers: H2A-P04908; H2BO60814; H3.1-P68431;...

$575.00

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